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Human SMURF1 Protein expressed in Wheat germ - ABIN1320726
Wang, Zhang, Weng, Qiao, Ma, Xiao, Yu, Pan, Sun et al.: Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in ... in The Journal of biological chemistry 2013
we propose that the PKA-Smurf1-PIPKIgamma pathway has an important role in pulmonary tumorigenesis and imposes substantial clinical impact on development of novel diagnostic markers and therapeutic targets for lung cancer treatment.
SMU (show MLXIP Proteins)RF1 is increased in patients with pulmonary arterial hypertension
Data suggest that SMURF1 is required for S phase progression; SMURF1 promotes ubiquitination-dependent degradation of WEE1 (show WEE1 Proteins); these functions of SMURF1 appear to be linked and may be important in cell proliferation and tumorigenesis. (SMURF1 = SMAD specific E3 ubiquitin protein ligase 1; WEE1 (show WEE1 Proteins) = wee 1 (show WEE1 Proteins) homolog [S pombe] protein)
Taken together, our study for the first time clarified that the E3 ligase Smurf1 regulates USP5 protein stability and USP5-mediated TNF-alpha production through the ubiquitin proteasome pathway.
results reveal the regulatory circuit between RUNX2 (show RUNX2 Proteins) and SMURF1 controls RUNX2 (show RUNX2 Proteins) expression and regulates odntoblastic differentiation in hDPSCs.
EGF (show EGF Proteins)/Smurf1 inhibits Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-induced osteogenic differentiation and that Smurf1 downregulates Wnt/b-catenin signaling by enhancing proteasomal degradation of beta-catenin (show CTNNB1 Proteins).
a model that CD166 (show ALCAM Proteins) regulates MCAM (show MCAM Proteins) through a signaling flow from activation of PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and c-Raf (show RAF1 Proteins)/MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) signaling to the inhibition of potential MCAM (show MCAM Proteins) ubiquitin E3 ligases, betaTrCP (show BTRC Proteins) and Smurf1.
SND1 (show SND1 Proteins) promoted expression of the E3 ubiquitin ligase Smurf1, leading to RhoA (show RHOA Proteins) ubiquitination and degradation.
NF-kappaB (show NFKB1 Proteins) bind to the -411 to -420 region of the SMURF1 promoter and plays an essential role in the expression of SMURF1.
Smurf1 determines cell apoptosis rates downstream of DNA damage-induced ATR/Chk1 signalling by promoting degradation of RhoB.
Six2 (show SIX2 Proteins) mediates the protective effects of GDNF on damaged DA neurons by regulating Smurf1 expression.
TGF-beta (show TGFB1 Proteins) inhibited osteoblastic differentiation by inducing the MAPK-ERK (show MAPK1 Proteins) pathway which upregulated the expression of ubiquitin ligase (show RNF123 Proteins) SMURF1 and resulted in reduced presence of osteogenic proteins.
demonstration that Smurf1 acts as a brake for integrin activation by controlling Kindlin-2 (show FERMT2 Proteins) protein levels, a new mechanism that permits precise modulation of integrin-mediated cellular functions
miR (show MLXIP Proteins)-140-5p and SMURF1 are key regulators of disease pathology in pulmonary arterial hypertension
Smurf1 is required for selective autophagy of Mycobacterium tuberculosis and host defense against tuberculosis infection.
Smurf1 regulates glucose metabolism and inhibits osteoblast differentiation. Smurf1 function requires the presence of serine 148 (S148) in Smurf1.
Smurf1 mediates NGF (show NGFB Proteins) signaling and ubiquitinates RhoA (show RHOA Proteins) in growth cones, regulating the need for local translation and degradation.
Smurf-mediated endocytosis of Patched1 (show PTCH1 Proteins) is required in sonic hedgehog (show SHH Proteins) signal reception
Inhibition of rhBMP-2-induced ALP (show CCL21A Proteins) activity by intracellular delivery of SMURF1 in murine calvarial preosteoblast cells.
Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 (show AXIN1 Proteins) negatively regulates Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
Data demonstrate that Smurf1 and Smurf2 (show SMURF2 Proteins) have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.
In Xenopus embryos, the BMP pathway is a major physiological target of Smurf1. We propose that in normal development Smurf1 cooperates with secreted BMP antagonists to limit BMP signaling in dorsal ectoderm.
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.
Smad ubiquitination regulatory factor 1
, E3 ubiquitin-protein ligase SMURF1
, SMAD specific E3 ubiquitin protein ligase 1
, e3 ubiquitin-protein ligase SMURF1-like
, E3 ubiquitin ligase SMURF1
, SMAD-specific E3 ubiquitin-protein ligase 1
, Smad-specific E3 ubiquitin ligase 1
, SMAD ubiquitination regulatory factor 1