Browse our Tropomyosin 1 (Alpha) Proteins (TPM1)

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Tropomyosin 1 (Alpha) Proteins (TPM1)
On are 41 Tropomyosin 1 (Alpha) (TPM1) Proteins from 9 different suppliers available. Additionally we are shipping Tropomyosin 1 (Alpha) Antibodies (88) and Tropomyosin 1 (Alpha) Kits (2) and many more products for this protein. A total of 139 Tropomyosin 1 (Alpha) products are currently listed.
AA986836, AI854628, alpha-fTM, alpha-tm, alpha-tropomyosin, C15orf13, CH1, CMD1Y, CMH3, fb37a09, HTM-alpha, MGC84844, tm, TM2, Tm3, Tm7, Tma2, Tmpa, TMSA, Tpm-1, TPM1, TPMA, wu:fb37a09
list all proteins Gene Name GeneID UniProt
TPM1 22003 P58771
TPM1 24851 P04692
TPM1 7168 P09493

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Tropomyosin 1 (Alpha) Proteins (TPM1) by Origin

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Top referenced Tropomyosin 1 (Alpha) Proteins

  1. Human TPM1 Protein expressed in Escherichia coli (E. coli) - ABIN667191 : Perry: Vertebrate tropomyosin: distribution, properties and function. in Journal of muscle research and cell motility 2001 (PubMed)
    Show all 2 references for 667191

More Proteins for Tropomyosin 1 (Alpha) Interaction Partners

Rabbit Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. The results indicate that cross-linking significantly affects properties of Tpm (show TPMT Proteins) and actin-myosin interaction and can explain, at least partly, the role of the interchain disulfide cross-linking of cardiac Tpm (show TPMT Proteins) in human heart diseases.

  2. altered TM-actin contacts destabilized the thin filament and affected the actin-myosin interactions

  3. analysis of the thin filament associated with the R167H and K168E substitutions in tropomyosin (show TPM2 Proteins) Tpm1.1

  4. We propose that TR100 acts to compromise the integrity of Tpm cables rather than prevent overlap complex formation. Our data suggests that TR100 is incorporated into the growing actin-Tpm co-polymer given that its effects cannot be observed on pre-formed Tpm3.1/actin filaments

  5. Maximal Ca(2 (show CA2 Proteins)+) activated force was the same in alphaalphaTm versus betabetaTm myofibrils, but betabetaTm myofibrils showed a marked slowing of relaxation and an impairment of regulation under resting conditions

  6. Tmod1 (show TMOD1 Proteins) and Tmod3 (show TMOD3 Proteins) showed somewhat different tropomyosin (show TPM2 Proteins)-binding site utilization.

  7. Thermal denaturation of rabbit cardiac alpha,alpha-tropomyosin is monitored at neutral pH and compared to shark tropomyosin (show TPM2 Proteins), showing that amino acid substitutions predicted to be unfavorable in one temperature regime are desirable in another.

  8. The rotational motion of a spin label covalently bound to the side chain of a cysteine genetically incorporated into rabbit skeletal muscle tropomyosin (show TPM2 Proteins), was measured.

  9. a computational search assessing electrostatic interactions for multiple azimuthal locations, z-positions, and pseudo-rotations of tropomyosin on F-actin was performed.

Human Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. data demonstrate that the K15N mutation alters pointed end dynamics by affecting molecular interactions between Tpm1.1, Lmod2 (show LMOD2 Proteins) and Tmod1 (show TMOD1 Proteins).

  2. Results report evidence for the existence of variants in LHFPL2 (show LHFPL2 Proteins) and TPM1 with low allele frequencies and large effects on age-at-onset of familial Parkinson's disease.

  3. In diabetes, expression of high molecular weight (HMW) isoforms from tropomyosin 1 (TPM1) were markedly decreased but HMW isoforms from tropomyosin 4 (TPM4 (show TPM4 Proteins)) were not significantly different.

  4. results suggest that TPM1 can suppress tumors in oral squamous cell carcinoma, and the TPM1 expression level is related to oral squamous cell carcinoma patient prognosis

  5. Data suggest that the tropomyosin (show TPM2 Proteins) overlap region structure and function are affected differentially by a point mutation in cardiac tropomyosin (TPM1, D230N) that is associated with dilated cardiomyopathy as compared to a point mutation in cardiac troponin T (TNNT2 (show TNNT2 Proteins), R92L) that is associated with hypertrophic cardiomyopathy.

  6. Data indicate that various hypertrophic cardiomyopathy (HCM) mutations can differently affect the structural and functional properties of tropomyosin (show TPM2 Proteins) (Tpm (show TPMT Proteins)) and cause HCM by different molecular mechanisms.

  7. Promoter variants in HOXA9 (show HOXA9 Proteins), TPM1, and TPM2 (show TPM2 Proteins), alter promoter expression suggesting that they have a functional role in clubfoot.

  8. The TPM1 mutations D175N and E180G increased the sliding velocity and its calcium sensitivity of the actin-myosin Interaction, while mutation E40K reduced both these parameters.

