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Psychological stress-derived CRF can breach the established endotoxin tolerance in the intestinal mucosa.
CRF plays a marked anxiogenic role at CRF1 receptors in the amygdala of mice exposed to the Elevated plus maze.
GABAA (show GABRg1 Proteins) receptor (GABAAR (show GABRG2 Proteins)) and the Na(+)-K(+)-2Cl(-) cotransporter (show SLC12A1 Proteins) (NKCC1 (show SLC12A2 Proteins)), but not the K(+)-Cl(-) cotransporter (show SLC12A4 Proteins) (KCC2 (show SLC12A5 Proteins)), were expressed in the terminals of the CRH neurons at the median eminence (ME). In contrast, CRH neuronal somata were enriched with KCC2 (show SLC12A5 Proteins) but not with NKCC1 (show SLC12A2 Proteins).
Excitability of genetically isolated CRF-receptive (CRFR1 (show CRHR1 Proteins)) neurons in the central nucleus of the amygdala (CeA (show CEA Proteins)) is potently enhanced by CRF and that CRFR1 (show CRHR1 Proteins) signaling in the CeA (show CEA Proteins) is critical for discriminative fear
activation of the Gq-membrane-associated estrogen receptors rapidly stimulates hypothalamic paraventricular nucleus CRH neurons by suppressing the M-current and potentiating glutamatergic neurotransmission
Data describe a missing function of the stress hormone Crh in the regulation of autophagy activation and present evidence that this effect is linked to maintenance of gut (show GUSB Proteins) homeostasis under basal conditions.
Real-time PCR analyses revealed that social defeat significantly increased corticotropin-releasing hormone in the paraventricular nucleus.
Data suggest a physiologically relevant role for local corticotropin-releasing hormone signaling towards shaping the neuronal circuitry within the mouse olfactory bulb.
results suggest that long-term, post-natal CRF over-expression increases the rewarding effects of cocaine in individuals with high emotional response to stress.
Knockdown of CRF synthesis in the ventral tegmental area prevented interpeduncular intermediate activation and anxiety during nicotine withdrawal.
Corticotrophin-releasing hormone accelerated tumor angiogenesis by upregulating VEGF expression and secretion in colon cancer cells.
This study found that the expressions of CRH and CRHR1 (show CRHR1 Proteins) were significantly higher in the epileptogenic tissues of patients with IS than in the control group.
The authors propose that conditions impacting on epiallele distribution influence the number of transcriptionally active CRH gene copies in the trophoblast cell population determining the gestational trajectory of placental CRH production in normal and pathological pregnancies.
Neuroimmune-endocrine events may lead to overactivity of sympathetic nervous system that triggers cascade of pathologic conditions in ovary in polycystic ovary syndrome (PCOS). Data suggest that women with PCOS exhibit reduction of CRH and NGF; reduction of CRH and NGF may be under influence of sympathetic nervous system and may reflect deficit of neuronal stress-adaptation in PCOS patients. (NGF = nerve growth factor)
brain activation in response to colorectal distention is enhanced after CRH injection in Irritable bowel syndrome patients compared to healthy controls
In deep infiltrating endometriotic lesions, CRH, Ucn and CRH-R2 (show CRHR2 Proteins) mRNA levels were significantly higher than in ovarian endometrioma.
In summary, cardiac expression of CRFR1, CRF, and Ucn3 genes is elevated in heart failure and may contribute to the activation of the CRF/Ucn system in these patients.
VIP (show Vip Proteins) and CRF reduce ADAMTS (show ADAMTS13 Proteins) expression and function in osteoarthritis synovial fibroblasts.
This study localized a complete CRF system in the human fetal heart.
Placenta CRH mRNA concentration appears to convey information about the risk of brain damage in the infant born at an extremely low gestational age.
Evidence is provided for porcine corticotropin releasing hormone (CRH) as a quantitative trait locus (QTL) affecting growth and body composition. (corticotropin releasing hormone; CRH; CRF)
CRH inhibits local progesterone production from luteal cells in swine corpus lutem.
We show that the CRF system is expressed in fish heart, is upregulated by hypoxia, and is cytoprotective.
Rigorous acute stressor stimuli induce behavioral changes, accompanied by an increase of cortisol levels with delayed control of CRH mRNA expression.
CRF localized in the preoptic area, periventricular hypothalamic and tectal regions, and dorsal part of the trigeminal motor nucleus.
The results of this study indicated that chronic CRF overexpression in primates not only increases Anxious Temperament but also affects metabolism and connectivity within components of Anxious Temperament 's neural circuitry.
We show that -2232C>G alters DNA x protein interactions and confers decreased sensitivity of the CRH promoter to glucocorticoids in vitro.
Data suggest that CRH promoter variation that confers increased stress reactivity increases the risk for alcohol use disorders in stress-exposed individuals.
The association has been reported between polymorphisms of the CRH and POMC (show POMC Proteins) genes with economic traits in Korean cattle.
CRH is a promising candidate gene for a concordant QTL related to lipid metabolism in mammals.
corticotropin-releasing factor mRNA fluctuated with food intake in the hypothalamus, pretectum, and optic tectum; CRF mRNA decreased 6 h after a meal and remained low through 31 days of food deprivation
Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.
, corticotropin releasing factor
, corticotropin-releasing factor
, corticotropin-releasing hormone
, corticotropin releasing hormone
, corticotrophin-releasing factor
, corticotropin releasing hormone, gene 1
, corticotropin-releasing factor b
, corticotropin releasing hormone b
, Corticotropin-releasing hormone
, corticotropin releasing hormone a
, corticotropin-releasing factor a
, C1q and tumor necrosis factor-related protein 14
, C1q related factor
, C1q-related factor
, C1q/TNF-related protein 14