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Browse our ME1 Proteins (ME1)

Full name:
Malic Enzyme 1, NADP(+)-Dependent, Cytosolic Proteins (ME1)
On are 5 Malic Enzyme 1, NADP(+)-Dependent, Cytosolic (ME1) Proteins from 4 different suppliers available. Additionally we are shipping ME1 Antibodies (52) and many more products for this protein. A total of 61 ME1 products are currently listed.
A130037E08Rik, ALF1, bHLHb20, D9Ertd267e, HEB, HEBAlt, HTF-4, HTF4, HUMNDME, Mdh-1, ME1, MES, Mod-1, MOD1, REB, zgc:153079
list all proteins Gene Name GeneID UniProt
ME1 4199 P48163
ME1 17436 P06801
ME1 24552  

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Human Malic Enzyme 1, NADP(+)-Dependent, Cytosolic (ME1) interaction partners

  1. ME1/ME2 expression phenotype may have a potential to be a valuable marker for sebaceous differentiation in sebaceous lesions.

  2. ME1 expression was found to be mutant-KRAS-associated in NSCLC cancer cell lines. Patients with elevated ME1 had worse outcomes after radiotherapy. Transamination generating cytosolic NADPH via ME1 may contribute to radioresistance.

  3. ME1 overexpression associates with unfavorable prognoses in patients with HCC (show FAM126A Proteins), suggesting that ME1 is a poor prognostic predictor of hepatocellular carcinoma.

  4. essential role for ME1 in the production of cytosolic NADPH (show NQO1 Proteins) and maintenance of migratory and invasive abilities of nasopharyngeal carcinoma cells

  5. the differential protein stability between dimer and tetramer interface interactions of human c-NADP-ME

  6. p53 (show TP53 Proteins) represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells

  7. cytosolic malic enzyme 1 gene polymorphism is associated with the degree of suppression of parathyroid hormone (show PTH Proteins) after long-term calcium supplementation; the effect is probably mediated through an increase in intestinal calcium absorption

  8. ME1 is a functional target gene of the BACH1 (show BACH1 Proteins) transcription factor according to ChIP-seq and knockdown analysis in HEK (show EPHA3 Proteins) 293 cells.

  9. that the single mutation of Gln362 to Lys in human m-NAD-ME changes it to an NADP+-dependent enzyme, which is characteristic because it is non-allosteric, non-cooperative, and NADP+-specific

  10. although ME1 overexpression augments anaplerosis and glucose stimulated insulin (show INS Proteins) secretion in INS-1 (show FOXM1 Proteins) 832/13 cells, it is not likely involved in methyl succinate and glucose stimulated insulin (show INS Proteins) secretion in pancreatic islets

Pig (Porcine) Malic Enzyme 1, NADP(+)-Dependent, Cytosolic (ME1) interaction partners

  1. This lack of consistency across families, combined with the fact that the ME1 mutation is synonymous and that the two DECR1 (show DECR1 Proteins) polymorphisms are conservative, suggests that the associations found are not causative.

  2. Transcript level of the porcine ME1 gene is affected by SNP in its 3'UTR, which is also associated with subcutaneous fat thickness.

  3. Malic enzyme 1 genotype is associated with backfat thickness and meat quality traits in pigs.

Cow (Bovine) Malic Enzyme 1, NADP(+)-Dependent, Cytosolic (ME1) interaction partners

  1. Six novel SNPs, five in ME1 and one in NR0B2 (show NR0B2 Proteins), were identified as candidates that have effects on meat and carcass quality traits.

  2. ME1-Dra I genotypes had a significant effect on cooking loss.

Mouse (Murine) Malic Enzyme 1, NADP(+)-Dependent, Cytosolic (ME1) interaction partners

  1. This study showed that (2)H-labeled tracers enable dissection of NADPH (show FDXR Proteins) production routes across cell types and environmental conditions.

  2. ME1 expression was found to be mutant-KRAS-associated in an NSCLC mouse model.

  3. HEB is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells

  4. severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 (show TCF12 Proteins) and Twist1 (show TWIST1 Proteins) genes highlights the key role of TCF12 (show TCF12 Proteins) acting with TWIST1 (show TWIST1 Proteins) in the normal development of the coronal sutures

  5. p53 (show TP53 Proteins) represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 (show TCF4 Proteins) in human and mouse cells

  6. Deficiency in the E proteins, E2A (show TCF3 Proteins) and HEB, led to increased frequency of terminally differentiated effector KLRG1 (show KLRG1 Proteins)(hi) CD8 (show CD8A Proteins)(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.

  7. Deletion of HEB and E2A (show TCF3 Proteins) in DP thymocytes specifically blocked the development of CD4 (show CD4 Proteins)(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 (show ID3 Proteins) allowed CD4 (show CD4 Proteins)(+) T cell development but blocked CD8 (show CD8A Proteins)(+) lineage development.

  8. the earliest event in B-cell specification involves the induction of FOXO1 (show FOXO1 Proteins) expression and requires the combined activities of E2A (show TCF3 Proteins) and HEB

  9. These results showed a new set of interactions between HEB, Notch1 (show NOTCH1 Proteins), and GATA3 (show GATA3 Proteins) that regulate the T-cell fate choice in developing thymocytes.

  10. Developmental progression of fetal HEB(-/-) precursors to the pre-T-cell stage is restored by HEBAlt.

ME1 Protein Profile

Protein Summary

This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.

Alternative names and synonyms associated with ME1

  • malic enzyme 1, NADP(+)-dependent, cytosolic (ME1)
  • malic enzyme 1, NADP(+)-dependent, cytosolic (me1)
  • malic enzyme 1, NADP(+)-dependent, cytosolic (Me1)
  • transcription factor 12 (Tcf12)
  • A130037E08Rik protein
  • ALF1 protein
  • bHLHb20 protein
  • D9Ertd267e protein
  • HEB protein
  • HEBAlt protein
  • HTF-4 protein
  • HTF4 protein
  • HUMNDME protein
  • Mdh-1 protein
  • ME1 protein
  • MES protein
  • Mod-1 protein
  • MOD1 protein
  • REB protein
  • zgc:153079 protein

Protein level used designations for ME1

NADP-dependent malic enzyme , cytosolic malic enzyme 1 , malic enzyme 1, NADP(+)-dependent, cytosolic , cytosolic malic enzyme 1-like , NADP-dependent malic enzyme-like , Malic enzyme, cytoplasmic , NADP-ME , malate dehydrogenase , malic enzyme 1, soluble , pyruvic-malic carboxylase , malate dehydrogenase decarboxylase (NADP+) , malic enzyme 1, NADP(+)-dependent, cytoplasmic (cytosolic, soluble) , malic enzyme, supernatant , malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) , DNA-binding protein HTF4 , E-box-binding protein , TCF-12 , class A helix-loop-helix transcription factor ME1 , transcription factor HTF-4

100070127 Equus caballus
100189620 Ovis aries
462853 Pan troglodytes
694739 Macaca mulatta
768196 Danio rerio
100024530 Monodelphis domestica
100125332 Meleagris gallopavo
100145399 Xenopus (Silurana) tropicalis
100355457 Oryctolagus cuniculus
100367220 Saccoglossus kowalevskii
100407892 Callithrix jacchus
100601685 Nomascus leucogenys
374189 Gallus gallus
4199 Homo sapiens
397538 Sus scrofa
540985 Bos taurus
17436 Mus musculus
24552 Rattus norvegicus
403709 Canis lupus familiaris
21406 Mus musculus
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