Browse our anti-Guanylate Cyclase 2D, Membrane (Retina-Specific) (GUCY2D) Antibodies

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anti-Guanylate Cyclase 2D, Membrane (Retina-Specific) Antibodies (GUCY2D)
On are 43 Guanylate Cyclase 2D, Membrane (Retina-Specific) (GUCY2D) Antibodies from 11 different suppliers available. Additionally we are shipping Guanylate Cyclase 2D, Membrane (Retina-Specific) Proteins (7) and many more products for this protein. A total of 51 Guanylate Cyclase 2D, Membrane (Retina-Specific) products are currently listed.
list all antibodies Gene Name GeneID UniProt
GUCY2D 3000 Q02846

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Top referenced anti-Guanylate Cyclase 2D, Membrane (Retina-Specific) Antibodies

  1. Human Polyclonal GUCY2D Primary Antibody for WB - ABIN493348 : Birdsall, Hulme: Biochemical studies on muscarinic acetylcholine receptors. in Journal of neurochemistry 1976 (PubMed)
    Show all 3 references for 493348

  2. Human Polyclonal GUCY2D Primary Antibody for EIA, FACS - ABIN952663 : Silva, Blanton, Parrado, Melo, Morato, Reis, Dias, Castro, Vasconcelos, Goddard, Barreto, Reis, Teixeira: Dengue hemorrhagic fever is associated with polymorphisms in JAK1. in European journal of human genetics : EJHG 2010 (PubMed)
    Show all 2 references for 952663

More Antibodies against Guanylate Cyclase 2D, Membrane (Retina-Specific) Interaction Partners

Human Guanylate Cyclase 2D, Membrane (Retina-Specific) (GUCY2D) interaction partners

  1. As other genotypes were identified, there were attempts to divide the genotypes by phenotype: GUCY2D-LCA was considered a cone-rod dystrophy, whereas other genotypes were designated as rod-cone dystrophies

  2. Sequencing of GUCY2D identified a novel missense mutation (c.2129C:T; p.Ala710Val) resulting in substitution of alanine by valine at position 710 changes the conformation of the regulatory segment within the kinase styk-domain of GC1 and causes loss of its helical structure, likely inhibiting phosphorylation of threonine residue within this segment, which is needed to activate the catalytic domain of the protein.

  3. These results identify dissociable effects of blindness upon the visual pathway. Further, the relatively intact postgeniculate white matter pathway in GUCY2D-LCA is encouraging for the prospect of recovery of visual function with gene augmentation therapy.

  4. Two novel mutations causing phenotypic LCA (show CLTA Antibodies) and Alstrom syndrome in Saudi patients from consanguineous families expand the genotypic spectrum of congenital retinal dystrophies.

  5. Data suggest that GCAP1 (guanylate cyclase activator 1A (show GUCA1A Antibodies); Mg2 (show MUC7 Antibodies)+ vs. Ca2 (show CA2 Antibodies)+) exhibits conformational changes in Ca2 (show CA2 Antibodies)+ switch helix that are important in activation of RetGC1; myristoylation of GCAP1 (show GUCA1A Antibodies) is important as well in attaining activator conformation.

  6. Gc1s/Gc1s phenotype variant of DBP (show GC Antibodies) and the unbound fraction of plasma RBP4 (show POLR2D Antibodies) may be considered as factors related with the incidence, and possibly the risk, of IR in CHC (show CLTC Antibodies) patients.

  7. Guanylate cyclase signaling pathway is down regulated in the pathogenesis of inflammatory bowel diseases.

  8. Studies indicate that mutations in retinal guanylate cylase-1 (GUCY2D) are associated with a leading cause of recessive Leber congenital amaurosis (LCA1).

  9. The GUCY2D mutations were frequent in Chinese families with autosomal dominant cone or cone-rod dystrophies. All mutations were found in exon 13.

  10. Dimerization domain of RETGC1 is an essential part of GCAP1 (show GUCA1A Antibodies) and GCAP2 (show GUCA1B Antibodies) binding interface.

Cow (Bovine) Guanylate Cyclase 2D, Membrane (Retina-Specific) (GUCY2D) interaction partners

  1. The findings define a new regulatory mechanism of the ROS-GC system that affects visual transduction and is likely to affect the course of retinal diseases caused by cGMP toxicity.

  2. The coexpression of ROS-GC1 and its activators in spermatozoa suggests that the Ca(2+)-modulated ROS-GC1 transduction system may be a part of the fertilization machinery

  3. Mg(2 (show MCOLN1 Antibodies)+) binding to GCAPs is critical for setting the actual dynamic range of RetGC regulation by GCAPs at physiological levels of free Ca(2 (show CA2 Antibodies)+)

  4. The Tyr965-Asn981 region of rod outer segment membrane guanylate cyclase type 1 (ROS-GC1) houses both the structural and functional components that mediate guanylate cyclase activating protein type 2 (GCAP2 (show GUCA1B Antibodies)) regulation.

Guanylate Cyclase 2D, Membrane (Retina-Specific) (GUCY2D) Antigen Profile

Antigen Summary

This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases.

Alternative names and synonyms associated with Guanylate Cyclase 2D, Membrane (Retina-Specific) (GUCY2D)

  • guanylate cyclase 2D, membrane (retina-specific) (GUCY2D) antibody
  • CORD5 antibody
  • CORD6 antibody
  • CYGD antibody
  • GUC1A4 antibody
  • GUC2D antibody
  • LCA antibody
  • LCA1 antibody
  • RCD2 antibody
  • retGC antibody
  • RETGC-1 antibody
  • ROS-GC1 antibody
  • ROSGC antibody

Protein level used designations for GUCY2D

ROS-GC , cone rod dystrophy 6 , guanylate cyclase 2D, retinal , retinal guanylyl cyclase 1 , rod outer segment membrane guanylate cyclase , GC-E , RETGC-1 , guanylate cyclase E

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403863 Canis lupus familiaris
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