Browse our anti-GPSM2 (GPSM2) Antibodies

Full name:
anti-G-Protein Signaling Modulator 2 Antibodies (GPSM2)
On are 58 G-Protein Signaling Modulator 2 (GPSM2) Antibodies from 16 different suppliers available. Additionally we are shipping GPSM2 Proteins (4) and many more products for this protein. A total of 67 GPSM2 products are currently listed.
6230410J09Rik, CMCS, dfnb82, lgn, Pins, Pinsa, RGD1560967, zgc:63574
list all antibodies Gene Name GeneID UniProt
GPSM2 29899 P81274
GPSM2 362021  
GPSM2 76123 Q8VDU0

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anti-Human GPSM2 Antibodies:

anti-Rat (Rattus) GPSM2 Antibodies:

anti-Mouse (Murine) GPSM2 Antibodies:

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Top referenced anti-GPSM2 Antibodies

  1. Human Polyclonal GPSM2 Primary Antibody for ICC, IF - ABIN4315933 : Kotak, Busso, Gönczy: NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane. in The EMBO journal 2014 (PubMed)
    Show all 2 references for 4315933

  2. Cow (Bovine) Polyclonal GPSM2 Primary Antibody for IF, IHC - ABIN2784504 : Izaki, Kamakura, Kohjima, Sumimoto: Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. in Biochemical and biophysical research communications 2006 (PubMed)

  3. Human Polyclonal GPSM2 Primary Antibody for ELISA, WB - ABIN188736 : Yasumi, Sakisaka, Hoshino, Kimura, Sakamoto, Yamanaka, Ohno, Takai: Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division. in The Journal of biological chemistry 2005 (PubMed)

More Antibodies against GPSM2 Interaction Partners

Human G-Protein Signaling Modulator 2 (GPSM2) interaction partners

  1. Data support the notion that the Galpha (show SUCLG1 Antibodies), but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 (show TRPC4 Antibodies) activation and unveil new roles for RGS (show PITX2 Antibodies) and LGN in fine-tuning TRPC4 (show TRPC4 Antibodies) activities.

  2. high expression of G-protein signaling modulator 2 was involved in the pathological processes of hepatocellular carcinoma through activation of the phosphatidylinositol 3-kinase/protein kinase B (show AKT1 Antibodies) signaling pathway, which may provide an attractive potential diagnostic biomarker and therapeutic target for treatment of hepatocellular carcinoma.

  3. This mutation is predicted to abolish all four GoLoco domains in GPSM2 and this explains the bioinformatic prediction for this mutation to be functionally damaging. Full clinical and molecular accounts of the novel mutation are provided in this paper.

  4. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.

  5. This study determined the crystallographic structure of human Afadin (show MLLT4 Antibodies) in complex with LGN.

  6. results fit a model whereby LGN influences interphase microtubule dynamics in endothelial cells to regulate migration, cell adhesion, and sprout extension, and reveal a novel non-mitotic role for LGN in sprouting angiogenesis

  7. A crystal structure of Frmpd4 (show FRMPD4 Antibodies)-bound LGN in an oxidized form is also reported, although oxidation does not appear to strongly affect the interaction with Frmpd4 (show FRMPD4 Antibodies).

  8. LGN is required for mitotic spindle rotation but not orientation maintenance.

  9. Hepatocyte Par1b (show MARK2 Antibodies) defines lumen position in concert with the position of the astral microtubule anchoring complex LGN-NuMA (show NUMA1 Antibodies) to yield the distinct epithelial division phenotypes.

  10. one homozygous frameshift GPSM2 variants c.1473delG was identified in three Chudley-McCullough syndrome Dutch patients.

Mouse (Murine) G-Protein Signaling Modulator 2 (GPSM2) interaction partners

  1. LGN and Galphai participate in a long-inferred signal that originates outside the bundle to model its staircase-like architecture, a property that is essential for direction sensitivity to mechanical deflection and hearing.

  2. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.

  3. these results show a context-dependent function for LGN.

  4. support for the hitherto untested model that Par3 (show F2RL2 Antibodies)-mInsc (show INSC Antibodies) and Galphai3 (show GNAI3 Antibodies) act cooperatively to polarize LGN and promote perpendicular divisions

  5. LGN-TPR motifs are versatile and capable of recognizing multiple targets via diverse binding modes.

  6. X-ray crystallography and binding studies reveal that LGN GoLoco binding motifs are potent guanine nucleotide dissociation inhibitors.

  7. The restricted localization of NuMA (show NUMA1 Antibodies) in the lateral belt is instructive for the planar alignment of the mitotic spindle, and required for its planar maintenance.

  8. Knocking out LGN, (the G protein regulator), randomized the orientation of normally planar neuroepithelial divisions.

  9. Excessive LGN induces meiotic spindle organization defects by elongating the spindle and enhancing pole focusing, whereas depletion of LGN by RNA interference results in meiotic spindle deformation and chromosome misalignment.

GPSM2 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).

Alternative names and synonyms associated with GPSM2

  • G-protein signaling modulator 2 (GPSM2) antibody
  • G-protein signaling modulator 2 (gpsm2) antibody
  • G-protein signaling modulator 2 (Gpsm2) antibody
  • G-protein signalling modulator 2 (AGS3-like, C. elegans) (gpsm2) antibody
  • G-protein signalling modulator 2 (AGS3-like, C. elegans) (Gpsm2) antibody
  • 6230410J09Rik antibody
  • CMCS antibody
  • dfnb82 antibody
  • lgn antibody
  • Pins antibody
  • Pinsa antibody
  • RGD1560967 antibody
  • zgc:63574 antibody

Protein level used designations for GPSM2

G-protein signalling modulator 2 (AGS3-like, C. elegans) , G-protein-signaling modulator 2 , mosaic protein LGN , G-protein signaling modulator 2 (AGS3-like, C. elegans) , G-protein signaling modulator 2 (AGS3-like) , LGN protein , pins homolog (Drosophia)

100518248 Sus scrofa
29899 Homo sapiens
490127 Canis lupus familiaris
379843 Xenopus laevis
424342 Gallus gallus
513654 Bos taurus
362021 Rattus norvegicus
393410 Danio rerio
76123 Mus musculus
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