Browse our Cofilin 1 (Non-Muscle) Proteins (CFL1)

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Cofilin 1 (Non-Muscle) Proteins (CFL1)
On are 23 Cofilin 1 (Non-Muscle) (CFL1) Proteins from 12 different suppliers available. Additionally we are shipping Cofilin 1 (Non-Muscle) Antibodies (310) and Cofilin 1 (Non-Muscle) Kits (53) and many more products for this protein. A total of 397 Cofilin 1 (Non-Muscle) products are currently listed.
12/8, AA959946, Adf, ADF/cofilin, Cadf, cb86, CFL, CFL1, CG4254, Cof, cofilin, cofilin/actin depolymerizing factor homolog, cofilin/ADF, D-cof, D61, Dmel\\CG4254, l(2)03101, l(2)k03101, l(2)k05633, l(2)k13409, ntf, sb:cb86, T8, Tsr, wu:fb18a04, wu:fk77b03, xac1, xac2, zgc:56501
list all proteins Gene Name GeneID UniProt
CFL1 1072 P23528
CFL1 12631 P18760
CFL1 29271 P45592

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Cofilin 1 (Non-Muscle) Proteins (CFL1) by Origin

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Top referenced Cofilin 1 (Non-Muscle) Proteins

  1. Human CFL1 Protein expressed in Escherichia coli (E. coli) - ABIN666701 : Mannherz, Ballweber, Galla, Villard, Granier, Steegborn, Schmidtmann, Jaquet, Pope, Weeds: Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array: evidence for a second binding site on monomeric actin. in Journal of molecular biology 2007 (PubMed)
    Show all 3 references for 666701

  2. Human CFL1 Protein expressed in Escherichia coli (E. coli) - ABIN2006220 : Ichetovkin, Han, Pang, Knecht, Condeelis: Actin filaments are severed by both native and recombinant dictyostelium cofilin but to different extents. in Cell motility and the cytoskeleton 2000 (PubMed)

More Proteins for Cofilin 1 (Non-Muscle) Interaction Partners

Xenopus laevis Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. Results suggest that elevation of actin dynamics by Xenopus ADF/cofilin (XAC) activation through Slingshot phosphatase (XSSH) phosphorylation is required for meiotic spindle assembly.

  2. Gastrulation movement requires ADF/cofilin activity through dynamic regulation of its phosphorylation state.

Zebrafish Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. proper actin turnover mediated by Cfl1 is essential for adhesion between the deep cell layer and the enveloping layer and cell movements during gastrulation in zebrafish

  2. Silencing of cofilin-1 led to an Accumulation of F-actin fibers and significantly decreased podocyte migration. ability

Fruit Fly (Drosophila melanogaster) Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. Mical and cofilin, therefore, form a redox-dependent synergistic pair that promotes F-actin instability by rapidly dismantling F-actin and generating post-translationally modified actin that has altered assembly properties

  2. Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.

  3. AIP1 enhances cofilin-mediated actin disassembly in the apical region of precluster cells to promote remodeling of adherense junctions.

  4. Data show that cofilin is required for F-actin turnover and lamellipodial protrusion in the border cells.

  5. tsr is required for planar cell polarity patterning.

  6. These results indicate that changes in the extent of cofilin phosphorylation are regulated by Ssh in response to changes in the levels and/or organisation of F-actin.

  7. Results show that twinstar (tsr), which encodes Drosophila cofilin/ADF (actin-depolymerizing factor), is required for elongation of the retinal cell body and the morphogenesis of the rhabdomere.

Human Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. Report structural basis for noncanonical substrate recognition of cofilin-1/LIMK1 to regulation actin cytoskeleton dynamics.

  2. STMN1 (show STMN1 Proteins),COF1 and PAIRBP1 (show SERBP1 Proteins) thus represent proteins associated with proliferative and aggressive tumors of high grades, while TSP2 (show THBS2 Proteins) and POSTN (show POSTN Proteins) were connected to low grade tumors with better prognosis

  3. We observed marked increases in LIM kinase 2 (LIMK2 (show LIMK2 Proteins)) and cofilin 1 (CFL1) gene expressions in metabolic syndrome patients.

  4. Therefore, miR (show MLXIP Proteins)-138/LIMK1 (show LIMK1 Proteins)/cofilin may be considered a potential therapeutic target for the treatment of non-small cell lung cancer

  5. These findings indicate that inhibition of the Rac1WAVE2Arp2/3 signaling pathway may promote radiosensitivity, which may partially result from the downregulation of CFL1 (show VPS72 Proteins) in U251 human glioma cells.

  6. The present findings demonstrated that the anticancer effect of docetaxel induces the apoptosis of prostate cancer via the suppression of the cofilin1 and paxillin (show PXN Proteins) signaling pathways, which will assist in setting a stage for the clinical treatment of prostate cancer.

  7. VEGFA (show VEGFA Proteins) induced phosphorylation of Pak1 (show PAK1 Proteins) and its effector cofilin in a manner that was dependent on time as well as p38MAPKbeta.

  8. CFL1 (show VPS72 Proteins) itself does not translocate actin into the cell nucleus but this transport requires the functional expression of IPO9 (show IPO9 Proteins).

