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anti-Human SMEK1 Antibodies:
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Human Polyclonal SMEK1 Primary Antibody for ELISA, WB - ABIN261117
Panowski, Wolff, Aguilaniu, Durieux, Dillin: PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. in Nature 2007
sMEK1 significantly inhibited BMI-1 (show BMI1 Antibodies)-stimulated oncogenesis.
Loss of sMEK1 is associated with Ovarian Neoplasms.
The N-terminal of BLU was observed to interact with the C-terminal of SMEK1, a regulatory subunit of protein phosphatase 4. Furthermore, we determined the binding domains that are required for interaction between BLU and sMEK1. The N-terminal of BLU was observed to interact with the C-terminal of sMEK1.
Smek/Mbd3 (show MBD3 Antibodies) interaction regulates neuronal gene expression and neuronal differentiation during cortical development.
Authors identify the cell polarity protein Par3, a negative regulator of neuronal differentiation, as a Smek1 substrate and demonstrate that Smek1 suppresses its activity.
the Smek-containing protein phosphatase 4 complex represses transcription of Wnt (show WNT2 Antibodies)-responsive development-related genes through histone deacetylation, and that this complex is essential for embryonic stem cell pluripotency maintenance
Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
serine/threonine-protein phosphatase 4 regulatory subunit 3A
, SMEK homolog 1, suppressor of mek1