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The Tim-3/Gal-9 (show LGALS9 ELISA Kits) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
Tim3/Gal-9 (show LGALS9 ELISA Kits) alleviates the inflammation of TAO patients via suppressing Akt (show AKT1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) signaling pathway.
this study shows that severe aplastic anemia untreated patients have lower TIM-3 expression on NK cells and CD56dim NK subsets compared with normal controls, and are correlated with the severity of pancytopenia of SAA (show SAA1 ELISA Kits)
We conclude that Tim-3 is a biomarker of dysfunctional plasmacytoid dendritic cells
The present study defines the minimal TIM-3 promoter region and demonstrates its interaction with c-Jun (show JUN ELISA Kits) during TIM-3 transcription in CD4 (show CD4 ELISA Kits)(+) T cells.
Our findings establish intratumoral Tim-3(+)PD1 (show PDCD1 ELISA Kits)(+)CD8 (show CD8A ELISA Kits)(+) T cells as critical mediators of an aggressive phenotype in RCC (show XRCC1 ELISA Kits).
Osteosarcoma patients with higher Tim-3 had relatively lower survival. Multivariate analyses for overall survival revealed that high serum soluble Tim-3 level was an independent prognostic factor for osteosarcoma
urther analyses revealed that the levels of Tim-3 on CD4 (show CD4 ELISA Kits)+ T cells and CD8 (show CD8A ELISA Kits)+ T cells exhibited different expression patterns in terms of localization depending on pathological category of prostate cancer and metastasis. Immunohistochemical analysis revealed that positive staining of Tim-3 in prostate cancer but little or no staining of Tim-3 was observed in benign prostate hyperplasia epithelium.
this review discusses the recent findings on Tim-3, the role it plays in regulating immune responses in different cell types and the rationale for targeting Tim-3 for effective cancer immunotherapy
The -1516G > T, -574G > T and +4259T > G SNPs within TIM-3 gene might play an important role as a genetic risk factor in the pathogenesis of ET.
this study shows that that Tim-3 expression defines a subpopulation of PD-1 (show PDCD1 ELISA Kits)+ exhausted NY-ESO-1 (show CTAG1B ELISA Kits)-specific CD8 (show CD8A ELISA Kits)+ T cell and PD-1 (show PDCD1 ELISA Kits)+Tim-3+ CD8 (show CD8A ELISA Kits)+ T cells represented the largest subset of NY-ESO-1 (show CTAG1B ELISA Kits)-specific CD8 (show CD8A ELISA Kits)+ T cells in gastric cancer patients
demonstrated that both IL-10 (show IL10 ELISA Kits) and TGF-beta (show TGFB1 ELISA Kits) upregulated TIM-3 surface expression on dendritic cells via a common signaling pathway that involved sequential activation of c-Src (show SRC ELISA Kits) and Bruton's tyrosine kinase (show BTK ELISA Kits)
Methylation level of the TIM-3 promoter gradually decreased after each round of T-cell polarization, and this decrease was inversely correlated with TIM-3 expression.
in mice, TIM-3 is not essential for development of HDM (show HDAC3 ELISA Kits)-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM (show HDAC3 ELISA Kits)-induced chronic allergic airway inflammation.
Authors found that a CD8 (show CD8A ELISA Kits)(+) T-cell population with age-associated exhaustion was distinguishable by its expression of Tim-3.
TIM4 (show TIMD4 ELISA Kits) binds TIM3 on the surface of polarized Th1 (show HAND1 ELISA Kits) cells to induce Th1 (show HAND1 ELISA Kits) cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.
The Gal-9 (show LGALS9 ELISA Kits)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.
TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.
Tim-3 acts at a receptor-proximal point to enhance Lyn (show LYN ELISA Kits) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (show FCER1A ELISA Kits) ligation.
Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer
TIM-3 plays a role in regulating the uterine natural killer cells and contributes to the maintenance of tolerance at the feto-maternal interface.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
hepatitis A virus cellular receptor 2
, T cell immunoglobulin mucin 3
, T cell immunoglobulin mucin-3
, T-cell immunoglobulin and mucin domain-containing protein 3
, T-cell membrane protein 3
, kidney injury molecule-3
, T-cell immunoglobulin and mucin domain containing 3
, hepatitis A virus cellular receptor 2 homolog