  9. Abnormal CFL1 (show VPS72 Proteins) expression may affect vulvar carcinogenesis and subsequent progression.

  10. PAK1 (show PAK1 Proteins)-cofilin phosphorylation mechanism to mediate lung adenocarcinoma cells migration promoted by apelin (show APLN Proteins)-13

Cow (Bovine) Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. Myosin phosphatase and cofilin mediate cAMP/cAMP-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin II regulatory light chain phosphorylation

  2. Cyclic compression for 10 min up-regulated gene expression for the actin depolymerising proteins, cofilin and destrin (show DSTN Proteins).

Mouse (Murine) Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. the Rap1-cofilin-1 pathway coordinates actin and microtubule organization at the immune synapse.

  2. VEGFA (show VEGFA Proteins) induced phosphorylation of Pak1 (show PAK1 Proteins) and its effector cofilin in a manner that was dependent on time as well as p38MAPKbeta.

  3. Data show that the primary effect of costimulation blockade was to decrease recruitment of the activator of actin nucleation WAVE2 (Wiskott-Aldrich syndrome protein family member protein 2) and cofilin (actin-severing protein) to F-actin.

  4. These results strongly support the active role of cofilin in ischemia-induced neuronal degeneration and apoptosis.

  5. Caspase-11 (show CASP4 Proteins) targets cofilin via the RhoA GTPase, whereas caspase-1 (show CASP1 Proteins) engages the Slingshot phosphatase

  6. aberrant cofilin phosphorylation that induces actin polymerization might be a consequence of actin disassembly induced by the absence of Rac1.

  7. novel roles for actin-depolymerizing factor (show DSTN Proteins) and cofilin-1 in regulating the remodeling and permeability of epithelial junctions

  8. reelin (show RELN Proteins) and cofilin cooperate in controlling cytoskeletal dynamics during neuronal migration.

  9. The data of this study identify overlapping functions for ADF (show TXN Proteins) and n-cofilin in presynaptic physiology and vesicle in mice. trafficking.

  10. Actin depolymerizing factor/cofilin double mutant mice exhibited hyperlocomotion, impulsivity, and impaired working memory. Hyperlocomotion and impulsive behavior were reversed by methylphenidate.

Pig (Porcine) Cofilin 1 (Non-Muscle) (CFL1) interaction partners

  1. In vitro, formation of cofilin oligomers was drastically reduced after phosphorylation by LIMK2 (show LIMK2 Proteins).

  2. glucose increases p-cofilin by phosphorylating LIMK1 through activation of Rho/Rho kinase, probably due to diacylglycerol-sensitive PKC activation resulting from increased glucose influx

  3. Cofilin is necessary for maintaining the osmotic responsiveness of the cytoskeleton in tubular cells, and the Rho/ROCK/LIMK-mediated cofilin phosphorylation is a key mechanism in the hyperosmotic stress-induced F-actin increase.

Cofilin 1 (Non-Muscle) (CFL1) Protein Profile

Protein Summary

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.

Alternative names and synonyms associated with Cofilin 1 (Non-Muscle) (CFL1)

  • cofilin 1 (non-muscle) (cfl1-a)
  • cofilin 1 (non-muscle) (cfl1)
  • cofilin 1 (non-muscle) (CFL1)
  • twinstar (tsr)
  • Cof1p (COF1)
  • cofilin (TSTA_042790)
  • cofilin 1 (non-muscle) (Cfl1)
  • cofilin 1 (non-muscle)-like (LOC100341589)
  • cofilin 1, non-muscle (Cfl1)
  • COFILIN protein (COFILIN)
  • Contrafreeloading (CFL)
  • 12/8 protein
  • AA959946 protein
  • Adf protein
  • ADF/cofilin protein
  • Cadf protein
  • cb86 protein
  • CFL protein
  • CFL1 protein
  • CG4254 protein
  • Cof protein
  • cofilin protein
  • cofilin/actin depolymerizing factor homolog protein
  • cofilin/ADF protein
  • D-cof protein
  • D61 protein
  • Dmel\\CG4254 protein
  • l(2)03101 protein
  • l(2)k03101 protein
  • l(2)k05633 protein
  • l(2)k13409 protein
  • ntf protein
  • sb:cb86 protein
  • T8 protein
  • Tsr protein
  • wu:fb18a04 protein
  • wu:fk77b03 protein
  • xac1 protein
  • xac2 protein
  • zgc:56501 protein

Protein level used designations for Cofilin 1 (Non-Muscle) Proteins (CFL1)

ADF/cofilin-1 , cofilin-1-A , ADF/cofilin , cofilin-1 , non-muscle cofilin 1 , cofilin 1 (non-muscle) , ADFcofilin , CG4254-PA , Cofilin/actin depolymerizing factor-like , DCofilin , actin-depolymerizing factor , cofilin , no terminal filament , tsr-PA , twin star , Cof1p , 18 kDa phosphoprotein , cofilin, non-muscle isoform , p18

379258 Xenopus laevis
407855 Xenopus (Silurana) tropicalis
406738 Danio rerio
745772 Pan troglodytes
37841 Drosophila melanogaster
850676 Saccharomyces cerevisiae S288c
8104756 Talaromyces stipitatus ATCC 10500
1072 Homo sapiens
476022 Canis lupus familiaris
534553 Bos taurus
100732287 Cavia porcellus
494432 Ovis aries
100341589 Oryctolagus cuniculus
12631 Mus musculus
29271 Rattus norvegicus
445532 Sus scrofa
100309654 Gallus gallus
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