  9. No association was observed between the remaining three markers (rs11071720, rs3803499, and rs12148828) and NSOC as well as its subgroups. TPM1 polymorphisms might contribute to the etiology ofnonsyndromic orofacial clefts (NSOC), , and more emphasis should be placed on TPM1 during craniofacial development

  10. We propose that TR100 acts to compromise the integrity of Tpm cables rather than prevent overlap complex formation. Our data suggests that TR100 is incorporated into the growing actin-Tpm co-polymer given that its effects cannot be observed on pre-formed Tpm3.1/actin filaments

Pig (Porcine) Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

Cow (Bovine) Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. The tendency of smooth muscle tropomyosin to form semi-rigid polymers with continuous and undampened rigidity may compensate for the lack of troponin-based structural support in smooth muscles.

  2. Deletion of regions 2-3 in tropomyosin (show TPM2 Proteins) alpha resulted in an 60 % decrease in both isometric tension and stiffness of tropomyosin (show TPM2 Proteins)-reconstituted myocardium.

  3. Tropomyosin (show TPM2 Proteins) is primarily responsible for the change in the kinetic constants of the elementary steps of the cross bridge cycle.

  4. Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules

Mouse (Murine) Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. The cMyBP-C hypertrophic cardiomyopathy variant L348P enhances thin filament activation through an increased shift in tropomyosin (show TPM2 Proteins) position.

  2. three-dimensional structure of F-actin at a resolution of 3.7 A in complex with tropomyosin (show TPM2 Proteins) at a resolution of 6.5 A, determined by electron cryomicroscopy

  3. data also identify a novel alphaTM1/Tmod1-based pathway stabilizing F-actin at cell-cell junctions, which may be required for maintenance of cell shapes during embryonic cardiac morphogenesis.

  4. This is the first study to demonstrate that decreasing phosphorylation of tropomyosin (show TPM2 Proteins) can rescue a hypertrophic cardiomyopathic phenotype.

  5. Tropomyosin (show TPM2 Proteins) dephosphorylation results in myocyte hypertrophy with increases in SERCA2a (show ATP2A2 Proteins) expression.

  6. The results identify a novel mode of myofilament desensitization to Ca(2 (show CA2 Proteins)+) associated with a DCM linked switch in TPM1-kappa.

  7. signaling by alpha-tropomyosin may have a role in familial hypertrophic cardiomyopathy

  8. A point mutation in alpha-TM causes a disease similar to familial hypertophic cardiomyopahy.

  9. PTB (show PTBP1 Proteins) interacting protein raver1 (show RAVER1 Proteins) regulates alpha-tropomyosin alternative splicing.

  10. the N terminus is a critical determinant of TM1 (show TPM2 Proteins) functions, which in turn determines the organization of stress fibers.

Tropomyosin 1 (Alpha) (TPM1) Protein Profile

Protein Summary

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.

Alternative names and synonyms associated with Tropomyosin 1 (Alpha) (TPM1)

  • tropomyosin 1 (alpha) (TPM1)
  • tropomyosin (LOC100101174)
  • tropomyosin (tm7)
  • tropomyosin 1, alpha (Tpm1)
  • alpha-tropomyosin (tpma)
  • tropomyosin 1 (alpha) (tpm1)
  • alpha-tropomyosin (LOC100125989)
  • tropomyosin (Smp_044010.2)
  • tropomyosin 1 (LOC732984)
  • AA986836 protein
  • AI854628 protein
  • alpha-fTM protein
  • alpha-tm protein
  • alpha-tropomyosin protein
  • C15orf13 protein
  • CH1 protein
  • CMD1Y protein
  • CMH3 protein
  • fb37a09 protein
  • HTM-alpha protein
  • MGC84844 protein
  • tm protein
  • TM2 protein
  • Tm3 protein
  • Tm7 protein
  • Tma2 protein
  • Tmpa protein
  • TMSA protein
  • Tpm-1 protein
  • TPM1 protein
  • TPMA protein
  • wu:fb37a09 protein

Protein level used designations for Tropomyosin 1 (Alpha) Proteins (TPM1)

alpha-tropomyosin 1 , alpha-tropomyosin 2 , alpha-tropomyosin of skeletal fast muscle , tropomyosin (CTm4) , tropomyosin (CTm7) , tropomyosin alpha-1 chain , tropomyosin-1 , actotropomyosin , tropomyosin-2 , tropomyosin , Tropomyosin-1 alpha chain , tropomyosin 1 alpha chain , alpha tropomyosin , alpha-tropomyosin , hepatoma alpha tropomyosin , smooth muscle alpha-tropomyosin , striated muscle alpha-tropomyosin , tropomyosin 3 alpha , alpha-skeletal tropomyosin , cardiomyopathy, hypertrophic 3 , sarcomeric tropomyosin kappa , tropomyosin 1 (alpha) isoform 1 , tropomyosin 1 (alpha) isoform 2 , tropomyosin 1 (alpha) isoform 3 , tropomyosin 1 (alpha) isoform 4 , tropomyosin 1 (alpha) isoform 5 , tropomyosin 1 (alpha) isoform 6 , tropomyosin 1 (alpha) isoform 7

396366 Gallus gallus
100101174 Bombyx mori
431788 Xenopus laevis
281544 Bos taurus
22003 Mus musculus
24851 Rattus norvegicus
30324 Danio rerio
100189579 Xenopus laevis
7168 Homo sapiens
478332 Canis lupus familiaris
100037999 Sus scrofa
100125989 Oryctolagus cuniculus
8350314 Schistosoma mansoni
732984 Bombyx mori
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