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Human Polyclonal SLIT2 Primary Antibody for IHC, IHC (p) - ABIN4354558
Yu, Cao, Yu, Wu, Dallol, Li, Chen, Grasso, Cao, Lonigro, Varambally, Mehra, Palanisamy, Wu, Latif, Chinnaiyan: The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer. in Oncogene 2010
Show all 3 Pubmed References
Human Polyclonal SLIT2 Primary Antibody for IHC (p), IHC - ABIN251500
Lin, Rao, Isacson: Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons. in Molecular and cellular neurosciences 2005
The alteration of Slit2 (show SLIT3 Antibodies) and Robo1 (show ROBO1 Antibodies) expression in the retinas of diabetic rats and patients with proliferative diabetic retinopathy suggests a role for the Slit-Robo signal in the various stages diabetic retinopathy.
human placental multipotent mesenchymal stromal cell express Slit2 (show SLIT3 Antibodies) and both Robo1 (show ROBO1 Antibodies) and Robo4 (show ROBO4 Antibodies) are present in human umbilical vein endothelial cells.
Slit2 (show SLIT3 Antibodies)-Robo1 (show ROBO1 Antibodies) signaling promoted the adhesion, invasion and migration of tongue carcinoma cells by upregulating the expression levels of MMP2 (show MMP2 Antibodies) and MMP9 (show MMP9 Antibodies) and, downregulating the expression of E-cadherin (show CDH1 Antibodies).
findings suggest that AK3 and SLIT2 may be potential candidates involved in genetic susceptibility to colorectal cancer
Low Slit2 expression is associated with glioma.
Results indicate the importance of SLIT2 (show SLIT3 Antibodies)-ROBO1 (show ROBO1 Antibodies)-CDC42 (show CDC42 Antibodies) signaling pathway in predicting tumor progression.
We postulate that Robo1 (show ROBO1 Antibodies) promotes tumor invasion partly by the upregulation of MMP2 (show MMP2 Antibodies) after activation of PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway. Notably, Slit2 (show SLIT3 Antibodies) knockdown caused the upregulation of Robo1 (show ROBO1 Antibodies) expression both at the mRNA and protein levels. Thus, the stimulatory effects of Slit2 (show SLIT3 Antibodies) knockdown on tumor progression can be ascribed, at least in part, to the upregulation of Robo1 (show ROBO1 Antibodies) and its positive role in tumor progression.
expression of the evolutionarily conserved slit2 (show SLIT3 Antibodies) Gene Promoter Requires Sp1 (show PSG1 Antibodies)
Study shows that Slit2 (show SLIT3 Antibodies) mRNA and protein levels were significantly reduced in papillary thyroid cancer (PTC (show F9 Antibodies)) specimens and implicates Slit2 (show SLIT3 Antibodies) functions as a negative regulator in the development and progression of PTC (show F9 Antibodies).
Overexpression of Slit2 induces its tumor suppressive effects in Breast cancer.
While Slit1 (show SLIT1 Antibodies) and Robo2 (show ROBO2 Antibodies) are only expressed in peripheral axons and their cell bodies, Slit2, Slit3 (show SLIT3 Antibodies) and Robo1 (show ROBO1 Antibodies) are also expressed in satellite cells of the dorsal root ganglion, Schwann cells and fibroblasts of peripheral nerves.
Transgenic over-expression of slit2 enhances disruption of blood-brain barrier and increases cell death after traumatic brain injury in mice. This suggest that over expression of slit2 plays a detrimental role in the pathophysiology of mild TBI.
Slit2 induces a robust activation of PKA signaling, which is required for its prothermogenic activity.
Robo1-Slit2 interaction required for pathfinding mechanism essential to establish the functionally important habenulo-interpeduncular connection.
Together, these observations suggest that Slit2 serves as a factor utilized by muscle Ctnnb1 (show CTNNB1 Antibodies) to direct presynaptic differentiation.
Slit2 acts as a repellant cue to mediate axon guidance in the formation of the anterior commissure.
Slit2/Robo1 (show ROBO1 Antibodies) signaling promotes intestinal tumorigenesis through Src (show SRC Antibodies)-mediated activation of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway.
the two genes neuropeptide Y (Npy (show NPY Antibodies)) and Slit homolog 2 (Drosophila) (Slit2) gradually increase during aging, and upon suppression of these two genes
Data shows that modulation of angiostatic factor Slit2 by EphA2 receptor regulates endothelial responses to VEGF-mediated angiogenesis and tumor neovascularization.
administration of Slit2 to atherosclerosis-prone LDL receptor (show LDLR Antibodies)-deficient mice inhibited monocyte recruitment to nascent atherosclerotic lesions.
These data supports a model whereby Wnt signaling through Frizzled-3a attenuates expression of Slit2 in the rostral midline of the forebrain.
In embryonic axon tracts, Robo2 (show ROBO2 Antibodies) responds to signals from slit2 and slit3 (show SLIT3 Antibodies).
Data show that Hedgehog (show SHH Antibodies) signaling is required for commissure formation, glial bridge formation, and the restricted expression of the guidance molecules slit1a, slit2, slit3 (show SLIT3 Antibodies) and sema3d (show SEMA3D Antibodies).
Slit acts via Robo2 (show ROBO2 Antibodies) in dendrites as a branching/growth factor but not in guidance, while Robo2 (show ROBO2 Antibodies) and Robo3 (show ROBO3 Antibodies) function in concert in axons to mediate axonal interactions and respond to Slits as guidance factors
Combining Slit2 with VEGFs adjusts VEGFR2 (show KDR Antibodies)-mediated angiogenic effects into a more physiological direction
acts as a ligand for glypican-1, a heparan sulfate proteoglycan\; may play a role in neurogenesis and midline development
slit homolog 2 protein
, downregulated during adipocyte differentiation-1
, neurogenic extracellular slit protein
, slit homolog 2 (Drosophila)