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Browse our CTGF Proteins (CTGF)

Full name:
Connective Tissue Growth Factor Proteins (CTGF)
On are 73 Connective Tissue Growth Factor (CTGF) Proteins from 16 different suppliers available. Additionally we are shipping CTGF Antibodies (225) and CTGF Kits (80) and many more products for this protein. A total of 384 CTGF products are currently listed.
CCN2, ccn5, ct58, CTGF, ctgf-l, CTGRP, fisp-12, Fisp12, HCS24, hm:zeh1559, IGFBP8, NOV2, si:ch211-173b8.2, si:dkey-266k12.4, wu:fl25c03, XCTGF, zeh1559, zgc:136644
list all proteins Gene Name GeneID UniProt
CTGF 14219 P29268
CTGF 1490 P29279
CTGF 64032 Q9R1E9

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CTGF Proteins (CTGF) by Origin

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Top referenced CTGF Proteins

  1. Human CTGF Protein expressed in Escherichia coli (E. coli) - ABIN1046858 : Bradham, Igarashi, Potter, Grotendorst: Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. in The Journal of cell biology 1991 (PubMed)
    Show all 2 references for ABIN1046858

More Proteins for CTGF Interaction Partners

Rhesus Monkey Connective Tissue Growth Factor (CTGF) interaction partners

  1. These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.

Zebrafish Connective Tissue Growth Factor (CTGF) interaction partners

  1. this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.

  2. CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development

Mouse (Murine) Connective Tissue Growth Factor (CTGF) interaction partners

  1. This is the first time a role for CTGF in beta-cell function has been reported

  2. Overexpression of CTGF in cardiomyocytes attenuates left ventricular hypertrophy in angiotensin II induced hypertension.

  3. beta-catenin (show CTNNB1 Proteins) signaling inhibition protects against CTGF-induced alveolar and vascular pathology in neonatal mouse lung

  4. CTGF and beta-catenin (show CTNNB1 Proteins) are involved in the epithelial-mesenchymal transition of podocytes in diabetes. CTGF mediates high-glucose induced EMT (show ITK Proteins) through activation of beta-catenin (show CTNNB1 Proteins) in podocytes.

  5. CTGF is overexpressed in gastric cancer and adjacent tissue compared to normal gastric tissue. Gastrin (show GAST Proteins) induces expression of CTGF in gastric epithelial cells.

  6. These results indicate that tensile force induces in vivo gene expression associated with vascularization early in tensile-force-induced sutural bone formation. Moreover, the early induction of Vegf (show VEGFA Proteins) gene expression is regulated by CTGF and ROCK2 (show ROCK2 Proteins).

  7. these results suggested that loss of miR (show MLXIP Proteins)-30c may contribute to the pathogenesis of diabetic nephropathy (DN) by inhibiting target CTGF expression; replenishing miR (show MLXIP Proteins)-30c may ameliorate renal structure and function by reducing renal fibrosis in DN.

  8. Data suggest that PTEN phosphatase (PTEN) regulates renal extracellular matrix production via activated protein kinase B (Akt (show AKT1 Proteins)) and increased connective tissue growth factor (CTGF) in diabetes mellitus.

  9. Under physiological conditions, CCN2 may be regulating the levels of free amino acids in the extracellular matrix of cartilage.

  10. These data indicate that LPA increases CCN2 expression through the activation of PKC and PKA. Thus, the regulatory functions of the PKC and PKA pathways are implicated in the LPA-induced increase in CCN2 expression

Human Connective Tissue Growth Factor (CTGF) interaction partners

  1. Data show that the expression of Interleukin-8 (IL-8 (show IL8 Proteins)) and connective tissue growth factor (CTGF) was significantly reduced by treatment with vemurafenib and trametinib in (V600E)BRAF (show BRAF Proteins) protein melanoma cells.

  2. CTGF is overexpressed in gastric cancer and adjacent tissue compared to normal gastric tissue. Gastrin (show GAST Proteins) induces expression of CTGF in gastric epithelial cells.

  3. We found significantly more positively expressed Connective Tissue Growth Factor protein in Esophageal Squamous Cell Carcinoma tissues was than in normal adjacent esophageal tissues. MiR (show MLXIP Proteins)-145 inhibited the proliferation, migration, invasiveness, and the EMT (show ITK Proteins) process of Esophageal Squamous Cell Carcinoma cells through targeted regulation of Connective Tissue Growth Factor expression.

  4. The expression of inflammatory markers in the conjunctiva of trachomatous trichiasis patients were studied; CTGF, S100A7 (show S100A7 Proteins), and IL-1beta (show IL1B Proteins) were all increased.

  5. Study shows the role of the CTGF gene as a target of miR (show MLXIP Proteins)-18a, and identifies the function of HBV/HBX/miR (show MLXIP Proteins)-18a/CTGF as a key signaling pathway mediating HBV infection-induced HCC (show FAM126A Proteins).

