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Low aortic mitochondria-encoded COX1 in obese diabetic double knock-out mice was associated with a larger plaque area and higher M1 macrophages and oxidized LDL. Caloric restriction increased COX1 and reduced plaque area and oxidized LDL. Low COX1 related to low expression of PPAR alpha (show PPARA Proteins), delta, and gamma and of peroxisome proliferative activated receptor, gamma, co-activator 1 alpha reflecting mitochondrial dysfunction.
CTPS1 inhibition selectively blocks smooth muscle cell proliferation without disturbing or even promoting re-endothelialization for effective vascular repair after injury.
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
a dependence of COX1 AND capital ES, CyrillicOX2 expression on the presence of MMP-9 (show MMP9 Proteins) was shown in neutrophil infiltration during inflammation.
CCOI expression is inhibited by osteopontin (show SPP1 Proteins) as the result of a novel CD44 (show CD44 Proteins)-dependent transcriptional regulatory mechanism of the mitochondrial H strand
The gene expression of Cox1 in adipocytes was studied.
CcOX (show COX5A Proteins) I protein levels significantly decreased following CO exposure while enzyme turnover number and CcOX (show COX5A Proteins) I mRNA levels remained unchanged.
IOP elevation may directly damage mitochondria in the ONH axons by promoting reduction of COX (show CPOX Proteins), mitochondrial fission and cristae depletion, alterations of OPA1 and Dnm1 (show DNM1 Proteins) expression, and induction of OPA1 release.
Tumor necrosis factor alpha (show TNF Proteins) inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c (show CYCS Proteins) oxidase
The filament structures elucidate allosteric mechanisms of assembly and regulation that rely on a conserved conformational equilibrium. The findings may provide a mechanism for increasing human CTP synthase activity in response to metabolic state and challenge the assumption that metabolic filaments are generally storage forms of inactive enzymes.
Rods and rings (RR) are protein assemblies composed of CTPS1 and IMPDH2. Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
results highlight a key and specific role of CTPS1 in the immune system by its capacity to sustain the proliferation of activated lymphocytes during the immune response
analysis of the kinetic properties of hCTPS1 and hCTPS2, and determination that Ser (show SIGLEC1 Proteins)(68) is a major site of CTPS2 (show CTPS2 Proteins) regulation by phosphorylation
CTP synthetase (show CTPS2 Proteins) is phosphorylated by protein kinase A
Data indicate that protein kinase C phosphorylation at Ser (show SIGLEC1 Proteins)(462) stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr (show TRH Proteins)(455) inhibits activity.
analysis of phosphorylation and regulation of human CTPS1 in human cells shows that GSK3 is a novel regulator of CTPS activity
studies provide novel information on the potential interacting proteins that may regulate CTPS1 function or intracellular localization
The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types
, CTP synthase 1
, CTP synthetase 1
, UTP--ammonia ligase 1
, cytidine 5'-triphosphate synthase
, CTP synthase 1-B
, CTP synthetase 1-B
, UTP--ammonia ligase 1-B
, CTP synthase a
, cytidine 5'-triphosphate synthetase
, cytidine 5-prime triphosphate synthetase
, CTP synthase 1-like
, CTP synthetase