Browse our CADM1 Proteins (CADM1)

Full name:
Cell Adhesion Molecule 1 Proteins (CADM1)
On are 15 Cell Adhesion Molecule 1 (CADM1) Proteins from 9 different suppliers available. Additionally we are shipping CADM1 Antibodies (115) and CADM1 Kits (8) and many more products for this protein. A total of 149 CADM1 products are currently listed.
2900073G06Rik, 3100001I08Rik, AI987920, Bl2, Igsf4, Igsf4a, Necl-2, Necl2, RA175, RA175A, RA175B, RA175C, RA175N, SgIGSF, ST17, sTSLC-1, SynCam, synCAM1, Tslc1, xnecl2
list all proteins Gene Name GeneID UniProt
Rat CADM1 CADM1 445438  
CADM1 23705 Q9BY67
CADM1 54725 Q8R5M8

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CADM1 Proteins (CADM1) by Origin

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Top referenced CADM1 Proteins

  1. Human CADM1 Protein expressed in Human Cells - ABIN2004040 : Boles, Barchet, Diacovo, Cella, Colonna: The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. in Blood 2005 (PubMed)
    Show all 5 references for 2004040

  2. Human CADM1 Protein expressed in HEK-293 Cells - ABIN2180672 : Kuramochi, Fukuhara, Nobukuni, Kanbe, Maruyama, Ghosh, Pletcher, Isomura, Onizuka, Kitamura, Sekiya, Reeves, Murakami: TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. in Nature genetics 2001 (PubMed)
    Show all 5 references for 2180672

  3. Human CADM1 Protein expressed in Wheat germ - ABIN1347851 : Hasstedt, Bezemer, Callas, Vossen, Trotman, Hebbel, Demers, Rosendaal, Bovill: Cell adhesion molecule 1: a novel risk factor for venous thrombosis. in Blood 2009 (PubMed)

More Proteins for CADM1 Interaction Partners

Human Cell Adhesion Molecule 1 (CADM1) interaction partners

  1. CADM1 mRNA expression was highly upregulated in normal tissues compared to esophageal squamous cell carcinoma tissues, indicating that the loss of CADM1 expression influenced the pathogenesis, invasion, and metastasis of ESCC.

  2. Eight and five of the nine samples were negative for cell adhesion molecule 1 and Osterix (show SP7 Proteins) respectively. The other markers showed no statistical significance(CD151 (show CD151 Proteins),ALP (show ALP Proteins)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 could be a useful marker for identifying this phenomenon in carcinoma tissues

  3. Our results suggest that, as in the CNS, CADM1 interactions drive exocytic site assembly and promote actin network formation. These results support the broader hypothesis that the effects of cell-cell contact on beta-cell maturation and function are mediated by the same extracellular protein interactions that drive the formation of the presynaptic exocytic machinery. These interactions may be therapeutic targets for re...

  4. High expression of CADM1 on most HTLV-1-infected cells in the face of enhanced cytotoxic T lymphocyte counterselection implies that CADM1 confers a strong benefit on the virus.

  5. Decreased expression of TSLC1 is associated with the differentiation in ovarian epithelial cancer. TSLC1 might be used as a molecular marker of severity in early stage ovarian cancer, and to help differentiating benign and malignant ovarian tumors.

  6. Suppression of tumorigenesis by CADM1 may be mediated by the Rb-E2F1 (show E2F1 Proteins) pathway.

  7. CADM1 prevents squamous cell carcinoma progression by reducing STAT3 (show STAT3 Proteins) activity

  8. Decreased expression of TSLC1 is correlated with the malignancy of non-muscle invasive bladder cancer tissues and low TSLC1 expression may serve as a predictor for bladder cancer recurrence and progression.

  9. CADM1 deletion is associated with neuroblastoma (show ARHGEF16 Proteins) and ganglioneuroma.

  10. Hypermethylation of CADM1 gene may be highly associated with the development of cervical cancer.

Mouse (Murine) Cell Adhesion Molecule 1 (CADM1) interaction partners

  1. The results of this study demonstrate that the synapse-organizing adhesion molecule (show NCAM1 Proteins) SynCAM 1 has pronounced effects on neuronal connectivity in the hippocampal CA3 (show CA3 Proteins) area.

  2. Cadm1 is a direct target of NFATc1 (show NFATC1 Proteins), which is induced by RANKL (show TNFSF11 Proteins) through epigenetic modification, and regulates osteoclastic bone resorption in a negative feedback manner.

  3. Data show that cell adhesion molecule 1 (SynCAM 1) generally prolongs the lifetime of spines.

  4. This experiments show that the survival rate of adult-generated neurons is increased by overexpressing SynCAM 1

  5. Our study reveals a novel mechanism of chronic NF-kappaB (show NFKB1 Proteins) activation by CADM1 in HTLV-1 infected cells

  6. Study demonstrates that polysialic acid-SynCAM 1 defines a subpopulation of NG2 (show Vcan Proteins) cells and identifies the presence of polysialic acid-NRP2 (show NRP2 Proteins) in microglia

  7. CADM1 appeared to sustain gap junctional intercellular communication among alpha-cells via homophilic binding and, based on this action, CADM1 appears to prevent excessive secretion of glucagon (show GCG Proteins) from alpha-cells.

  8. This study demonistrated that SynCAM 1 in the synaptic organization of the rod visual pathway and provide evidence for novel roles of synaptic adhesion in the structural and functional integrity of ribbon synapses.

  9. Necl-2 co-localizes with ErbB4 (show ERBB4 Proteins) in hippocampus and and regulates ErbB4 (show ERBB4 Proteins) signaling in cultured neurons.

  10. TGF-beta1 is a potent cytokine that provides an effective mechanism in controlling Necl-2 expression in the testis via Smad-dependent gene repression and clathrin-mediated endocytosis.

CADM1 Protein Profile

Protein Summary

Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Alternative names and synonyms associated with CADM1

  • cell adhesion molecule 1 (CADM1)
  • cell adhesion molecule 1 (LOC100354915)
  • immunoglobulin superfamily, member 4 (IGSF4)
  • cell adhesion molecule 1 (cadm1)
  • cell adhesion molecule 1 (Cadm1)
  • 2900073G06Rik protein
  • 3100001I08Rik protein
  • AI987920 protein
  • Bl2 protein
  • Igsf4 protein
  • Igsf4a protein
  • Necl-2 protein
  • Necl2 protein
  • RA175 protein
  • RA175A protein
  • RA175B protein
  • RA175C protein
  • RA175N protein
  • SgIGSF protein
  • ST17 protein
  • sTSLC-1 protein
  • SynCam protein
  • synCAM1 protein
  • Tslc1 protein
  • xnecl2 protein

Protein level used designations for CADM1

immunoglobulin superfamily, member 4 , cell adhesion molecule 1 , TSLC-1 , TSLC1/Nectin-like 2/IGSF4 , immunoglobulin superfamily member 4 , immunoglobulin superfamily, member 4D variant 1 , immunoglobulin superfamily, member 4D variant 2 , nectin-like 2 , nectin-like protein 2 , spermatogenic immunoglobulin superfamily , synaptic cell adhesion molecule , truncated CADM1 protein , tumor suppressor in lung cancer 1 , NECL-2 , cell adhesion molecule 1 transcript variant 8abc , immunoglobulin superfamily member 4A , immunosuperfamily protein Bl2 , immunoglobulin superfamily, member 4A , secretory isoform of TSLC1

529873 Bos taurus
100354915 Oryctolagus cuniculus
445438 Rattus norvegicus
735231 Xenopus laevis
23705 Homo sapiens
54725 Mus musculus
363058 Rattus norvegicus
479432 Canis lupus familiaris
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