Browse our PLIN2 Proteins (PLIN2)

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Perilipin 2 Proteins (PLIN2)
On are 19 Perilipin 2 (PLIN2) Proteins from 9 different suppliers available. Additionally we are shipping PLIN2 Antibodies (189) and PLIN2 Kits (32) and many more products for this protein. A total of 246 PLIN2 products are currently listed.
AA407157, Adfp, adipophilin, ADPH, Adrp, DKFZp469F1012, fatvg, MGC76047, perilipin-2, PLIN2
list all proteins Gene Name GeneID UniProt
PLIN2 123 Q99541
PLIN2 11520 P43883
Rat PLIN2 PLIN2 298199  

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PLIN2 Proteins (PLIN2) by Origin

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Human Perilipin 2 (PLIN2) interaction partners

  1. Interference with PLIN2 and PPARalpha (show PPARA Proteins) resulted in major alterations in gene expression, especially affecting lipid, glucose, and purine metabolism.

  2. This study shows that hepatitis C virus suppresses hepatic ADRP expression in infected patients and cell lines. Forcing the expression of miR (show MLXIP Proteins)-148a and miR (show MLXIP Proteins)-30a limits the suppressive effect of hepatitis C virus on ADRP.

  3. ADP was expressed in a small proportion of lung adenocarcinoma suggesting that ADP-positive lung adenocarcinoma could be a distinct subtype of lung adenocarcinoma, induced by up-regulation of the lipogenic pathway.

  4. Activation of ARF1 (show ARF1 Proteins) dissociates ADRP from lipid droplets. A constitute active form of ARF1 (show ARF1 Proteins) (ARF1Q71I) promotes HCV assembly. ADRP played a positive role in Hepatitis C virus replication and negative role in Hepatitis C virus assembly.

  5. PLIN2 expression is significantly upregulated in human masticatory mucosa during wound healing

  6. Adipophilin was present in 24 of 26 colorectal hyperplastic polyps, but did not correlate with presence of white opaque substance (i.e. lipid droplets) on magnifying endoscopy with narrow band imaging.

  7. Conserved amphipathic helices mediate lipid droplet targeting of PLIN1 (show PLIN1 Proteins), PLIN2, and PLIN3 (show PLIN3 Proteins).

  8. In hepatitis C virus -infected human livers, occludin (show OCLN Proteins) and ADRP mRNA expression levels correlated with each other. Hepatitis C virus increases occludin (show OCLN Proteins) expression via the upregulation of ADRP.

  9. PLIN2 involves lipid modulation of GSK3 activity, GSK3 substrate expression, and cell growth/survival.

  10. PLIN2 inhibits insulininduced glucose uptake by activating NLRP3 (show NLRP3 Proteins), caspase1 (show CASP1 Proteins) and IL1beta (show IL1B Proteins), leading to a decreased IRS1 (show IRS1 Proteins) expression.

Cow (Bovine) Perilipin 2 (PLIN2) interaction partners

  1. These results demonstrate that bovine embryos at the blastocyst stage expressed ADRP mRNA and protein, and that the embryonic culture system modified this expression.

  2. Adipophilin and TIP47 (show PLIN3 Proteins) are expressed in lipid droplets of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes.

  3. 25 novel polymorphisms were identified within all exons and their flanking regions of ADFP, including the promoter region.

Mouse (Murine) Perilipin 2 (PLIN2) interaction partners

  1. Plin2 liver-specific ablation alleviates diet-induced hepatic steatosis and inflammation via a PEMT (show PEMT Proteins)-mediated mechanism.

  2. The relationship between M1-/M2-macrophage polarization and Adp-rich hepatocyte-consisting pseudolobules (PLs (show CTSC Proteins)) was investigated in thioacetamide (TAA)-induced rat cirrhosis.

  3. results identify PLIN2 as a determinant of global changes in the hepatic lipidome and suggest the hypothesis that these actions contribute to SREBP-regulated de novo lipogenesis involved in non-alcoholic fatty liver disease.

  4. Taken together, these findings demonstrate that artesunate inhibits adipogenesis in 3T3-L1 preadipoytes through the reduced expression and/or phosphorylation levels of C/EBP-alpha (show CEBPA Proteins), PPAR-gamma (show PPARG Proteins), FAS (show FAS Proteins), perilipin A (show PLIN1 Proteins), and STAT-3 (show STAT3 Proteins).

  5. phosphorylation of PLIN2 is dependent on AMPK (show PRKAA1 Proteins) and occurs after the interaction of PLIN2 with the chaperone-mediated autophagy chaperone HSPA8/Hsc70 (show HSPA8 Proteins).

  6. demonstrate a mutually beneficial relationship between PLIN2 deficiency and elevated apoA-I (show APOA1 Proteins)/HDL (show HSD11B1 Proteins)-C in preventing atherosclerosis development

  7. our findings highlight the relationship between protein stability and a previously unnoticed function of Plin2 during lipolysis in adipocytes.

  8. PLIN2 involves lipid modulation of GSK3 activity, GSK3 substrate expression, and cell growth/survival.

  9. Plin2 modulates rapid effects of diet on fecal lipid levels, enterocyte CLD (show LMF1 Proteins) contents, and fuel utilization properties of mice that correlate with structural and functional differences in their gut (show GUSB Proteins) microbial communities

  10. Postprandial triglyceride rich lipoproteins may be involved in atherosclerotic plaque formation through the regulation of perilipin-2 and perilipin-3 (show PLIN3 Proteins) proteins in macrophages.

Pig (Porcine) Perilipin 2 (PLIN2) interaction partners

  1. PLIN1 (show PLIN1 Proteins) and PLIN2 have been evaluated as candidate genes for growth, carcass and meat quality traits in pigs; two single-nucleotide polymorphisms, one in intron 2 of the PLIN1 (show PLIN1 Proteins) gene (JN860199:g.173G>A) and the 3' untranslated region of the PLIN2 gene (GU461317:g.98G>A); results obtained indicate that the PLIN2 polymorphism could be a useful marker for lean growth.

  2. These findings suggested that PLIN2 was a major lipid droplet-associated protein (show PLIN1 Proteins) in porcine oocytes.

  3. In pig muscle PLIN1 (show PLIN1 Proteins) and PLIN2 proteins are localized in correspondence with extra and intra-myocellular lipids, respectively.

  4. PLIN2 can be a marker for carcass quality in pigs.

PLIN2 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with PLIN2

  • perilipin 2 (plin2)
  • adipophilin (LOC100304704)
  • Adipophilin (adfp)
  • perilipin 2 (PLIN2)
  • perilipin 2 (Plin2)
  • AA407157 protein
  • Adfp protein
  • adipophilin protein
  • ADPH protein
  • Adrp protein
  • DKFZp469F1012 protein
  • fatvg protein
  • MGC76047 protein
  • perilipin-2 protein
  • PLIN2 protein

Protein level used designations for Perilipin 2 Proteins (PLIN2)

perilipin 2 , adipose differentiation-related protein , adipophilin , Adipophilin , perilipin-2 , ADRP , adipose differentiation related protein , adipocyte differentiation-related protein

394560 Xenopus (Silurana) tropicalis
398143 Xenopus laevis
100304704 Ictalurus punctatus
100380740 Salmo salar
465012 Pan troglodytes
100172891 Pongo abelii
100016609 Monodelphis domestica
123 Homo sapiens
280981 Bos taurus
11520 Mus musculus
298199 Rattus norvegicus
100338869 Oryctolagus cuniculus
397402 Sus scrofa
100861245 Capra hircus
474720 Canis lupus familiaris
427237 Gallus gallus
100125354 Ovis aries
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