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anti-Human HIC1 Antibodies:
anti-Mouse (Murine) HIC1 Antibodies:
anti-Rat (Rattus) HIC1 Antibodies:
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Human Polyclonal HIC1 Primary Antibody for ELISA, WB - ABIN4317303
Yu, Liu, Cui, Sui, Ji, Guan, Sun, Ji, Liu, Liu, Zhao, Yu, Jin, Bai, Geng, Xue, Qi, Lee, Fu: Identification of novel subregions of LOH in gastric cancer and analysis of the HIC1 and TOB1 tumor suppressor genes in these subregions. in Molecules and cells 2011
Cow (Bovine) Polyclonal HIC1 Primary Antibody for WB - ABIN2780783
Stöcklein, Smardova, Macak, Katzenberger, Höller, Wessendorf, Hutter, Dreyling, Haralambieva, Mäder, Müller-Hermelink, Rosenwald, Ott, Kalla: Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma. in Oncogene 2008
These results suggest that up-regulation of MVP (show MVP Antibodies) in multi-drug resistance (MDR) may involve chromatin remodeling.
Data show that secretion of IL-6 (show IL6 Antibodies) induced by loss of HIC1 activated STAT3 (show STAT3 Antibodies) through IL-6 (show IL6 Antibodies)/JAK (show JAK3 Antibodies) pathway and was associated with NSCLC progression.
The VNTR sequence near HIC1 could be a predictive marker for oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.
Therefore, our data identify HIC1 as a novel factor involved in B cell differentiation acting as an epigenetic repressor of CIITA (show CIITA Antibodies) transcription.
HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.
Data show that expression of hypermethylated in cancer 1 protein (HIC1) is downregulated in uveal melanoma.
HIC1 attenuates invasion and metastasis by inhibiting the IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) signalling pathway in human pancreatic ductal adenocarcinoma.
Epigenetic silencing of HIC1 promotes epithelial-mesenchymal transition and drives progression in esophageal squamous cell carcinoma via EphA2 (show EPHA2 Antibodies) signaling.
The tumor-suppressive function of Hic1 in colon is related to its inhibitory action on proproliferative signaling mediated by the Tlr2 (show TLR2 Antibodies) receptor present on tumor cells.
Results demonstrated an important role of HIC1 for the normal progression of cell cycle, and could affect the homeostasis of p53 (show TP53 Antibodies) as well as number of cell cycle-related genes, which may or may not be directly linked to p53 (show TP53 Antibodies).
We found that EVI1 (show MECOM Antibodies) and HIC1 colocalize in the nucleus, and their interaction is mediated by the amino terminal zinc finger binding domain of EVI1 (show MECOM Antibodies)
identify HIC1 as the first transcription factor in mammals able to recruit PRC2 to some target promoters through its interaction with Polycomb (show CBX2 Antibodies)-like proteins.
Data show that Hic1 expression is absent in polyps from DH mice, with concomitant increased expression of two transcriptional repression targets of Hic1, Sirt1 (show SIRT1 Antibodies) and Sox9 (show SOX9 Antibodies).
A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1 (show EFNA1 Antibodies).
mice disrupted in the germ line for only one allele of Hic1 develop many different spontaneous malignant tumors, including a predominance of epithelial cancers in males and lymphomas and sarcomas in females
In human osteosarcomas, hypermethylation of HIC1 is frequent only in tumors with p53 (show TP53 Antibodies) mutation
Inactivation of HIC1 results in upregulated SIRT1 (show SIRT1 Antibodies) expression in normal or cancer cells; this deacetylates and inactivates p53 (show TP53 Antibodies), allowing cells to bypass apoptosis and survive DNA damage.
For the Hic-1 gene, but not p16 (show CDKN2A Antibodies), the p53 (show TP53 Antibodies) gene might protect against aberrant methylation. The iNOS (show NOS2 Antibodies) gene might not be involved in methylation of the Hic-1 gene, whereas the promoter region of p16 (show CDKN2A Antibodies) could be prone to methylation in MEFs lacking the iNOS (show NOS2 Antibodies) gene.
This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants.
, hypermethylated in cancer 1 protein
, hypermethylated in cancer 1
, zinc finger and BTB domain-containing protein 29
, hypermethylated in cancer 1 protein-like