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CBFB Products

(Core-Binding Factor, beta Subunit (CBFB))

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The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit\; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured CBFB Categories

CBFB Antibodies

High quality antibodies with extensive validation data.

CBFB Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CBFB Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7444325
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IF, IHC (p), FACS
Validations
  • (5)
Cat. No. ABIN390892
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (4)
Cat. No. ABIN6257985
Quantity 100 μL
Datasheet Datasheet

Recommended CBFB ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6951394
Quantity 96 tests
Datasheet Datasheet

Recommended CBFB Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348164
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348166
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7417792
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our CBFB products

Ebel, Kansas: "Functions of Smad Transcription Factors in TGF-β1-Induced Selectin Ligand Expression on Murine CD4 Th Cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 7, pp. 2627-34, (2016) (PubMed).

Synonyms and alternative names related to CBFB

core-binding factor beta subunit (CBFB), core binding factor beta subunit (Cbfb), core-binding factor, beta subunit (cbfb), core-binding factor, beta subunit (Cbfb), core-binding factor, beta subunit S homeolog (cbfb.S), core binding factor beta (Cbfb), core-binding factor beta subunit (Cbfb), AI893578, cbf-beta, Cbfb, CBFB, cbfbeta, PEA2, pea2-beta, Pebp2, pebp2-beta, PEBP2B, pebp2b, PEBP2b, Pebpb2, unp1266

Protein level used designations for CBFB

  • CBF-beta
  • PEA2-beta
  • PEBP2-beta
  • SL3-3 enhancer factor 1 beta subunit
  • SL3-3 enhancer factor 1 subunit beta
  • SL3/AKV core-binding factor beta subunit
  • core-binding factor subunit beta
  • polyomavirus enhancer binding protein 2, beta subunit
  • polyomavirus enhancer-binding protein 2 beta subunit
  • core binding factor beta subunit
  • core-binding factor, beta subunit
  • core binding factor beta
  • core-binding factor beta
  • CCAAT-binding transcription factor subunit B
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