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anti-Human IER3 Antibodies:
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Human Polyclonal IER3 Primary Antibody for IHC, ELISA - ABIN1002470
Kondratyev, Chung, Jung: Identification and characterization of a radiation-inducible glycosylated human early-response gene. in Cancer research 1996
Show all 4 Pubmed References
Human Polyclonal IER3 Primary Antibody for ELISA, ICC - ABIN4321045
Akilov, Wu, Ustyugova, Falo, Geskin: Resistance of Sézary cells to TNF-α-induced apoptosis is mediated in part by a loss of TNFR1 and a high level of the IER3 expression. in Experimental dermatology 2012
Human Polyclonal IER3 Primary Antibody for FACS, IF - ABIN655735
Fellay, Ge, Shianna, Colombo, Ledergerber, Cirulli, Urban, Zhang, Gumbs, Smith, Castagna, Cozzi-Lepri, De Luca, Easterbrook, Günthard, Mallal, Mussini, Dalmau, Martinez-Picado, Miro, Obel, Wolinsky, Martinson, Detels, Margolick, Jacobson, Descombes, Anton: Common genetic variation and the control of HIV-1 in humans. in PLoS genetics 2009
Show all 3 Pubmed References
we determined the molecular mechanism responsible for IER3 degradation, involving a ternary complex of IER3, MDM2 (show MDM2 Antibodies) and FHL2 (show FHL2 Antibodies), which may contribute to cervical tumor growth. Furthermore, we demonstrated that FHL2 (show FHL2 Antibodies) serves as a scaffold for E3 ligase and its substrate during the ubiquitination reaction, a function that has not been previously reported for this protein
Analysis of consensus EGR (show EGR1 Antibodies)-binding elements (EBEs) showed that the immediate early response 3 gene (IER3) is a novel transcriptional target gene of EGR2 (show EGR2 Antibodies) as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis.
Study characterized IEX-1's expression and function in rheumatoid arthritis synovial fibroblasts and showed that IEX-1 is highly expressed in RA-SFs and negatively regulates RA-SF activation.
interleukin-1beta (IL-1beta (show IL1B Antibodies))-induced IER3 expression is mediated by the ERK1/2 (show MAPK1/3 Antibodies) target, transcription factor Elk-1 (show ELK1 Antibodies).
findings suggest that IER3 is a putative tumor suppressor in the cervix, and the c-Ab1/p73beta/IER3 axis is a novel and crucial signaling pathway that confers etoposide chemosensitivity.
High expression of IER3 is associated with hepatocarcinoma.
In human samples removed from failed AVF, there was a significant increase in IEX-1 expression localized to the adventitia.
IEX-1 expression levels correlate with the severity of preeclampsia
Studied the binding effect of hcmv-miR (show MLXIP Antibodies)-UL148D to the 3' untranslated region (3'UTR (show UTS2R Antibodies)) of IEX-1.Results showed that only one binding site in the 3'UTR (show UTS2R Antibodies) of IEX-1 was completely complementary to an 11nt sequence in the 5' terminus of hcmv-mir (show MLXIP Antibodies)-UL148D.
the interference of IER3 with the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)-Fyn (show FYN Antibodies) pathway represents a novel mechanism of Nrf2 (show GABPA Antibodies) regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity.
IER3 expression is blunted during heart failure development in a titin (show TTN Antibodies)-deficient mouse model.
these results indicate that IER3 is a key player in expanding the pool of APC (show APC Antibodies) while highlighting the role of distinct effectors found in an obese microenvironment in this process
Loss of IEX-1 results in reduced VNH accompanied with a decrease in proliferation, reduced fibroblast, myofibroblast, and Ly6C staining accompanied with increased apoptosis mediated through a reduction in Vegf-A (show VEGFA Antibodies)/Mcp-1 (show CPT1B Antibodies) axis and Mmp-9 (show MMP9 Antibodies).
IER3 supports KRASG12D-associated oncogenesis in the pancreas by sustaining ERK1/2 (show MAPK1/3 Antibodies) phosphorylation via phosphatase PP2A (show PPP2R2B Antibodies) inhibition.
Stress-induced hematopoietic failure in the absence of immediate early (show JUN Antibodies) response gene X-1 (IEX-1, IER3).
the interference of IER3 with the PI3K/Akt (show AKT1 Antibodies)-Fyn (show FYN Antibodies) pathway represents a novel mechanism of Nrf2 (show NFE2L2 Antibodies) regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity.
IEX-1 has a role in activation of Erk (show EPHB2 Antibodies) and NF-kB pathways, which affects thrombopoietin (show THPO Antibodies)-promoted NHEJ DNA repair in hematopoietic stem cells
Data suggest a role for the immediate early (show JUN Antibodies) response gene X-1 (IEX-1) in the control of colon epithelial homeostasis.
Our present investigation shows that null mutation of IEX-1 promotes differentiation of Th17 cells but compromises the survival of Th1 (show HAND1 Antibodies) cells
IER3 plays a complex and to some extent contradictory role in cell cycle control and apoptosis. Effects of IER3 relate to an interference with certain signalling pathways
present data indicating that bovine IER3 is a strong regulator of immune-marker expression, specifically modulating bovine interleukin-8 (show IL8 Antibodies) activation through the NF-kappaB (show NFKB1 Antibodies)/IER3 pathway in response to the bovine viral diarrhea virus.
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.
PACAP-responsive gene 1 protein
, anti-death protein
, differentiation-dependent gene 2 protein
, expressed in pancreatic carcinoma
, gly96, mouse, homolog of
, immediate early protein GLY96
, immediate early response 3 protein
, immediately early gene X-1
, protein DIF-2
, radiation-inducible immediate-early gene IEX-1
, cAMP inducible gene 3
, immediate early response 3
, ATP-binding cassette, sub-family F (GCN20), member 1