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Human SMURF1 Protein expressed in Wheat germ - ABIN1320726
Wang, Zhang, Weng, Qiao, Ma, Xiao, Yu, Pan, Sun et al.: Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in ... in The Journal of biological chemistry 2013
results reveal the regulatory circuit between RUNX2 (show RUNX2 Proteins) and SMURF1 controls RUNX2 (show RUNX2 Proteins) expression and regulates odntoblastic differentiation in hDPSCs.
EGF (show EGF Proteins)/Smurf1 inhibits Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-induced osteogenic differentiation and that Smurf1 downregulates Wnt/b-catenin signaling by enhancing proteasomal degradation of beta-catenin (show CTNNB1 Proteins).
a model that CD166 (show ALCAM Proteins) regulates MCAM (show MCAM Proteins) through a signaling flow from activation of PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and c-Raf (show RAF1 Proteins)/MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) signaling to the inhibition of potential MCAM (show MCAM Proteins) ubiquitin E3 ligases, betaTrCP (show BTRC Proteins) and Smurf1.
SND1 (show SND1 Proteins) promoted expression of the E3 ubiquitin ligase Smurf1, leading to RhoA (show RHOA Proteins) ubiquitination and degradation.
NF-kappaB (show NFKB1 Proteins) bind to the -411 to -420 region of the SMURF1 promoter and plays an essential role in the expression of SMURF1.
Smurf1 determines cell apoptosis rates downstream of DNA damage-induced ATR/Chk1 signalling by promoting degradation of RhoB.
The role of SMURF1 and inhibition of BMP signaling in maintaining a CSC-like population was confirmed by the loss of a CD44 (show CD44 Proteins)(high) expressing.
Results suggest that elevated transcription and expression levels of ubiquitin ligase E3s WWP1 (show WWP1 Proteins), Smurf1 and Smurf2 (show SMURF2 Proteins) genes may be the mechanisms of occurrence, development and metastasis of prostate cancer.
Fbxo3 (show FBXO3 Proteins) promotes the proteasomal degradation of Smurf1. Fbxo3 (show FBXO3 Proteins) promotes the poly-ubiquitination of Smurf1.
TRIB2 (show TRIB2 Proteins) associated-ubiquitin E3 ligases beta-transducin repeat-containing E3 ubiquitin protein ligase (beta-TrCP (show BTRC Proteins)), COP1 (show CARD16 Proteins) and Smad ubiquitination regulatory factor 1 (Smurf1) reduced TCF4 (show TCF4 Proteins)/beta-Catenin (show CTNNB1 Proteins) expression, and these effects could be enhanced by TRIB2 (show TRIB2 Proteins).
Smurf1 regulates glucose metabolism and inhibits osteoblast differentiation. Smurf1 function requires the presence of serine 148 (S148) in Smurf1.
Smurf1 mediates NGF (show NGFB Proteins) signaling and ubiquitinates RhoA (show RHOA Proteins) in growth cones, regulating the need for local translation and degradation.
Smurf-mediated endocytosis of Patched1 (show PTCH1 Proteins) is required in sonic hedgehog (show SHH Proteins) signal reception
Inhibition of rhBMP-2-induced ALP (show CCL21A Proteins) activity by intracellular delivery of SMURF1 in murine calvarial preosteoblast cells.
Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 (show AXIN1 Proteins) negatively regulates Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
These results suggest that the JNK (show MAPK8 Proteins)/AP-1 (show JUN Proteins) and ERK (show EPHB2 Proteins)/Runx2 (show RUNX2 Proteins) signaling pathways mediate TNF-alpha (show TNF Proteins)-dependent Smurf1 transcription.
Smurf1 is a negative feedback regulator for IFN-gamma (show IFNG Proteins) signaling by targeting STAT1 (show STAT1 Proteins) for ubiquitination and proteasomal degradation.
studies uncover a cell-cycle-independent function of Cdh1 (show CDH1 Proteins), establishing Cdh1 (show CDH1 Proteins) as an upstream component that governs Smurf1 activity
ER stress induces Smurf1 degradation and WFS1 (show WFS1 Proteins) up-regulation
Smurf1 negatively regulates mesenchymal stem cell proliferation and differentiation by controlling JunB turnover through an ubiquitin-proteasome pathway.
Data demonstrate that Smurf1 and Smurf2 (show SMURF2 Proteins) have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.
In Xenopus embryos, the BMP pathway is a major physiological target of Smurf1. We propose that in normal development Smurf1 cooperates with secreted BMP antagonists to limit BMP signaling in dorsal ectoderm.
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.
Smad ubiquitination regulatory factor 1
, E3 ubiquitin-protein ligase SMURF1
, SMAD specific E3 ubiquitin protein ligase 1
, e3 ubiquitin-protein ligase SMURF1-like
, E3 ubiquitin ligase SMURF1
, SMAD-specific E3 ubiquitin-protein ligase 1
, Smad-specific E3 ubiquitin ligase 1
, SMAD ubiquitination regulatory factor 1