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Browse our Dicer 1, Ribonuclease Type III Proteins (DICER1)

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Dicer 1, Ribonuclease Type III Proteins (DICER1)
On are 3 Dicer 1, Ribonuclease Type III (DICER1) Proteins from 2 different suppliers available. Additionally we are shipping Dicer 1, Ribonuclease Type III Antibodies (135) and Dicer 1, Ribonuclease Type III Kits (9) and many more products for this protein. A total of 148 Dicer 1, Ribonuclease Type III products are currently listed.
1110006F08Rik, D12Ertd7e, DCR1, DICER, dicer1, fc39d11, fc74b05, HERNA, mKIAA0928, MNG1, wu:fc39d11, wu:fc74b05
list all proteins Gene Name GeneID UniProt
Mouse DICER1 DICER1 192119  
DICER1 23405 Q9UPY3
Rat DICER1 DICER1 299284  

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Dicer 1, Ribonuclease Type III Proteins (DICER1) by Origin

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Top referenced Dicer 1, Ribonuclease Type III Proteins

  1. Human DICER1 Protein expressed in Human - ABIN2719477 : Zhang, Li, Deng, Liu, Chen, Tang, Wang, Cao, Fang, Wen, Xu, Chen, Shi, Li, Xie, Tang: Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents. in Nucleic acids research 2016 (PubMed)

More Proteins for Dicer 1, Ribonuclease Type III Interaction Partners

Mouse (Murine) Dicer 1, Ribonuclease Type III (DICER1) interaction partners

  1. In Dicer-deficient mice Orai1 (show TMEM132A Proteins) was down-regulated at mRNA and protein level in CD4 (show CD4 Proteins)+ T cells.

  2. Dicer-deficient mice exhibited an exaggerated seizure response, enhanced induction of immediate early (show JUN Proteins) genes in response to different stimuli, stronger and more stable fear memory, hyperphagia, and increased excitability of CA1 (show CA1 Proteins) pyramidal neurons.

  3. Our results suggest that DICER-dependent pathways control the formation and organization of cell-cell junctions in the seminiferous epithelium via the regulation of cell adhesion-related genes.

  4. Study suggested that loss of Gli2 mRNA mediated the anterior-restricted defect in conditional Dicer knockdown mice and showed that miR-106b positively regulated Gli2 mRNA expression

  5. these findings indicate that Dicer1-dependent generation of mature miRNAs in late-stage MKs (show MKKS Proteins) and platelets modulates the expression of target mRNAs important for the hemostatic and thrombotic function of platelets.

  6. reveal Dicer1-miR (show MLXIP Proteins)-328-Bace1 (show BACE Proteins) signalling as a determinant of brown adipose tissue function

  7. Dicer promotes endothelial maladaptation and atherosclerosis in part by miR (show MLXIP Proteins)-103-mediated suppression of KLF4 (show KLF4 Proteins).

  8. Suggest recurrent DICER1 hotspot mutations in endometrial tumours impact on microRNA biogenesis.

  9. data indicate that oocyte DICER expression in the fetal ovary is required, and oocyte DROSHA (show DROSHA Proteins) is dispensable, for postnatal follicular development and female fertility in adulthood.

  10. Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia.

Human Dicer 1, Ribonuclease Type III (DICER1) interaction partners

  1. Dicer can efficiently bind single-stranded RNAs that are longer than ~20-nucleotides.

  2. downregulation of Dicer in von Hippel-Lindau-deficient clear cell renal cell carcinoma (show MOK Proteins) contributes to high levels of HIF-2alpha (show EPAS1 Proteins) and a malignant phenotype, which suggests Dicer could be a useful therapeutic target for managing this disease.

  3. DICER, DROSHA (show DROSHA Proteins) and DNA damage response RNAs act in the response to DNA damage after primary recognition of DNA lesions and, together with gammaH2AX (show H2AFX Proteins), are essential for enabling the secondary recruitment of DDR (show DDR1 Proteins) factors and fuel the amplification of DDR (show DDR1 Proteins) signaling.

