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anti-Human FFAR1 Antibodies:
anti-Mouse (Murine) FFAR1 Antibodies:
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Human Polyclonal FFAR1 Primary Antibody for EIA, WB - ABIN952302
Lu, Jiang, Lv, Wu, Yu, Zhu: Molecular docking and molecular dynamics simulation studies of GPR40 receptor-agonist interactions. in Journal of molecular graphics & modelling 2010
Show all 5 references for ABIN952302
Human Polyclonal FFAR1 Primary Antibody for WB - ABIN656336
Nagasumi, Esaki, Iwachidow, Yasuhara, Ogi, Tanaka, Nakata, Yano, Shimakawa, Taketomi, Takeuchi, Odaka, Kaisho: Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice. in Diabetes 2009
Human Polyclonal FFAR1 Primary Antibody for ELISA, WB - ABIN185404
Hardy, St-Onge, Joly, Langelier, Prentki: Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40. in The Journal of biological chemistry 2005
Dog (Canine) Polyclonal FFAR1 Primary Antibody for WB - ABIN2792205
Sum, Tikhonova, Neumann, Engel, Raaka, Costanzi, Gershengorn: Identification of residues important for agonist recognition and activation in GPR40. in The Journal of biological chemistry 2007
It regulates insulin (show INS Antibodies) secretion in pancreatic beta-cells. (review)
Data from molecular docking simulations suggest that the binding pocket of GPR40 exhibits binding of free fatty acids (FFA) with chain lengths of C15 or fewer; for FFA with lengths longer than C15, part of alkyl chain extends out of binding pocket.
GPR120 (show O3FAR1 Antibodies) negatively and GPR40 positively regulate cellular functions during tumor progression in lung cancer cells.
Increased membrane permeability induced by linoleic acid is mediated by an intracellular signaling pathway activated by GPR40 that leads to an increase in membrane levels of Cx43 (show GJA1 Antibodies) phosphorylated at serine 373 via Akt (show AKT1 Antibodies).
These data demonstrate that R104 in GPR40 is critically involved in the normal receptor functions. Interestingly, R104P is a registered single-nucleotide polymorphism of GPR40.
Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120 (show O3FAR1 Antibodies)/FFA4
results suggest that FFAR1 is the functionally dominant free fatty acid receptor in both human and guinea pig airway smooth muscle.
upregulation of GPR40 expression enhances the mitogenic response to epoxyeicosatrienoic acids
Palmitic acid boosted inflammatory response of microvascular endothelial cells to LPS (show IRF6 Antibodies) via GPR40 and nSMase (show SMPD2 Antibodies).
knocking down the expression of the regulatory subunit PKAR1alpha, thereby reproducing the effects of IL-1beta (show IL1B Antibodies) and PGE (show LIPF Antibodies) on VSMCs, we demonstrated the contribution of PKA activity to the observed behavior of VSMCs
Data revealed a weak influence of GPR40 agonist on osteoblast markers expression. Nevertheless, a significant increase in OPG (show TNFSF11 Antibodies) expression was observed upon GW9508 treatment that contribute to explain the GPR40-related osteoporosis prevention
In the retinas of Vldlr (show VLDLR Antibodies)(-/-) mice with low fatty acid uptake but high circulating lipid levels, we found that Ffar1 suppresses expression of the glucose transporter Glut1 (show SLC2A1 Antibodies)
activation of the hypothalamic GPR40/FFA1 signaling pathway may regulate beta-endorphin (show POMC Antibodies) release via PC2 (show CBX4 Antibodies), and regulate the endogenous pain control system
These results suggest that both PPARgamma (show PPARG Antibodies) and GRP40 are required for RSG-induced inhibition of mouse calvaria osteoblast differentiation, which is mediated through GSK3beta (show GSK3b Antibodies)-dependent pathway.
GPR40 signaling pathway plays an important suppressive role in spinal nociceptive processing after inflammation or nerve injury
GPR 40/120 double-knockout mice are impaired in post-oral fat sensing.
GPR40/FFAR1 indirectly modulates organ-specific effects of CLAs.
GPR40 functions via both G protein-mediated and beta-arrestin-mediated mechanisms; endogenous and synthetic ligands differentially engage these pathways to promote insulin (show INS Antibodies) secretion.
results demonstrate that GPR40 deficiency leads to an extended osteoarthritis phenotype
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes.
free fatty acid receptor 1
, G protein-coupled receptor 40
, G-protein coupled receptor 40
, G protein-coupled receptor GPR40