ICAM1 antibody

Catalog No. ABIN2191981

This Mouse Monoclonal antibody specifically detects ICAM1 in FACS, IP, IHC (p), IHC (fro), StM and IA. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for ICAM1 antibody (ABIN2191981)

Target: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ICAM1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Staining Methods (StM), Immunoassay (IA)

Clone: HM-2

Product Details anti-ICAM1 Antibody

Sterility: 0.2 μm filtered

Application Details

Application Notes: For immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Handling

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Expiry Date: 12 months

References for anti-ICAM1 antibody (ABIN2191981)

van de Stolpe, van der Saag: "Intercellular adhesion molecule-1." in: Journal of molecular medicine (Berlin, Germany), Vol. 74, Issue 1, pp. 13-33, (1996) (PubMed).

Sligh, Ballantyne, Rich, Hawkins, Smith, Bradley, Beaudet: "Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 18, pp. 8529-33, (1993) (PubMed).

Target Details for ICAM1

Target: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Background: The monoclonal HM.2 antibody reacts with the 90 kD glycoprotein Intracellular Adhesion Molecule-1 (ICAM-1). The adhesion molecule ICAM-1 belongs to the immunoglobulin superfamily, C2 subset, it is a ligand for the Integrins LFA-1 and MAC-1 and for CD43. ICAM-1 is an essential component in many immune-related processes. ICAM-1 links with receptors of the integrin family, thereby mediating cell-cell interactions and allowing for signal transduction. ICAM-1 interacts specifically with its receptors to induce a reversible adhesion interaction. For processes like T cell activation and leucocyte recruitment, normal immune function relies on ICAM-1. Therefore, it is understandable that alterations in ICAM-1 structure or expression are associated with immune disorders. It is important to properly understand the various functions and regulatory mechanisms of ICAM-1, the resulting disease-related failures, and the various treatments. ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFalpha) and is expressed by the vascular endothelium, macrophages and lymphocytes Aliases ICAM-1, CD54

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling