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The Tim-3/Gal-9 (show LGALS9 ELISA Kits) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
Results indicate that T cell Ig and mucin domain 3 protein (TIM-3) polymorphisms (-1516G/T, -574G/T, and +4259T/G) were associated with the increased risk of cancer in Chinese Han population.
In cultured MART1 (show MLANA ELISA Kits)-specific CD8 (show CD8A ELISA Kits) T cells stimulated with peptide-loaded artificial antigen-presenting cells, anti-TIM-3 antibody treatment promotes generation of effector T cells, with acquisition of an activated phenotype, increased cytokine production, enhanced proliferation, and a transcription program associated with T cell differentiation. Anti-TIM-3 drives CD8 (show CD8A ELISA Kits) T cell differentiation through activation of mTORC1.
Our results show that Tim-3 is a critical negative regulator of NLRP3 (show NLRP3 ELISA Kits) inflammasome and provides a potential target for intervention of diseases with uncontrolled inflammasome activation.
soluble Tim-3 might play inhibitory roles in impaired Tim-3-mediated clearance of apoptotic cells in systemic lupus erythematosus.
We found a novel mechanism through which Tim-3 could suppress antitumor immunity by utilizing the suppression of CD4 (show CD4 ELISA Kits)(+) follicular helper cells (Tfh) function and provide new insight in the regulation of Tfh cells in breast cancer patients
Tim3/Gal-9 (show LGALS9 ELISA Kits) alleviates the inflammation of TAO patients via suppressing Akt (show AKT1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) signaling pathway.
this study shows that severe aplastic anemia untreated patients have lower TIM-3 expression on NK cells and CD56dim NK subsets compared with normal controls, and are correlated with the severity of pancytopenia of SAA (show SAA1 ELISA Kits)
We conclude that Tim-3 is a biomarker of dysfunctional plasmacytoid dendritic cells
The present study defines the minimal TIM-3 promoter region and demonstrates its interaction with c-Jun (show JUN ELISA Kits) during TIM-3 transcription in CD4 (show CD4 ELISA Kits)(+) T cells.
Our findings establish intratumoral Tim-3(+)PD1 (show PDCD1 ELISA Kits)(+)CD8 (show CD8A ELISA Kits)(+) T cells as critical mediators of an aggressive phenotype in RCC (show XRCC1 ELISA Kits).
demonstrated that both IL-10 (show IL10 ELISA Kits) and TGF-beta (show TGFB1 ELISA Kits) upregulated TIM-3 surface expression on dendritic cells via a common signaling pathway that involved sequential activation of c-Src (show SRC ELISA Kits) and Bruton's tyrosine kinase (show BTK ELISA Kits)
Methylation level of the TIM-3 promoter gradually decreased after each round of T-cell polarization, and this decrease was inversely correlated with TIM-3 expression.
in mice, TIM-3 is not essential for development of HDM (show HDAC3 ELISA Kits)-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM (show HDAC3 ELISA Kits)-induced chronic allergic airway inflammation.
Authors found that a CD8 (show CD8A ELISA Kits)(+) T-cell population with age-associated exhaustion was distinguishable by its expression of Tim-3.
TIM4 (show TIMD4 ELISA Kits) binds TIM3 on the surface of polarized Th1 (show HAND1 ELISA Kits) cells to induce Th1 (show HAND1 ELISA Kits) cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.
The Gal-9 (show LGALS9 ELISA Kits)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.
TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.
Tim-3 acts at a receptor-proximal point to enhance Lyn (show LYN ELISA Kits) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (show FCER1A ELISA Kits) ligation.
Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
hepatitis A virus cellular receptor 2
, T cell immunoglobulin mucin 3
, T cell immunoglobulin mucin-3
, T-cell immunoglobulin and mucin domain-containing protein 3
, T-cell membrane protein 3
, kidney injury molecule-3
, T-cell immunoglobulin and mucin domain containing 3
, hepatitis A virus cellular receptor 2 homolog