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anti-Human SP1 Antibodies:
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Human Polyclonal SP1 Primary Antibody for ChIP, WB - ABIN2668968
Wang, Mayhew, Chen, Johnston, Mitra: "Calling cards" for DNA-binding proteins in mammalian cells. in Genetics 2012
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Human Polyclonal SP1 Primary Antibody for ChIP, ICC - ABIN153171
Gui, Song, Han, Zhou, Sheu: Involvement of the GC-rich sequence and specific proteins (Sp1/Sp3) in the basal transcription activity of neurogranin gene. in Biochemical and biophysical research communications 2006
Show all 4 Pubmed References
Human Polyclonal SP1 Primary Antibody for IHC (p), IP - ABIN153172
Lay, Hong, Huang, Yang, Pao, Liu, Lai, Lai, Cheng, Su, Chuang: Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL. in Cancer research 2007
Show all 3 Pubmed References
Human Monoclonal SP1 Primary Antibody for WB - ABIN1944791
Takahara, Kanazu, Yanagisawa, Akanuma: Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing. in The Journal of biological chemistry 2000
Show all 2 Pubmed References
Human Polyclonal SP1 Primary Antibody for ELISA, WB - ABIN250563
Sakuntabhai, Turbpaiboon, Casadémont, Chuansumrit, Lowhnoo, Kajaste-Rudnitski, Kalayanarooj, Tangnararatchakit, Tangthawornchaikul, Vasanawathana, Chaiyaratana, Yenchitsomanus, Suriyaphol, Avirutnan et al.: A variant in the CD209 promoter is associated with severity of dengue disease. ... in Nature genetics 2005
Show all 2 Pubmed References
Human Polyclonal SP1 Primary Antibody for IP, WB - ABIN2476560
Stark, Assaraf: Loss of Sp1 function via inhibitory phosphorylation in antifolate-resistant human leukemia cells with down-regulation of the reduced folate carrier. in Blood 2006
Human Polyclonal SP1 Primary Antibody for ELISA, WB - ABIN562963
: in 1970
Human Polyclonal SP1 Primary Antibody for IF (p), IHC (p) - ABIN730468
Peng, Shi, Du, Wang, Klocker, Mo, Mo, Zhang: Prostaglandin E2 induces stromal cell-derived factor-1 expression in prostate stromal cells by activating protein kinase A and transcription factor Sp1. in The international journal of biochemistry & cell biology 2013
A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (show ATP7A Antibodies), sp1 and sod1 (show SOD1 Antibodies) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
High SP1 (show PSG1 Antibodies) expression is associated with obesity.
The up-regulation of Hsp27 (show HSPB1 Antibodies) by E2 is mediated by ERalpha (show ESR1 Antibodies)/Sp1 (show PSG1 Antibodies).
Identification of heteromolecular binding sites in transcription factors Sp1 (show PSG1 Antibodies) and TAF4 (show TAF4 Antibodies) using high-resolution nuclear magnetic resonance spectroscopy has been reported.
Stimulation of ribosomal RNA gene promoter by transcription factor Sp1 involves active DNA demethylation by Gadd45 (show GADD45A Antibodies)-NER (show NR1H2 Antibodies) pathway.
TIP60 (show KAT5 Antibodies)-mediated growth suppression of HPV-induced cervical cancer is mediated in part due to TERT (show TERT Antibodies) repression through Sp1 (show PSG1 Antibodies) acetylation. In summary, our study has identified a novel substrate for TIP60 (show KAT5 Antibodies) catalytic activity and a unique repressive mechanism acting at the TERT (show TERT Antibodies) promoter in virus-induced malignancies.
AGEs treatment increased the expression of RAGE (show AGER Antibodies), Sp1 (show PSG1 Antibodies), and MMP2 (show MMP2 Antibodies) in a dose-dependent manner.
E6 upregulation of hTERT by downregulated LKB1 (show STK11 Antibodies) and upregulated SP1 (show PSG1 Antibodies) in lung cancer cells. These results indicated that E6 played a predominant role in the regulation of telomerase activation and may be a valuable therapeutic targets for HPV-related cancer.
Results have shown crosstalk among the EGFR (show EGFR Antibodies) cascade and Sp1 (show PSG1 Antibodies) and DPD (show DPYD Antibodies) expressions in EGFR (show EGFR Antibodies) mutant non-small-cell lung cancer cell lines. EGF (show EGF Antibodies)-induced Sp1 (show PSG1 Antibodies) up-regulation resulted in both DPYD (show DPYD Antibodies) mRNA and DPD (show DPYD Antibodies) protein expressions.
AKT (show AKT1 Antibodies)/GSK-3beta (show GSK3b Antibodies)-mediated stabilization of SP1 (show PSG1 Antibodies) is required for TGF-beta (show TGFB1 Antibodies) induced up-regulation of NKG2DLs.
miR-612 has a suppressive role on hepatocellular carcinoma cell stemness via Sp1/Nanog signaling pathway.
study demonstrates the co-expression of DLX3 (show DLX3 Antibodies), PPARG (show PPARG Antibodies) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (show PTH Antibodies) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN (show FASN Antibodies) promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (show PRNP Antibodies) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (show PRNP Antibodies) promoter and its activity.
Using MA, we demonstrated Sp1 as a critical stemness-related transcriptional factor protecting GBM cells against stress- and TMZ-induced death. Thus, Sp1 inhibition may prevent recurrence of malignant cells persisting after primary therapy.
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 (show NFATC1 Antibodies) and Sp1, reducing the level of free Sp1 to inhibit microRNA miR (show MLXIP Antibodies)-139-5p expression and promote osteoclastogenesis.
data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1/SIRT1 (show SIRT1 Antibodies) signaling pathway.
This resulted in Sp1 displacement from the promoter and binding of Sp3 (show SP3 Antibodies) to it, leading to p300 (show NOTCH1 Antibodies) recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 (show TLR5 Antibodies) expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3 (show SP3 Antibodies)-mediated gene regulation that may apply to other genes
adrenergic stimulation induced complex formation between Ifrd1 (show IFRD1 Antibodies), Sp1 and mSIN3B, which is a component of the SIN (show POLR3E Antibodies) complex containing histone deacetylase (show HDAC1 Antibodies), in brown adipocytes. These findings, therefore, suggest that Ifrd1 (show IFRD1 Antibodies) could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
Dp71 (show DMD Antibodies) expression in hepatic cells is carried out, in part, by YY1 (show YY1 Antibodies)-, Sp1- and Sp3 (show SP3 Antibodies)-mediated transcription from the Dp71 (show DMD Antibodies) promoter.
SP1 expression was up-regulated in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion.MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells.
miR (show MLXIP Antibodies)-124, -128, and -137 act synergistically to regulate Sp1 expression.
YY1 (show YY1 Antibodies) and SP1 independently and cooperatively govern the Mesp1 (show MESP1 Antibodies) expression during embryogenesis.
Taken together, these results indicate that the transcription factor Sp1 upregulates the proximal promoter activity of the mouse Col11a1 (show COL11A1 Antibodies) gene in chondrocytes.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1