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Within the first 3h of infection with influenza virus, significant down-regulation of hsa (show CD24 Proteins)-miRNA-4276 is followed by a 2-fold increase in cytochrome c oxidase VIc mRNA was found to occur in human alveolar and bronchial epithelial cells.
Data indicate that recombinant (r)IL-24 (show IL24 Proteins) stimulated the mitochondrial apoptotic pathway genes Bax (show BAX Proteins), Bid (show BID Proteins), Casp8 (show CASP8 Proteins), COX6C, COX7B (show COX7B Proteins) after 36 h.
Data found that subunits Cox6a (show COX6A1 Proteins), Cox6b (show COX6B1 Proteins) and Cox7a (show COX7A1 Proteins) assembled into pre-existing complex IV, while Cox4-1 (show COX4I1 Proteins) and Cox6c subunits assembled into subcomplexes that may represent rate-limiting intermediates.
Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12.
cytochrome c oxidase subunit VIc
, cytochrome c oxidase subunit 6C
, cytochrome c oxidase subunit VIc a
, cytochrome c oxidase subunit VIc b
, cytochrome C oxidase subunit VIc
, OXPHOS complex IV polypeptide VIC
, cytochrome c oxidase VIc
, cytochrome c oxidase polypeptide VIc
, subunit VIc
, cytochrome c oxidase polypeptide VIc-like
, Cytochrome c oxidase polypeptide VIc
, cytochrome c oxidase subunit VIc preprotein
, cytochrome c oxidase polypeptide VIc-2
, cytochrome c oxidase subunit 6C-2
, cytochrome oxidase subunit VIc