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PSMD10/gankyrin (show PSMD10 ELISA Kits) has a role in inducing autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression
the ATG5 (show ATG5 ELISA Kits)-ATG7-NCOA4 (show NCOA4 ELISA Kits) autophagic pathway has a role in ferroptosis
knockdown of autophagy genes ATG5 (show ATG5 ELISA Kits) or ATG7 resulted in reduced hematopoietic stem/progenitor cell frequencies in vitro as well as in vivo.
Nine of the 32 (28.1%) iCCA patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 (show RNF2 ELISA Kits) mutations, two each (6.3%) of CACNA2D3 (show CACNA2D3 ELISA Kits) and RASSF1 (show RASSF1 ELISA Kits) mutations, and one each (3.1%) of ATG7 and PLCD1 (show PLCD1 ELISA Kits) mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.
knockdown of ATG7 results in decreased glycolysis and increased flux of labeled carbons through the mitochondrial tricarboxylic acid cycle.
SNP rs11706903 in ATG7 was not associated with systemic lupus erythematosus I Chinese Han population.
low serum ATG7 is associated with ulcerative colitis
The U2AF35 (show U2AF1 ELISA Kits)(S34F) mutation alters interaction with CFIm59 (show CPSF7 ELISA Kits), leading to increased use of a distal cleavage and polyadenylation site in the ATG7 pre-mRNA, decreasing levels of ATG7 protein and defective autophagy, ultimately leading to transformation.
the inhibition of Atg7 appears to be a valid strategy to enhance chemosensitivity, and it could indeed improve outcomes in acute myeloid leukemia (show BCL11A ELISA Kits) therapy.
Our data demonstrate that HOTAIR promotes the activation of autophagy in HCC (show FAM126A ELISA Kits) cells by upregulating the expression of the autophagy-related genes ATG3 (show ATG3 ELISA Kits) and ATG7.
ATG7 has a role in autophagy deficiency in macrophages that may contribute to the progression of metabolic syndrome associated with lipid injury and colitis
ATG proteins ATG5 (show ATG5 ELISA Kits) and ATG7 may be required for phagosome maturation under some conditions, but are not universally required for this process
Autophagy and tumorigenesis were not increased in Atg7(+/-) mice kept in social isolation and fed OID. Thus, social isolation may increase breast cancer risk by inducing autophagy, independent of changes in body weight.
ATG7, but not ATG13 (show ATG13 ELISA Kits) or ULK1 (show ULK1 ELISA Kits) has a role in functional autophagy in glioblastoma development
Atg7 is critical for the survival of midbrain dopaminergic (mDA) neurons in physiological condition. Atg7 is up-regulated when exposed to MPTP (show PTPN2 ELISA Kits), but unlike in the control mice, chronic MPTP (show PTPN2 ELISA Kits) treatment did not lead to loss of mDA neurons in Atg7 conditional knockout mice. These results suggest that excessive Atg7-involved autophagy in the pathological condition has deleterious effects on the survival of mDA neurons.
It shows that AMBRA1 (show AMBRA1 ELISA Kits), but not ATG7, plays a role in TCR-mediated control of glycolytic factors and mitochondrial mass, while both AMBRA1 (show AMBRA1 ELISA Kits) and ATG7 are required for autolysosome formation.
Collectively, these data reveal that miR (show MLXIP ELISA Kits)-20a inhibits autophagic response and promotes BCG (show SLC11A1 ELISA Kits) survival in macrophages by targeting ATG7 and ATG16L1 (show ATG16L1 ELISA Kits).
Beta-Atg7 (-/-) mice had proinsulin (show INS ELISA Kits)-containing sequestosome 1 (p62 (show SQSTM1 ELISA Kits) [also known as SQSTM1 (show SQSTM1 ELISA Kits)])(+) aggregates in beta cells, indicating proinsulin (show INS ELISA Kits) is regulated by autophagy in vivo. Short-term bafilomycin-A1 treatment and ATG5 (show ATG5 ELISA Kits)/7 knockdown increased steady-state proinsulin (show INS ELISA Kits) and hormone precursor chromogranin A (show CHGA ELISA Kits) content. ATG5 (show ATG5 ELISA Kits)/7 knockdown also increased glucose- and non-fuel-stimulated insulin (show INS ELISA Kits) secretion.
This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes.
autophagy-related protein 7
, Autophagy-related protein 7
, ATG7 autophagy related 7 homolog
, ATG12-activating enzyme E1 ATG7
, ubiquitin activating enzyme E1-like protein
, ubiquitin-activating enzyme E1-like protein
, ubiquitin-like modifier-activating enzyme ATG7
, autophagy-related 7
, autophagy related 7 homolog
, potential E1-like Atg12p-Atg5p conjugation enzyme Atg7