HIC1 antibody (N-Term)

Catalog No. ABIN2777507

This Rabbit Polyclonal antibody specifically detects HIC1 in WB. It exhibits reactivity toward Human, Rat, Mouse, Guinea Pig, Dog, Cow and Pig.It has been mentioned in 1 publication

Quick Overview for HIC1 antibody (N-Term) (ABIN2777507)

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Reactivity: Human, Rat, Mouse, Guinea Pig, Dog, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HIC1 Antibody

Binding Specificity: N-Term

Purpose: HIC1 Antibody - N-terminal region

Sequence: RRCSPLCGLD LSKKSPPGSA APERPLAERE LPPRPDSPPS AGPAAYKEPP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Human: 100%, Mouse: 85%, Pig: 100%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against HIC1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HIC1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31936-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-HIC1 antibody (ABIN2777507)

Stöcklein, Smardova, Macak, Katzenberger, Höller, Wessendorf, Hutter, Dreyling, Haralambieva, Mäder, Müller-Hermelink, Rosenwald, Ott, Kalla: "Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma." in: Oncogene, Vol. 27, Issue 18, pp. 2613-25, (2008) (PubMed).

Target Details for HIC1

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Alternative Name: HIC1

Background:

Background Information: HIC1 is a transcriptional repressor. HIC1 may act as a tumor suppressor. HIC1 may be involved in development of head, face, limbs and ventral body wall. Defects in HIC1 may be a cause of the facial dysmorphism and additional birth defects (except for liss

Gene Name: Hypermethylated in cancer 1

Alternative Symbols: hic-1, ZBTB29, ZNF901

Protein Name: Hypermethylated in cancer 1 protein

Molecular Weight: 74kDa

Gene ID: 3090

NCBI Accession: NP_006488

UniProt: Q14526

Pathways: Positive Regulation of Response to DNA Damage Stimulus