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SNP rs11706903 in ATG7 was not associated with systemic lupus erythematosus I Chinese Han population.
low serum ATG7 is associated with ulcerative colitis
The U2AF35 (show U2AF1 ELISA Kits)(S34F) mutation alters interaction with CFIm59 (show CPSF7 ELISA Kits), leading to increased use of a distal cleavage and polyadenylation site in the ATG7 pre-mRNA, decreasing levels of ATG7 protein and defective autophagy, ultimately leading to transformation.
the inhibition of Atg7 appears to be a valid strategy to enhance chemosensitivity, and it could indeed improve outcomes in acute myeloid leukemia (show BCL11A ELISA Kits) therapy.
Our data demonstrate that HOTAIR promotes the activation of autophagy in HCC (show FAM126A ELISA Kits) cells by upregulating the expression of the autophagy-related genes ATG3 (show ATG3 ELISA Kits) and ATG7.
Autophagy-related gene ATG7 was validated as a target of miR-17 seed family.
the upregulation of autophagy-related gene (Atg) and wingless/int1 (show WNT1 ELISA Kits) (Wnt (show WNT2 ELISA Kits)) signaling during BMP-2 (show BMP2 ELISA Kits)-mediated human osteoblastic differentiation, was examined.
Aldo was revealed to induce autophagy, as indicated by the increased conversion from microtubuleassociated protein 1A/1Blight chain 3 (LC3)I to LC3II, the increased expression levels of autophagyrelated gene 7 (Atg7) and the increased degradation of p62, which was accompanied by MC proliferation
PVT1 overexpression increased the expression of Atg7 and Beclin1 (show BECN1 ELISA Kits) by targeting miR (show MLXIP ELISA Kits)-186, which induced protective autophagy, thus promoting glioma vascular endothelial cell proliferation, migration, and angiogenesis. Therefore, PVT1 and miR (show MLXIP ELISA Kits)-186 can provide new therapeutic targets for future anti-angiogenic treatment of glioma
Genetic polymorphisms of ATG5 (show ATG5 ELISA Kits) and ATG7 could contribute to neutrophilic airway inflammation in the pathogenesis of adult asthma.
Atg7 is critical for the survival of midbrain dopaminergic (mDA) neurons in physiological condition. Atg7 is up-regulated when exposed to MPTP (show PTPN2 ELISA Kits), but unlike in the control mice, chronic MPTP (show PTPN2 ELISA Kits) treatment did not lead to loss of mDA neurons in Atg7 conditional knockout mice. These results suggest that excessive Atg7-involved autophagy in the pathological condition has deleterious effects on the survival of mDA neurons.
It shows that AMBRA1 (show AMBRA1 ELISA Kits), but not ATG7, plays a role in TCR-mediated control of glycolytic factors and mitochondrial mass, while both AMBRA1 (show AMBRA1 ELISA Kits) and ATG7 are required for autolysosome formation.
Collectively, these data reveal that miR (show MLXIP ELISA Kits)-20a inhibits autophagic response and promotes BCG (show SLC11A1 ELISA Kits) survival in macrophages by targeting ATG7 and ATG16L1 (show ATG16L1 ELISA Kits).
Beta-Atg7 (-/-) mice had proinsulin (show INS ELISA Kits)-containing sequestosome 1 (p62 (show SQSTM1 ELISA Kits) [also known as SQSTM1 (show SQSTM1 ELISA Kits)])(+) aggregates in beta cells, indicating proinsulin (show INS ELISA Kits) is regulated by autophagy in vivo. Short-term bafilomycin-A1 treatment and ATG5 (show ATG5 ELISA Kits)/7 knockdown increased steady-state proinsulin (show INS ELISA Kits) and hormone precursor chromogranin A (show CHGA ELISA Kits) content. ATG5 (show ATG5 ELISA Kits)/7 knockdown also increased glucose- and non-fuel-stimulated insulin (show INS ELISA Kits) secretion.
gene deletion results in accumulation of RPE65 (show RPE65 ELISA Kits) variant M450 in the retinal pigment epithelium
A conditional deletion of Atg7 in hepatocytes leads to hepatomegaly and in aged animals to liver tumors.
this study shows that knockdown of ATG7 enhances macrophage-associated (show CD163 ELISA Kits) phagocytosis and intracellular killing of Pseudomonas aeruginosa
specific ablation of autophagy gene 7 (Atg7) from kidney proximal tubules worsened Lipopolysaccharide-induced acute kidney injury.
These findings reveal that selective neuronal deletion of Atg7 is strongly protective against neuronal death.
This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes.
autophagy-related protein 7
, Autophagy-related protein 7
, ATG7 autophagy related 7 homolog
, ATG12-activating enzyme E1 ATG7
, ubiquitin activating enzyme E1-like protein
, ubiquitin-activating enzyme E1-like protein
, ubiquitin-like modifier-activating enzyme ATG7
, autophagy-related 7
, autophagy related 7 homolog
, potential E1-like Atg12p-Atg5p conjugation enzyme Atg7