Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Data show no autoantibody production was detectable in surrogate light chain (SLC (show CCL21A Proteins)) components VpreB/CD179a and lambda5/CD179b (show IGLL1 Proteins) transgenic mice.
VpreB probes the fitness of newly generated VH domains of IgH chains for later pairing with IgL chains, and its non-Ig part fixes the preBCRs on the surface.
Mice triply deficient for VpreB1 show B cell developmental defects but functional allelic exclusion of the IgH locus.
To identify the sequences that regulate lambda5 and VpreB1 (show IGLL1 Proteins) expression during B cell development, the DNaseI (show DNASE1 Proteins) hypersensitive sites in the lambda5-VpreB1 (show IGLL1 Proteins) functional domain were mapped.
Multiple receptor-dependent mechanisms operating at all stages of B cell development limit the contribution of B cells with Dmu (show SCN8A Proteins) heavy chain alleles to the repertoire.
mouse homolog forms a surrogate light chain in the pre-B cell receptor and plays a role in B-cell proliferation and expansion
immunoglobulin iota chain
, Immunoglobulin lambda Vpreb1 chain
, pre-B lymphocyte gene 1