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OPRD1 promoter hypermethylation is associated with the risk of AD
After inhibition of the PKC/ERK signalling pathway, the effects of DOR on breast cancer were significantly attenuated in vivo and in vitro. In summary, DOR is highly expressed in breast cancer and is closely related to its progression. These results suggest that DOR may serve as a potential biomarker for the early diagnosis of breast cancer and may be a viable molecular target for therapeutic intervention.
The study successfully developed a population PKPD model for oxycodone across three experimental pain types and investigated the association between 18 SNPs across all three opioid receptor genes (OPRM1 (show OPRM1 ELISA Kits), OPRK1 (show OPRK1 ELISA Kits), OPRD1) and analgesic response from oxycodone. None of the selected polymorphisms were significantly associated with analgesic response of oxycodone.
the expression of DOR was upregulated in the drugresistant human hepatocellular carcinoma cells.
OPRD-mediated activation of ERK1/2 (show MAPK1/3 ELISA Kits) is via ligand-specific transactivation of EGFR (show EGFR ELISA Kits).
findings suggest that SNPs in opioid receptors and the PNOC (show PNOC ELISA Kits) genes are associated with NAS (show SCN9A ELISA Kits) severity.
TMED6-COG8 chimera might act as a novel diagnostic marker in TFE3 translocation renal cell carcinoma.
We have established a delta opioid receptor-PKC-Nrf2 (show GABPA ELISA Kits) axis as a part of the mechanism underlying cytoprotection against hypoxia/reoxygenation injury
Targeted silencing of components of lobe B of the COG (show TG ELISA Kits) complex, namely COG5 (show COG5 ELISA Kits), COG6 (show COG6 ELISA Kits), COG7 (show COG7 ELISA Kits) and COG8 (show COG8 ELISA Kits), inhibited HIV-1 replication
Analysis of the transcription factor POU2F3 (show POU2F3 ELISA Kits) revealed a DOPr-mediated extracellular signal-regulated kinase (ERK (show EPHB2 ELISA Kits))-dependent downregulation of this factorThe delta-opioid receptor affects epidermal homeostasis
Delta opioid receptor (DOR) expressed in the forebrain mediate the described locomotor effect of SNC80 (DOR agonist) and inhibit D1-stimulated hyperactivity. Data also reveals an anxiogenic role for this particular DOR subpopulation.
Anti-nociception mediated by a KOR agonist is blocked by a DOR agonist
we have demonstrated for the first time that DOR receptor activation induces astrocytic expression of EAAT1 (show SLC1A3 ELISA Kits) and EAAT2 (show SLC1A2 ELISA Kits)
The results of this study indicated that delta-opioid receptor have a differential role in cue-induced reinstatement of cocaine-seeking behavior.
findings show that, during prolonged heroin abstinence, delta opioid receptors regulate hedonic homeostasis, while mu opioid receptor (show OPRM1 ELISA Kits) signaling in serotonergic pathways and kappa opioid receptors together control social behaviors
a role for differential modulation of opioid receptor signaling by post-endocytic processing of peptide agonists by ECE2 (show ECE2 ELISA Kits).
SSTR4 and delta-Opioid receptor (dOR) exist in a heteromeric complex and function in synergistic manner.
Our study suggests that MOR(mu opioid receptors) and DOR(delta opioid receptors are involved in the interactions between cocaine and both deltorphins analogs
prolonged hypoxia down-regulates BDNF (show BDNF ELISA Kits)-TrkB (show NTRK2 ELISA Kits) signaling leading to an increase in TNF-alpha (show TNF ELISA Kits) in the cortex, while delta-opioid receptor activation up-regulates BDNF (show BDNF ELISA Kits)-TrkB (show NTRK2 ELISA Kits) signaling thereby decreasing TNF-alpha (show TNF ELISA Kits) levels in the hypoxic cortex.
This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance.
COG complex subunit 8
, conserved oligomeric Golgi complex subunit 8
, conserved oligomeric golgi complex component 8
, dependent on RIC1
, delta-type opioid receptor
, opioid receptor A
, delta opioid receptor 1
, delta 1 opioid receptor
, Delta-type opioid receptor
, delta opioid receptor