Browse our Core-Binding Factor, beta Subunit Proteins (CBFB)

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Core-Binding Factor, beta Subunit Proteins (CBFB)
On www.antibodies-online.com are 13 Core-Binding Factor, beta Subunit (CBFB) Proteins from 7 different suppliers available. Additionally we are shipping Core-Binding Factor, beta Subunit Antibodies (92) and many more products for this protein. A total of 113 Core-Binding Factor, beta Subunit products are currently listed.
Synonyms:
AI893578, CBF-B, cbf-beta, Cbfb, cbfbeta, Nfya, PEA2, pea2-beta, Pebp2, pebp2-beta, PEBP2B, Pebpb2, unp1266
list all proteins Gene Name GeneID UniProt
Rat CBFB CBFB 361391  
CBFB 12400 Q08024
CBFB 865 Q13951

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Core-Binding Factor, beta Subunit Proteins (CBFB) by Origin

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Top referenced Core-Binding Factor, beta Subunit Proteins

  1. Human CBFB Protein expressed in Escherichia coli (E. coli) - ABIN2006272 : Chen, Lucey, Phoenix, Lopez-Garcia, Hart, Losson, Buluwela, Coombes, Chambon, Schär, Ali: T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for 2006272

  2. Human CBFB Protein expressed in Escherichia coli (E. coli) - ABIN667177 : Wee, Voon, Bae, Ito: PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis. in Blood 2008 (PubMed)
    Show all 2 references for 667177

More Proteins for Core-Binding Factor, beta Subunit Interaction Partners

Rhesus Monkey Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. Vif (show BTG1 Proteins) proteins of human and simian immunodeficiency viruses require cellular CBFbeta to degrade APOBEC3G (show APOBEC3G Proteins).

  2. simian immunodeficiency virus (SIV) Vif (show BTG1 Proteins) binds to and requires CBF-beta to degrade rhesus macaque APOBEC3G (show APOBEC3G Proteins)

Mouse (Murine) Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. High CBFB expression is associated with leukemia.

  2. Vif (show BTG1 Proteins) stabilization by CBFbeta is mainly caused by impairing MDM2 (show MDM2 Proteins)-mediated degradation.

  3. the mechanistic view that the proliferative function of Crlz-1 (show UTP3 Proteins) is caused by relaying Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) to pre-B cell receptor signaling pathways through the regulation of Runx/CBFbeta heterodimerization was verified

  4. Core binding factor beta deficiency in chondrocytes caused a decrease of protein levels of Runx transcription factors by accelerating polyubiquitination-mediated proteosomal degradation in vitro

  5. Cbfb plays an important role in the stabilization of Runx family proteins; and that Runx2 (show RUNX2 Proteins) protein stability is less dependent on Cbfb in calvariae than in cartilaginous limb skeletons

  6. findings indicate that Cbfbeta stabilizes Runx2 (show RUNX2 Proteins) in osteoblasts by forming a complex and thus facilitates the proper maintenance of bone mass, particularly cortical bone

  7. Runx/Cbfb signaling regulate androgen receptor (show AR Proteins) pathway, but does not affect the circulating testosterone levels or the enzymatic conversion to DHT.

  8. Cbfb deficiency results in differentiation blocks and stem cell expansion in hematopoiesis.

  9. Cbfbeta functions in upregulating Ihh (show IHH Proteins) expression to promoter chondrocyte proliferation and osteoblast differentiation, and inhibiting PPR (show PTH1R Proteins) expression to enhance chondrocyte differentiation.

  10. results demonstrate that Cbfbeta mediates cartilage and bone development by interacting with Runx1 (show RUNX1 Proteins) and Runx2 (show RUNX2 Proteins) to regulate the expressions of Col (show HDAC1 Proteins) X and Osx (show SP7 Proteins) for chondrocyte and osteoblast development

Zebrafish Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. characterization of cbfbeta gene

  2. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  3. Data demonstrate for the first time an essential role of JunB (show JUNB Proteins)-CBFbeta signaling for maintaining sarcomere architecture and function.

Human Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. The co-existence of BCR (show BCR Proteins)-ABL1 (show ABL1 Proteins) and CBFB rearrangement is associated with poor outcome and a clinical course similar to that of CML (show BCR Proteins)-BP, and unlike de novo AML (show RUNX1 Proteins) with CBFB rearrangement, suggesting that high-intensity chemotherapy with TKI should be considered in these patients.

  2. Moreover, using a CBF-beta loss-of-function mutant, the authors demonstrated that the interaction between CBF-beta and Vif (show BTG1 Proteins) was not sufficient for Vif (show BTG1 Proteins) assistance; a region including F68 in CBF-beta was also required for the stability and function of Vif (show BTG1 Proteins).