  6. CTGF expression is significantly upregulated in human masticatory mucosa during wound healing

  7. TGF-beta1 (show TGFB1 Proteins), in association with the increased expression of CTGF, contribute to the homeostasis of the extracellular matrix and to the hypertrophy of ligamentum flavum through the p38 MAPK (show MAPK14 Proteins) pathway.

  8. The present study aimed to examine the clinical relevance of NOV along with CYR61 and CTGF in gastric cancer by analysing their transcript levels...the expression of NOV and CYR61 was increased in gastric cancer. The elevated expression of CYR61 was associated with poorer survival. NOV promoted proliferation and invasion of gastric cancer cells

  9. Authors found that CTGF is always associated with haemosiderin-pigmented macrophage-like cells, which suggests that CTGF is produced by synovial A cells following the uptake of blood breakdown products.

  10. Decreased expression of CTGF is a common feature in Non Small Cell Lung Cancer; however, it can be restored by the chromatin-modifying agents such as 5-dAzaC or TSA (show PRDX2 Proteins) and consequently restrain cancer development.

Pig (Porcine) Connective Tissue Growth Factor (CTGF) interaction partners

  1. CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.

  2. Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.

  3. CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.

  4. CTGF level was not altered in model of obliterative bronchiolitis.

Cow (Bovine) Connective Tissue Growth Factor (CTGF) interaction partners

  1. The results indicate that CTGF suppresses the synthesis of biglycan (show BGN Proteins) but newly induced that of decorin (show DCN Proteins) in the cells when the cell density is low.

  2. Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability

Rabbit Connective Tissue Growth Factor (CTGF) interaction partners

  1. A significant increase in TGF-beta1 (show TGFB1 Proteins) and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.

  2. Stretch is an important primary trigger for CTGF-induction in the overloaded heart.

  3. Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.

  4. TGF-beta1 (show TGFB1 Proteins) can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.

  5. Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.

Xenopus laevis Connective Tissue Growth Factor (CTGF) interaction partners

  1. Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2 (show SOX2 Proteins)-, GFAP (show GFAP Proteins)-and GFAP (show GFAP Proteins)/Nestin (show NES Proteins)-positive cells, activated p44 (show GTF2H2 Proteins)/42 signaling, and upregulated fibronectin (show FN1 Proteins). In human glioma cells, it induced GFAP (show GFAP Proteins) and nestin (show NES Proteins).

  2. Data show that connective-tissue growth factor regulates signalling through the Wnt (show WNT2 Proteins) pathway, in accord with its ability to bind to the Wnt (show WNT2 Proteins) co-receptor LDL receptor (show LDLR Proteins)-related protein 6 (LRP6 (show LRP6 Proteins)).

CTGF Protein Profile

Protein Summary

The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.

Alternative names and synonyms associated with CTGF

  • WNT1 inducible signaling pathway protein 2 (wisp2)
  • connective tissue growth factor (ctgf)
  • connective tissue growth factor (CTGF)
  • connective tissue growth factor b (ctgfb)
  • Connective tissue growth factor (ctgf)
  • connective tissue growth factor (Ctgf)
  • connective tissue growth factor (CCN2)
  • connective tissue growth factor a (ctgfa)
  • connective tissue growth factor-like (LOC476202)
  • CCN2 protein
  • ccn5 protein
  • ct58 protein
  • CTGF protein
  • ctgf-l protein
  • CTGRP protein
  • fisp-12 protein
  • Fisp12 protein
  • HCS24 protein
  • hm:zeh1559 protein
  • IGFBP8 protein
  • NOV2 protein
  • si:ch211-173b8.2 protein
  • si:dkey-266k12.4 protein
  • wu:fl25c03 protein
  • XCTGF protein
  • zeh1559 protein
  • zgc:136644 protein

Protein level used designations for CTGF

WNT1 inducible signaling pathway protein 2 , connective tissue growth factor , zCTGF-c19 , Connective tissue growth factor , connective tissue growth factor-like , CCN family member 2 , Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24) , fibroblast inducible secreated protein , fibroblast inducible secreted protein , hypertrophic chondrocyte-specific gene product 24 , hypertrophic chondrocyte-specific protein 24 , IBP-8 , IGF-binding protein 8 , IGFBP-8 , insulin-like growth factor-binding protein 8 , connective tissue growth-related protein , connective tissue growth factor XCTGF , zCTGF-c20

496678 Xenopus (Silurana) tropicalis
548598 Xenopus (Silurana) tropicalis
714520 Macaca mulatta
100124530 Danio rerio
100137400 Papio anubis
100194970 Salmo salar
100437145 Pongo abelii
100604830 Nomascus leucogenys
14219 Mus musculus
1490 Homo sapiens
64032 Rattus norvegicus
374135 Gallus gallus
100152141 Sus scrofa
281103 Bos taurus
100303607 Ovis aries
100008638 Oryctolagus cuniculus
100726380 Cavia porcellus
398003 Xenopus laevis
463003 Pan troglodytes
321449 Danio rerio
476202 Canis lupus familiaris
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