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anti-Human GLP1R Antibodies:
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Human Polyclonal GLP1R Primary Antibody for DB, ICC - ABIN4314326
Kedees, Guz, Grigoryan, Teitelman: Functional activity of murine intestinal mucosal cells is regulated by the glucagon-like peptide-1 receptor. in Peptides 2013
Show all 6 Pubmed References
Human Polyclonal GLP1R Primary Antibody for IHC, IHC (p) - ABIN270557
Matveyenko, Dry, Cox, Moshtaghian, Gurlo, Galasso, Butler, Butler: Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin. in Diabetes 2009
Show all 2 Pubmed References
Human Polyclonal GLP1R Primary Antibody for IF (p), IHC (p) - ABIN731333
Zhou, Yang, Xin, Li, Guo, Hu, Zhou, Zhang, Zhang, Han, Chen: Exendin-4 protects adipose-derived mesenchymal stem cells from apoptosis induced by hydrogen peroxide through the PI3K/Akt-Sfrp2 pathways. in Free radical biology & medicine 2014
Show all 2 Pubmed References
Human Monoclonal GLP1R Primary Antibody for CyTOF, FACS - ABIN4899829
Thompson, Stephens, Bain, Kanamarlapudi: Molecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor Internalisation. in PLoS ONE 2016
Role of cysteine 341 and arginine 348 of GLP-1 receptor in G-protein coupling.
cryo-electron microscopy structure of the peptide-activated GLP-1R-Gs complex at near atomic resolution
Data show that exendin-4 (Ex-4) could attenuate breast cancer cell proliferation via activation of glucagonlike peptide-1 (GLP-1) receptor (GLP-1R) and subsequent inhibition of nuclear factor kappaB (NF-kappaB (show NFKB1 Antibodies) ) activation.
we saw that GLP-1 (show GCG Antibodies) induces phosphorylation of the epidermal growth factor receptor (show EGFR Antibodies) and activation of Foxo1 (show FOXO1 Antibodies), resulting in cell growth with concomitant enzyme release. Our work uncovers GLP-1 (show GCG Antibodies)-induced signaling pathways in the exocrine pancreas and suggests that increases in amylase (show AMY Antibodies) and lipase (show LIPG Antibodies) levels in subjects treated with GLP-1 receptor agonists reflect adaptive growth rather than early-stage pancreatitis.
crystal structure of the full-length GLP-1 receptor bound to a truncated peptide agonist
crystal structures of the human GLP-1R transmembrane domain in complex with two different negative allosteric modulators, PF-06372222 and NNC0640, at 2.7 and 3.0 A resolution, respectively
Data suggest that pancreatic level of GLP1R is highest in insulin (show INS Antibodies)-secreting cells; here, highest intensity of GLP1R immunostaining was observed in beta-cells in pancreatic tissues obtained from organ-donor cadavers with type 2 diabetes.
Data show that purified glucagon-like peptide-1 (GLP-1 (show GCG Antibodies)) receptor (GLP1R)GLP1R in nanodiscs that could bind to GLP-1 (show GCG Antibodies) and exendin-4 and activate Gs protein.
Dapagliflozin, when added in real life to patients with T2DM treated with GLP1-R agonists, induced a further significant, albeit modest improvement in A1C and a further weight loss.
analysis of the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor
GLP1-R may represent a novel target for treating bronchial hyperresponsiveness.
Our studies show that GLP-1R is widely expressed throughout the human hypothalamus. The decreased expression of GLP-1R in the PVN and IFN of T2DM patients may be related to the dysregulation of feeding behavior and glucose homeostasis in type 2 diabetes mellitus.
findings identify a group of proteins that interact with GLP-1R and show that one specific interacting protein, SERP1, has an important role in facilitating the glycosylation of GLP-1R and rescuing its activities after ER stress induced by tunicamycin.
Suggest transcription factor 7-like 2 (show TCF7L2 Antibodies) is a possible regulator of glucagon-like peptide 1 receptor expression in endothelial/smooth muscle cells in diabetic mice.
ventromedial hypothalamus GLP-1R regulates food intake by engaging key nutrient sensors but is dispensable for the effects of GLP (show GOLGA6A Antibodies)-1RA on nutrient homeostasis
GLP-1R is highly expressed within the lateral septum.
Study showe that GLP (show GOLGA6A Antibodies)-producing fibers interact with hypothalamic arcuate nucleus (ARC (show NOL3 Antibodies)) Kiss1 (show KISS1 Antibodies) cells that express GLP-1R, and GLP-1R signaling directly activates ARC (show NOL3 Antibodies) Kiss1 (show KISS1 Antibodies) function in an estradiol-independent manner. Pharmacological activation of GLP-1R signaling during fasting or pharmacological inhibition of CNS GLP-1R signaling during normal feeding does not alter circulating luteinizing hormone levels.
The increased calcium response mediated by secretin (show SECR Antibodies) in the absence of GLP-1R was paralleled by an increased glucose-dependent insulin (show INS Antibodies) response, indicating that the heterodimeric receptor complexes modulate secretin (show SECR Antibodies) responses.
Menin and PRMT5 (show PRMT5 Antibodies) suppress GLP1R transcript levels and PKA-mediated phosphorylation of FOXO1 (show FOXO1 Antibodies) and CREB (show CREB1 Antibodies).
Glp1r knockdown reduced anxiety-like behavior, implicating paraventricular nucleus GLP-1 (show GCG Antibodies) signaling in behavioral stress reactivity
Enhanced beta-cell GLP-1R signaling contributes to improved glucose regulation after vertical sleeve gastrectomy by promoting increased glucose-stimulated insulin (show INS Antibodies) secretion.
Results suggest a detectable but only modest role for GLP-1R signaling in mediating the effects of Roux-en-Y gastric bypass and that this role is limited to its well-described action on glucose regulation.
induces insulin secretion\; mediates neuroendocrine signaling of feeding behavior\; mediates cardiovascular response and increased blood pressure
glucagon-like peptide 1 receptor
, glucagon-like peptide 1 receptor-like
, GLP-1 receptor
, pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1