DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1) protein (GST tag)

Details for Product No. ABIN1046949
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Protein Name
Synonyms NC2-alpha, 2310074H19Rik, fb26e10, zgc:56003, zgc:77337, wu:fb26e10, DRAP1
(7), (1), (1)
Escherichia coli (E. coli)
(4), (3), (2)
Protein Type Recombinant
Purification tag / Conjugate
GST tag
Pubmed 5 references available
Catalog no. ABIN1046949
Quantity 10 µg
327.80 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Discontinued
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Characteristics The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Ref.1 Ref.2
Purity 90%
Alternative Name Dr1-associated corepressor
Background Synonyms: Dr1-associated protein 1,Negative co-factor 2-alpha,NC2-alpha
Molecular Weight 48 kDa

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions For Research Use only
Buffer PBS buffer, 20mM GSH
Storage -20 °C
Product cited in: Mermelstein, Yeung, Cao et al.: "Requirement of a corepressor for Dr1-mediated repression of transcription." in: Genes & development, Vol. 10, Issue 8, pp. 1033-48, 1996 (PubMed).

Goppelt, Stelzer, Lottspeich et al.: "A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains." in: The EMBO journal, Vol. 15, Issue 12, pp. 3105-16, 1996 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Klejman, Pereira, van Zeeburg et al.: "NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein." in: Molecular and cellular biology, Vol. 24, Issue 22, pp. 10072-82, 2004 (PubMed).

Burkard, Planyavsky, Kaupe et al.: "Initial characterization of the human central proteome." in: BMC systems biology, Vol. 5, pp. 17, 2011 (PubMed).

Hosts (4), (3), (2)
Reactivities (7), (1), (1)
back to top