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Browse our anti-DISC1 (DISC1) Antibodies

Full name:
anti-Disrupted in Schizophrenia 1 Antibodies (DISC1)
On www.antibodies-online.com are 189 Disrupted in Schizophrenia 1 (DISC1) Antibodies from 24 different suppliers available. Additionally we are shipping DISC1 Proteins (9) and DISC1 Kits (3) and many more products for this protein. A total of 213 DISC1 products are currently listed.
Synonyms:
C1orf136, DISC1, SCZD9
list all antibodies Gene Name GeneID UniProt
DISC1 27185 Q9NRI5
DISC1 244667 Q811T9
DISC1 307940 Q810H6

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anti-Rat (Rattus) DISC1 Antibodies:

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Top referenced anti-DISC1 Antibodies

  1. Human Polyclonal DISC1 Primary Antibody for EIA, IF - ABIN499748 : Morris, Kandpal, Ma, Austin: DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. in Human molecular genetics 2003 (PubMed)
    Show all 4 references for ABIN499748

  2. Human Polyclonal DISC1 Primary Antibody for FACS, IHC (p) - ABIN658716 : Park, Jeong, Lee, Mun, Kim, Lee, Nguyen, Han, Suh, Park: Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 3 references for ABIN658716

  3. Human Polyclonal DISC1 Primary Antibody for EIA, WB - ABIN492932 : Camargo, Wang, Brandon: What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology? in Novartis Foundation symposium 2008 (PubMed)
    Show all 3 references for ABIN492932

  4. Human Polyclonal DISC1 Primary Antibody for EIA, FACS - ABIN951917 : Kaibuchi, Tsuboi: [Current perspective on the pathogenesis of schizophrenia from the viewpoint of risk factors such as DISC1 (corrected)]. in Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 2010 (PubMed)
    Show all 3 references for ABIN951917

  5. Mouse (Murine) Polyclonal DISC1 Primary Antibody for ICC, IHC (fro) - ABIN258331 : El-Hassar, Simen, Duque, Patel, Kaczmarek, Arnsten, Yeckel: Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels. in Biological psychiatry 2014 (PubMed)

  6. Human Polyclonal DISC1 Primary Antibody for ELISA, WB - ABIN190904 : Millar, Pickard, Mackie, James, Christie, Buchanan, Malloy, Chubb, Huston, Baillie, Thomson, Hill, Brandon, Rain, Camargo, Whiting, Houslay, Blackwood, Muir, Porteous: DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. in Science (New York, N.Y.) 2005 (PubMed)

More Antibodies against DISC1 Interaction Partners

Zebrafish Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. A Disc1 peptide binds to GSK3beta (show GSK3b Antibodies), and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin (show CTNNB1 Antibodies)-mediated Wnt (show WNT2 Antibodies) signaling and inhibiting GSK3beta (show GSK3b Antibodies) activity.

  2. Disc1 and nrg1 (show NRG1 Antibodies) function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Antibodies)-expressing precursor cells.

  3. Disc1 functions in the transcriptional repression of foxd3 (show FOXD3 Antibodies) and sox10 (show SOX10 Antibodies), thus mediating cranial neural crest cell migration and differentiation.

Human Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. DISC1 increased the risk for late-onset Alzheimer's disease in northern Han Chinese population.

  2. Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta (show GSK3b Antibodies) phosphorylation.

  3. DISC1 has distinctly folded regions, which are bisected by mental illness-related mutations

  4. These results should contribute to reveal DISC1 physiological function and potential pathogenic role in severe mental illnesses

  5. This population-based case-control study was carried out to determine whether polymorphisms in DISC1 and NRG1 (show NRG1 Antibodies) genes could be associated with schizophrenia in the Chinese population.

  6. This study demonstrated that the Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia.

  7. The present findings, at least in part, provide some clues for further investigating the association of DISC1 variants with SCZ susceptibility

  8. DISC1 may be involved in sleep regulation

  9. Polymorphisms in DISC1 play a role in vulnerability to opioid dependence in a Polish sample.

  10. Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Antibodies) activity via DISC1.

Mouse (Murine) Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. mutant DISC1 diminished the capacity of astrocytes to support dendritic and synaptic maturation in co-cultured neurons

  2. abnormality in hippocampal activity at the goal zone during the task may underlie the learning deficit observed in the DISC1 mutant mice.

  3. Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta (show GSK3b Antibodies) signaling and sex-dependent behavioral effects in mice

  4. Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.

  5. Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Antibodies) activity via Disc1.

  6. Results indicate that DISC1 attenuates Abeta (show APP Antibodies) generation and cognitive deficits of APP (show APP Antibodies)/PS1 (show PSEN1 Antibodies) transgenic mice through promoting lysosomal degradation of BACE1 (show BACE Antibodies)

  7. These results suggest that alteration of CB1R (show CNR1 Antibodies)-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors.

  8. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.

  9. These results suggest a mechanism by which cross-talk between DISC1 and NRG1 (show NRG1 Antibodies)-ErbB4 (show ERBB4 Antibodies) signalling may contribute to these deficits.

  10. Study found that DISC1 influences APP (show APP Antibodies) C-terminal processing and Abeta (show APP Antibodies) peptide generation, affects surface expression and internalization of APP (show APP Antibodies) in neurons

DISC1 Antigen Profile

Antigen Summary

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with DISC1

  • disrupted in schizophrenia 1 (disc1) antibody
  • disrupted in schizophrenia 1 (DISC1) antibody
  • disrupted in schizophrenia 1 (Disc1) antibody
  • C1orf136 antibody
  • DISC1 antibody
  • SCZD9 antibody

Protein level used designations for DISC1

disrupted in schizophrenia 1 protein , disrupted in schizophrenia 1 , disrupted in schizophrenia 1 homolog

GENE ID SPECIES
407621 Danio rerio
719086 Macaca mulatta
742093 Pan troglodytes
100060246 Equus caballus
488970 Canis lupus familiaris
613555 Bos taurus
100156849 Sus scrofa
100356059 Oryctolagus cuniculus
100580606 Nomascus leucogenys
27185 Homo sapiens
244667 Mus musculus
307940 Rattus norvegicus
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