  4. DICER1 syndrome may have an even broader phenotypic spectrum and seems to be associated with rare forms of T cell Hodgkin lymphoma.

  5. high proportion of recurrent somatic DICER1 and KMT2D mutations in this series of sporadic IO-MEPL points to their likely important roles in the molecular pathogenesis of these rare embryonal tumors

  6. essential function of Dicer in resolving the spontaneous DNA damage that occurs during the rapid proliferation of developmental progenitors and malignant cells.

  7. Two patients with ovarian Sertoli-Leydig cell tumors and a germline intronic mutation in DICER1 are reported

  8. the microdeletion included the DICER1 gene. Mutations of DICER1 has been associated with an increased risk for pleuropulmonary blastoma (PPB (show HTN1 Proteins))

  9. the expression of MYCN (show MYCN Proteins), HMGA2, and DICER1 seems to be correlated to each other and the expression of the let7-genes impacted by their expression.

  10. Our results suggest that DICER1 mutations may not have a role in testicular sex cord-stromal tumorigenesis

Pig (Porcine) Dicer 1, Ribonuclease Type III (DICER1) interaction partners

  1. Diminished androgen action during gestation induces changes in Dicer1 mRNA expression.

  2. The primary cDNA sequence of porcine Dicer was determined, and its expression in porcine oocytes and early stage embryos was confirmed.

Cow (Bovine) Dicer 1, Ribonuclease Type III (DICER1) interaction partners

  1. Studied Dicer gene expression during early bovine embryo development.An increase in Dicer expression was detected in the mature oocytes sampled (P<0.05), implying that gene repression occurs during meiosis II.

Zebrafish Dicer 1, Ribonuclease Type III (DICER1) interaction partners

  1. Dynamic miRNA expression patterns during retinal regeneration in zebrafish: reduced dicer or miRNA expression suppresses proliferation of Muller glia-derived neuronal progenitor cells

Dicer 1, Ribonuclease Type III (DICER1) Protein Profile

Protein Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Dicer 1, Ribonuclease Type III (DICER1)

  • dicer 1, ribonuclease type III (DICER1)
  • endoribonuclease Dicer (CpipJ_CPIJ010534)
  • dicer 1, ribonuclease type III (dicer1)
  • double-stranded RNA-specific endoribonuclease type III (dicer1)
  • dicer 1, ribonuclease type III (Dicer1)
  • Dicer1, Dcr-1 homolog (Drosophila) (dicer1)
  • 1110006F08Rik protein
  • D12Ertd7e protein
  • DCR1 protein
  • DICER protein
  • dicer1 protein
  • fc39d11 protein
  • fc74b05 protein
  • HERNA protein
  • mKIAA0928 protein
  • MNG1 protein
  • wu:fc39d11 protein
  • wu:fc74b05 protein

Protein level used designations for DICER1

Dicer1, Dcr-1 homolog , endoribonuclease Dicer , dicer 1, ribonuclease type III , double-stranded RNA-specific endoribonuclease type III , double-strand-specific ribonuclease mDCR-1 , K12H4.8-LIKE , dicer 1, double-stranded RNA-specific endoribonuclease , helicase MOI , helicase with RNAse motif , helicase-moi , dicer , dsRNA-specific ribonuclease

453137 Pan troglodytes
480426 Canis lupus familiaris
702516 Macaca mulatta
6043055 Culex quinquefasciatus
100065648 Equus caballus
100170154 Xenopus (Silurana) tropicalis
100227750 Taeniopygia guttata
100316917 Xenopus laevis
192119 Mus musculus
23405 Homo sapiens
299284 Rattus norvegicus
100505387 Sus scrofa
337871 Bos taurus
423437 Gallus gallus
100689239 Cricetulus griseus
324724 Danio rerio
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