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DRAP1 Products

(DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1))
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008].

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Featured DRAP1 Categories

DRAP1 Antibodies

High quality antibodies with extensive validation data.

DRAP1 ELISA Kits

Reliable ELISA kits for a wide range of species.

DRAP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DRAP1 Antibodies

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Reactivity Human
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Cat. No. ABIN1538849
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Recommended DRAP1 ELISA Kits

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Cat. No. ABIN1130683
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Cat. No. ABIN1352008
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Cat. No. ABIN3129167
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Latest Publications for our DRAP1 products

Burkard, Planyavsky, Kaupe, Breitwieser, Bürckstümmer, Bennett, Superti-Furga, Colinge: "Initial characterization of the human central proteome." in: BMC systems biology, Vol. 5, pp. 17, (2011) (PubMed).

Klejman, Pereira, van Zeeburg, Gilfillan, Meisterernst, Timmers: "NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein." in: Molecular and cellular biology, Vol. 24, Issue 22, pp. 10072-82, (2004) (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).

Goppelt, Stelzer, Lottspeich, Meisterernst: "A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains." in: The EMBO journal, Vol. 15, Issue 12, pp. 3105-16, (1996) (PubMed).

Mermelstein, Yeung, Cao, Inostroza, Erdjument-Bromage, Eagelson, Landsman, Levitt, Tempst, Reinberg: "Requirement of a corepressor for Dr1-mediated repression of transcription." in: Genes & development, Vol. 10, Issue 8, pp. 1033-48, (1996) (PubMed).

Synonyms and alternative names related to DRAP1

DR1-associated protein 1 (negative cofactor 2 alpha) (drap1), DR1 associated protein 1 (DRAP1), Dr1 associated protein 1 (negative cofactor 2 alpha) (Drap1), Dr1 associated protein 1 (Drap1), 2310074H19Rik, DRAP1, fb26e10, NC2-alpha, wu:fb26e10, zgc:56003, zgc:77337

Protein level used designations for DRAP1

  • dr1-associated corepressor
  • DR1-associated protein 1 (negative cofactor 2 alpha)
  • NC2-alpha
  • dr1-associated protein 1
  • negative co-factor 2-alpha
  • negative cofactor 2 alpha
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