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anti-Human DISC1 Antibodies:
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Human Polyclonal DISC1 Primary Antibody for IHC - ABIN965998
Millar, Wilson-Annan, Anderson, Christie, Taylor, Semple, Devon, St Clair, Muir, Blackwood, Porteous: Disruption of two novel genes by a translocation co-segregating with schizophrenia. in Human molecular genetics 2000
Show all 5 Pubmed References
Human Polyclonal DISC1 Primary Antibody for ICC, ELISA - ABIN1002211
Morris, Kandpal, Ma, Austin: DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. in Human molecular genetics 2003
Show all 4 Pubmed References
Human Polyclonal DISC1 Primary Antibody for ELISA, WB - ABIN1002212
Taya, Shinoda, Tsuboi, Asaki, Nagai, Hikita, Kuroda, Kuroda, Shimizu, Hirotsune, Iwamatsu, Kaibuchi: DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Show all 4 Pubmed References
Polyclonal DISC1 Primary Antibody for IHC (p), WB - ABIN540418
Brandon, Handford, Schurov, Rain, Pelling, Duran-Jimeniz, Camargo, Oliver, Beher, Shearman, Whiting: Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. in Molecular and cellular neurosciences 2004
Show all 3 Pubmed References
Polyclonal DISC1 Primary Antibody for IHC (fro), IHC (p) - ABIN540381
Ozeki, Tomoda, Kleiderlein, Kamiya, Bord, Fujii, Okawa, Yamada, Hatten, Snyder, Ross, Sawa: Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. in Proceedings of the National Academy of Sciences of the United States of America 2003
Show all 2 Pubmed References
Human Polyclonal DISC1 Primary Antibody for ICC, IHC (fro) - ABIN258328
El-Hassar, Simen, Duque, Patel, Kaczmarek, Arnsten, Yeckel: Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels. in Biological psychiatry 2014
A Disc1 peptide binds to GSK3beta (show GSK3b Antibodies), and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin (show CTNNB1 Antibodies)-mediated Wnt (show WNT2 Antibodies) signaling and inhibiting GSK3beta (show GSK3b Antibodies) activity.
Disc1 and nrg1 (show NRG1 Antibodies) function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Antibodies)-expressing precursor cells.
Disc1 functions in the transcriptional repression of foxd3 (show FOXD3 Antibodies) and sox10 (show SOX10 Antibodies), thus mediating cranial neural crest cell migration and differentiation.
Study reports sex-specific influence of common disrupted-in-schizophrenia-1 variants on volumes of the basal ganglia, the amygdala and on the cortical surface area.
Study found a significant association between the DISC1 gene polymorphism rs6675281 alone, and the combination of rs6675281 and rs821616, and differences in long-term cortical thickness growth in patients with a first-episode of psychosis; and observed an overall difference in cortical thickness, as well as heightened disparities in the frontal and temporal brain regions.
HTT (show HTT Antibodies) forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4 (show PDE4A Antibodies)) to regulate PDE4 (show PDE4A Antibodies) activity.
This theme highlights the importance of understanding precisely how DISC1 can regulate intracellular trafficking, and suggests that a novel approach to the treatment of psychiatric disorders could be provided by targeting this protein and the trafficking machinery with which it interacts.
Findings indicate that disrupted-in-schizophrenia 1 (DISC1) and close homolog of L1 (show CHL1 Antibodies) may engage in physical and functional interaction in neural development, supporting the notion that DISC1 regulates neurite outgrowth with a receptor belonging to the neural cell adhesion molecules.
DISC1 increased the risk for late-onset Alzheimer's disease in northern Han Chinese population.
Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta (show GSK3b Antibodies) phosphorylation.
DISC1 has distinctly folded regions, which are bisected by mental illness-related mutations
These results should contribute to reveal DISC1 physiological function and potential pathogenic role in severe mental illnesses
This population-based case-control study was carried out to determine whether polymorphisms in DISC1 and NRG1 (show NRG1 Antibodies) genes could be associated with schizophrenia in the Chinese population.
Co-disruption of DISC1 and NRG1 (show NRG1 Antibodies), indicative of epistasis, evoked an impairment in sociability and enhanced self-grooming, accompanied by changes in hypothalamic oxytocin/vasopressin (show AVP Antibodies) gene expression in a mouse schizophrenia model.
the 100P mutation in Disc1 prevents expression of parvalbumin (show PVALB Antibodies) by a normally sized cohort of interneurons and altering Disc1 function in cortical excitatory neurons indirectly affects parvalbumin (show PVALB Antibodies) expression by cortical interneurons, perhaps as a result of altered functional input from the excitatory neurons.
mutant DISC1 diminished the capacity of astrocytes to support dendritic and synaptic maturation in co-cultured neurons
abnormality in hippocampal activity at the goal zone during the task may underlie the learning deficit observed in the DISC1 mutant mice.
Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta (show GSK3b Antibodies) signaling and sex-dependent behavioral effects in mice
Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.
Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Antibodies) activity via Disc1.
Results indicate that DISC1 attenuates Abeta (show APP Antibodies) generation and cognitive deficits of APP (show APP Antibodies)/PS1 (show PSEN1 Antibodies) transgenic mice through promoting lysosomal degradation of BACE1 (show BACE Antibodies)
These results suggest that alteration of CB1R (show CNR1 Antibodies)-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors.
These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
disrupted in schizophrenia 1 protein
, disrupted in schizophrenia 1
, disrupted in schizophrenia 1 homolog