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Expressions of REST and RCOR1 genes may downregulate SYN1 (show SYN1 Proteins) expression in gliomas.
Rcor1 knock-out monocytes exhibited extensive self-renewal associated with hematopoietic stem cell expansion.
The results suggest that LSD1 (show KDM1A Proteins)/CoREST interacts with extranucleosomal DNA when it productively engages its nucleosome substrate.
results suggest that LSD1 (show KDM1A Proteins)-CoREST functions as an ergonomic clamp (show PDZK1 Proteins) that induces the detachment of the H3 histone (show HIST1H3B Proteins) tail from the nucleosomal DNA to make it available for capture by the enzyme active site.
Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in diffuse large B-cell lymphoma patients.
Data show that miR (show MLXIP Proteins)-22 specifically interacts with the 3' UTRs of the Rcor1, Rgs2 (show RGS2 Proteins) and HDAC4 (show HDAC4 Proteins) mRNAs.
Gfi-1B p32 (show C1QBP Proteins) isoform binds to Gfi-1B target gene promoters and associates with the LSD1 (show KDM1A Proteins)-CoREST repressor complex more efficiently than the major Gfi-1B p37 (show CCNH Proteins) isoform
the H3 binding pocket is a central target site to (i) switch off LSD1 (show KDM1A Proteins) amino oxidase activity, thus H3-tail demethylation; (ii) block the competitive binding of transcription factors; and (iii) prevent chromatin anchoring to LSD1 (show KDM1A Proteins)/CoREST.
The CoREST and REST are necessary and inimical for expression of herpes simplex virus genes.
Transciption factor SNAIL1 (show SNAI1 Proteins) mimics the histone H3 (show HIST3H3 Proteins) tail and binds to the histone demethylase (show MBD2 Proteins) LSD1 (show KDM1A Proteins)-transcription co-repressor (CoREST) complex. The crystal structure of the complex is given here.
In mature erythroid cells, a strong upsurge in Rcor3 (show RCOR3 Proteins) and a sharp decline in Rcor1 (show Rcor2 Proteins) levels counteract LSD1 (show KDM1A Proteins)/Rcor1 (show Rcor2 Proteins)/2-mediated differentiation.
Rcor1 (show Rcor2 Proteins) promotes erythropoiesis by repressing hematopoietic stem cells and/or progenitor genes, as well as the genes and signaling pathways that lead to myeloid cell fate.
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).
REST corepressor 1