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Browse our NEU2 Proteins (NEU2)

Full name:
Sialidase 2 (Cytosolic Sialidase) Proteins (NEU2)
On are 8 Sialidase 2 (Cytosolic Sialidase) (NEU2) Proteins from 6 different suppliers available. Additionally we are shipping NEU2 Antibodies (59) and NEU2 Kits (4) and many more products for this protein. A total of 75 NEU2 products are currently listed.
list all proteins Gene Name GeneID UniProt
NEU2 23956 Q9JMH3
NEU2 29204  
NEU2 4759 Q9Y3R4

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NEU2 Proteins (NEU2) by Origin

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Mouse (Murine) Sialidase 2 (Cytosolic Sialidase) (NEU2) interaction partners

  1. Neu2 from thymus exhibited sialidase activity with fetuin (show AHSG Proteins) at pH 7.0.

  2. Our data demonstrate that IGF-1 (show IGF1 Proteins)-induced myoblast differentiation and hypertrophy are driven, at least in part, by Neu2 upregulation and further support the significant role of cytosolic sialidase in myoblasts.

  3. the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene

  4. 30-40% of B and C forms of Neu2 activity was located in the crude membrane-fraction, and hydrolyzed ganglioside effectively, while both soluble fraction showed particular behavior with substrate specificity.

Human Sialidase 2 (Cytosolic Sialidase) (NEU2) interaction partners

  1. cytosolic GBA3 (show GBA3 Proteins) is likely involved in the catabolism of cytosolic sialyl free N-glycans, possibly by stabilizing the activity of the NEU2 protein

  2. Circular dichroism (CD) spectra at variable temperatures have been recorded for human cytosolic sialidase NEU2 in buffered water solutions and in the presence of divalent cations.

  3. Q136K is a novel mutation in an expressed NEU2 protein that was discovered during crystallographic analysis.

  4. the present study demonstrated NEU2 expression to be detectable but very low in many human tissues and cells, and suggested possible functional roles in PC-3 (show PCSK1 Proteins) prostate cancer cells.

  5. NEU2 appears to be activated when lysine 45 and glutamine 112 are mutated to alanine.

  6. the first high resolution x-ray structures of sialidase, human Neu2

  7. Neu2 loss of expression might exacerbate the defective myogenic differentiation of rhabdomyosarcoma cells.

NEU2 Protein Profile

Protein Summary

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.

Alternative names and synonyms associated with NEU2

  • sialidase 2 (cytosolic sialidase) (NEU2)
  • neuraminidase 2 (Neu2)
  • sialidase 2 (Neu2)
  • MBS protein
  • MSS protein
  • MTS protein
  • NEU2 protein
  • SIAL2 protein

Protein level used designations for NEU2

sialidase 2 (cytosolic sialidase) , sialidase-2-like , N-acetyl-alpha-neuraminidase 2 , brain sialidase , cystolic sialidase , cytosolic sialidase , murine thymic sialidase , sialidase-2 , skeletal muscle sialidase , neuraminidase 2

486166 Canis lupus familiaris
713979 Macaca mulatta
768823 Gallus gallus
100404163 Callithrix jacchus
100598166 Nomascus leucogenys
23956 Mus musculus
29204 Rattus norvegicus
4759 Homo sapiens
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