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Results suggest that elevation of actin dynamics by Xenopus ADF/cofilin (XAC) activation through Slingshot phosphatase (XSSH) phosphorylation is required for meiotic spindle assembly.
Gastrulation movement requires ADF/cofilin activity through dynamic regulation of its phosphorylation state.
proper actin turnover mediated by Cfl1 is essential for adhesion between the deep cell layer and the enveloping layer and cell movements during gastrulation in zebrafish
Silencing of cofilin-1 led to an Accumulation of F-actin fibers and significantly decreased podocyte migration. ability
Taken together, our data suggest that Tsr is required for cell survival and tissue growth by regulating JNK (show MAPK8 Proteins) and Yki (show YAP1 Proteins) signaling while maintaining the epithelial integrity by controlling cell junctions. This study provides an insight into potential roles of ADF/cofilin in invasive cell migration and tumor suppression in higher animals.
Mical and cofilin, therefore, form a redox-dependent synergistic pair that promotes F-actin instability by rapidly dismantling F-actin and generating post-translationally modified actin that has altered assembly properties
Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism.
AIP1 enhances cofilin-mediated actin disassembly in the apical region of precluster cells to promote remodeling of adherense junctions.
Data show that cofilin is required for F-actin turnover and lamellipodial protrusion in the border cells.
tsr is required for planar cell polarity patterning.
These results indicate that changes in the extent of cofilin phosphorylation are regulated by Ssh in response to changes in the levels and/or organisation of F-actin.
Results show that twinstar (tsr), which encodes Drosophila cofilin/ADF (actin-depolymerizing factor), is required for elongation of the retinal cell body and the morphogenesis of the rhabdomere.
Results suggest that the immune-complex (IC) of cofilin-1 in sera is a potentially attractive serum biomarker for the prognosis of pancreatic ductal adenocarcinoma (PDAC).
High cofilin expression is associated with adrenocortical tumor.
In advance urothelial cancer, overexpression of nuclear cofilin correlates with bladder cancer progression.
Report structural basis for noncanonical substrate recognition of cofilin-1/LIMK1 to regulation actin cytoskeleton dynamics.
STMN1 (show STMN1 Proteins),COF1 and PAIRBP1 (show SERBP1 Proteins) thus represent proteins associated with proliferative and aggressive tumors of high grades, while TSP2 (show THBS2 Proteins) and POSTN (show POSTN Proteins) were connected to low grade tumors with better prognosis
We observed marked increases in LIM kinase 2 (LIMK2 (show LIMK2 Proteins)) and cofilin 1 (CFL1) gene expressions in metabolic syndrome patients.
Therefore, miR (show MLXIP Proteins)-138/LIMK1 (show LIMK1 Proteins)/cofilin may be considered a potential therapeutic target for the treatment of non-small cell lung cancer
These findings indicate that inhibition of the Rac1WAVE2Arp2/3 signaling pathway may promote radiosensitivity, which may partially result from the downregulation of CFL1 (show VPS72 Proteins) in U251 human glioma cells.
The present findings demonstrated that the anticancer effect of docetaxel induces the apoptosis of prostate cancer via the suppression of the cofilin1 and paxillin (show PXN Proteins) signaling pathways, which will assist in setting a stage for the clinical treatment of prostate cancer.
VEGFA (show VEGFA Proteins) induced phosphorylation of Pak1 (show PAK1 Proteins) and its effector cofilin in a manner that was dependent on time as well as p38MAPKbeta.
Myosin phosphatase and cofilin mediate cAMP/cAMP-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin II regulatory light chain phosphorylation
Cyclic compression for 10 min up-regulated gene expression for the actin depolymerising proteins, cofilin and destrin (show DSTN Proteins).
the Rap1-cofilin-1 pathway coordinates actin and microtubule organization at the immune synapse.
Data show that the primary effect of costimulation blockade was to decrease recruitment of the activator of actin nucleation WAVE2 (Wiskott-Aldrich syndrome protein family member protein 2) and cofilin (actin-severing protein) to F-actin.
These results strongly support the active role of cofilin in ischemia-induced neuronal degeneration and apoptosis.
Caspase-11 (show CASP4 Proteins) targets cofilin via the RhoA GTPase, whereas caspase-1 (show CASP1 Proteins) engages the Slingshot phosphatase
aberrant cofilin phosphorylation that induces actin polymerization might be a consequence of actin disassembly induced by the absence of Rac1.
novel roles for actin-depolymerizing factor (show DSTN Proteins) and cofilin-1 in regulating the remodeling and permeability of epithelial junctions
reelin (show RELN Proteins) and cofilin cooperate in controlling cytoskeletal dynamics during neuronal migration.
The data of this study identify overlapping functions for ADF (show TXN Proteins) and n-cofilin in presynaptic physiology and vesicle in mice. trafficking.
Actin depolymerizing factor/cofilin double mutant mice exhibited hyperlocomotion, impulsivity, and impaired working memory. Hyperlocomotion and impulsive behavior were reversed by methylphenidate.
In vitro, formation of cofilin oligomers was drastically reduced after phosphorylation by LIMK2 (show LIMK2 Proteins).
glucose increases p-cofilin by phosphorylating LIMK1 through activation of Rho/Rho kinase, probably due to diacylglycerol-sensitive PKC activation resulting from increased glucose influx
Cofilin is necessary for maintaining the osmotic responsiveness of the cytoskeleton in tubular cells, and the Rho/ROCK/LIMK-mediated cofilin phosphorylation is a key mechanism in the hyperosmotic stress-induced F-actin increase.
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
, non-muscle cofilin 1
, cofilin 1 (non-muscle)
, Cofilin/actin depolymerizing factor-like
, actin-depolymerizing factor
, no terminal filament
, twin star
, 18 kDa phosphoprotein
, cofilin, non-muscle isoform