  3. Vif (show BTG1 Proteins) stabilization by CBFbeta is mainly caused by impairing MDM2 (show MDM2 Proteins)-mediated degradation.

  4. Mutational analysis of CBFbeta revealed that F68 and I55 (show FBXL14 Proteins) residues are important and participate in a tripartite hydrophobic interaction with W5 of Vif (show BTG1 Proteins) to maintain a stable and functional Vif (show BTG1 Proteins)-CBFbeta complex.

  5. Thus, an NGF (show NGFB Proteins)/TrkA (show NTRK1 Proteins)-MAPK (show MAPK1 Proteins)-CBFbeta pathway converges with Islet1 (show ISL1 Proteins)-Runx1 (show RUNX1 Proteins) signaling to promote Runx1 (show RUNX1 Proteins)/CBFbeta holocomplex formation and nonpeptidergic nociceptor maturation.

  6. Our findings demonstrate that HSPCs exposed to non-cytotoxic levels of environmental chemicals and chemotherapeutic agents are prone to topoisomerase II (show TOP2 Proteins)-mediated DNA damage at the leukemia-associated genes MLL (show MLL Proteins) and CBFB.

  7. These results provide important information on the assembly of the Vif (show BTG1 Proteins)-CUL5 (show CUL5 Proteins)-E3 ubiquitin ligase (show MUL1 Proteins) and identify a new viV binding interface with CBF-beta at the C-terminus of HIV-1 Vif (show BTG1 Proteins).

  8. CBF-beta promoted steady-state levels of HIV-1 Vif (show BTG1 Proteins) by inhibiting the degradation of HIV-1 Vif (show BTG1 Proteins) through the proteasome pathway.

  9. CBFB contributes to the transcriptional regulation of ribosomal gene expression and provide further understanding of the epigenetic role of CBFB-SMMHC (show MYH11 Proteins) in proliferation and maintenance of the leukemic phenotype.

  10. we report a novel hypomethylation pattern, specific to CBFB-MYH11 fusion resulting from inv(16) rearrangement in acute myeloid leukemia the expression of which correlated with PBX3 differential methylation

Core-Binding Factor, beta Subunit (CBFB) Protein Profile

Protein Summary

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit\; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16

Alternative names and synonyms associated with Core-Binding Factor, beta Subunit (CBFB)

  • core-binding factor, beta subunit (Cbfb)
  • core-binding factor, beta subunit (CBFB)
  • core-binding factor, beta subunit (LOC100230400)
  • core-binding factor, beta subunit (cbfb)
  • core binding factor beta subunit (Cbfb)
  • core-binding factor, beta subunit (LOC100340362)
  • core-binding factor, beta subunit (LOC100359284)
  • core binding factor beta (Cbfb)
  • nuclear transcription factor-Y alpha (Nfya)
  • nuclear transcription factor-Y beta (Nfyb)
  • AI893578 protein
  • CBF-B protein
  • cbf-beta protein
  • Cbfb protein
  • cbfbeta protein
  • Nfya protein
  • PEA2 protein
  • pea2-beta protein
  • Pebp2 protein
  • pebp2-beta protein
  • PEBP2B protein
  • Pebpb2 protein
  • unp1266 protein

Protein level used designations for CBFB

core binding factor beta , core-binding factor subunit beta , core-binding factor, beta subunit , core binding factor beta subunit , CBF-beta , PEA2-beta , PEBP2-beta , SL3-3 enhancer factor 1 subunit beta , SL3/AKV core-binding factor beta subunit , polyomavirus enhancer-binding protein 2 beta subunit , CCAAT-binding transcription factor subunit B , core-binding factor beta , SL3-3 enhancer factor 1 beta subunit , polyomavirus enhancer binding protein 2, beta subunit , CAAT box DNA-binding protein subunit A , CAAT-box DNA-binding protein subunit A , CBF-B , NF-YA , nuclear transcription factor Y subunit A , nuclear transcription factor Y subunit alpha , CAAT box DNA-binding protein subunit B , CAAT-box DNA-binding protein subunit B , CBF-A , CCAAT binding transcription factor of CBF-B/NFY-B , CCAAT-binding transcription factor subunit A , NF-YB , nuclear transcription factor - Y beta , nuclear transcription factor Y subunit B , nuclear transcription factor Y subunit beta

GENE ID SPECIES
361391 Rattus norvegicus
695767 Macaca mulatta
100230400 Taeniopygia guttata
100270773 Xenopus (Silurana) tropicalis
100313579 Saccoglossus kowalevskii
100340362 Oryctolagus cuniculus
100359284 Oryctolagus cuniculus
12400 Mus musculus
30744 Danio rerio
446882 Xenopus laevis
395257 Gallus gallus
865 Homo sapiens
479690 Canis lupus familiaris
614678 Bos taurus
29508 Rattus norvegicus
25336 Rattus norvegicus
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