CADM1 Protein (Fc Tag)

Catalog No. ABIN7320714

Product Details

Target: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This CADM1 protein is labelled with Fc Tag.

Purpose: Recombinant Mouse SynCam/CADM1 Protein (Fc Tag)(Active)

Sequence: Gln48-His388

Characteristics: Recombinant Mouse Cell adhesion molecule 1 is produced by our Mammalian expression system and the target gene encoding Gln48-His388 is expressed with a Fc tag at the C-terminus.

Purity: > 90 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Human CADM1-Fc at 2μg/ml(100 μl/well) can bind Human CRTAMV-His(Cat: PKSH032286). The ED50 of Human SCRTAMV-His(Cat: PKSH032286) is 4.905 ug/ml .

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Alternative Name: SynCam/CADM1 (CADM1 Products)

Synonyms: BL2 Protein, IGSF4 Protein, IGSF4A Protein, NECL2 Protein, Necl-2 Protein, RA175 Protein, ST17 Protein, SYNCAM Protein, TSLC1 Protein, sTSLC-1 Protein, sgIGSF Protein, synCAM1 Protein, bl2 Protein, igsf4 Protein, igsf4a Protein, necl-2 Protein, necl2 Protein, ra175 Protein, sgigsf Protein, st17 Protein, stslc-1 Protein, syncam Protein, syncam1 Protein, tslc1 Protein, xnecl2 Protein, 2900073G06Rik Protein, 3100001I08Rik Protein, AI987920 Protein, Bl2 Protein, Igsf4 Protein, Igsf4a Protein, Necl2 Protein, RA175A Protein, RA175B Protein, RA175C Protein, RA175N Protein, SgIGSF Protein, SynCam Protein, Tslc1 Protein, SynCAM1 Protein, cell adhesion molecule 1 Protein, cell adhesion molecule 1 L homeolog Protein, CADM1 Protein, cadm1.L Protein, Cadm1 Protein

Background:

Background: Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. CADM1 may contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, it may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. The protein acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. It may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Synonym: Cell adhesion molecule 1,Immunoglobulin superfamily member 4,IgSF4,Nectin-like protein 2,NECL-2,Synaptic cell adhesion molecule,SynCAM,Tumor suppressor in lung cancer 1,TSLC-1

Molecular Weight: 65.3 kDa

NCBI Accession: NP_061240

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation