CD74 antibody (HLA-DR-gamma) (AA 1-106)

Details for Product anti-CD74 Antibody No. ABIN1724870
Antigen
Epitope
AA 1-106
42
20
16
15
6
5
4
4
4
3
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
455
98
31
22
Host
Mouse
383
103
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CD74 antibody is un-conjugated
32
30
18
14
12
9
7
7
7
7
7
7
7
7
7
7
7
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), ELISA, Western Blotting (WB)
286
284
207
100
77
60
55
48
46
40
14
13
10
2
2
2
2
2
1
1
Options
Immunogen Purified recombinant fragment of human CD74 (AA 1-106) expressed in E. Coli.
Clone 2D1B11
Isotype IgG1
Purification Purified
Antigen
Alternative Name CD74 (CD74 Antibody Abstract)
Background The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. ,
Molecular Weight 33.5 kDa
Gene ID 972
HGNC 972
Pathways Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-HLA-DR-gamma (CD74) (AA 1-106) antibody (ABIN1724870) anti-HLA-DR-gamma (CD74) (AA 1-106) antibody (Image 1)
Image no. 2 for anti-HLA-DR-gamma (CD74) (AA 1-106) antibody (ABIN1724870) anti-HLA-DR-gamma (CD74) (AA 1-106) antibody (Image 2)
Image no. 3 for anti-HLA-DR-gamma (CD74) (AA 1-106) antibody (ABIN1724870) anti-HLA-DR-gamma (CD74) (AA 1-106) antibody (Image 3)
Image no. 4 for anti-HLA-DR-gamma (CD74) (AA 1-106) antibody (ABIN1724870) anti-HLA-DR-gamma (CD74) (AA 1-106) antibody (Image 4)
Image no. 5 for anti-HLA-DR-gamma (CD74) (AA 1-106) antibody (ABIN1724870) anti-HLA-DR-gamma (CD74) (AA 1-106) antibody (Image 5)
Product cited in: Tian, Zhang, Li, Liu, Dong: "CD74: a potential novel target for triple-negative breast cancer." in: Tumour biology, Vol. 33, Issue 6, pp. 2273-7, 2012 (PubMed).

Zheng, Yang, Rong, Yuan, Ma, Wang, Shen, Cui: "CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer." in: World journal of gastroenterology : WJG, Vol. 18, Issue 18, pp. 2253-61, 2012 (PubMed).