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Browse our Calreticulin Proteins (CALR)

Full name:
Calreticulin Proteins (CALR)
On www.antibodies-online.com are 52 Calreticulin (CALR) Proteins from 12 different suppliers available. Additionally we are shipping Calreticulin Antibodies (293) and Calreticulin Kits (51) and many more products for this protein. A total of 416 Calreticulin products are currently listed.
Synonyms:
anon-EST:fe3D7, anon-EST:Liang-2.11, anon-EST:Liang-2.17, CALR, Calregulin, cC1qR, CG9429, clone 2.11, clone 2.17, Clr, crc, CRP55, CRT, Dmel\\CG9429, ERp60, eth, HACBP, NV19007, potp, RO, SSA, zgc:85636
list all proteins Gene Name GeneID UniProt
CALR 811 P27797
CALR 12317 P14211
CALR 64202 P18418

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Calreticulin Proteins (CALR) by Origin

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Top referenced Calreticulin Proteins

  1. Human Calreticulin Protein expressed in Escherichia coli (E. coli) - ABIN667783 : Kropp, Garg, Binder: Ovalbumin-derived precursor peptides are transferred sequentially from gp96 and calreticulin to MHC class I in the endoplasmic reticulum. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 2 references for ABIN667783

  2. Human Calreticulin Protein expressed in Human Cells - ABIN2005777 : Andrin, Pinkoski, Burns, Atkinson, Krahenbuhl, Hudig, Fraser, Winkler, Tschopp, Opas, Bleackley, Michalak: Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-cell granules. in Biochemistry 1998 (PubMed)

More Proteins for Calreticulin Interaction Partners

Fruit Fly (Drosophila melanogaster) Calreticulin (CALR) interaction partners

  1. Calreticulin plays a key role in olfactory system function, possibly by establishing its overall sensitivity to odorants.

  2. Calreticulin mediates hypersensitivity to diethylether and resistance to isoflurane in association with low expression of the gene.

  3. These results collectively indicate that calreticulin is the first molecule to be identified as a marker for phagocytosis of apoptotic cells by Drosophila phagocytes

Human Calreticulin (CALR) interaction partners

  1. Results suggest that lymphoproliferative and myeloproliferative neoplasms may coexist, although the pathogenetic mechanism of coexisting hematologic requires further investigation. Data indicate that JAK2 (show JAK2 Proteins) V617F and CALR mutations are not mutually exclusive and the actual frequency of simultaneous JAK2 (show JAK2 Proteins) V617F and CALR mutations is unknown.

  2. No MPL (show MPL Proteins) or CALR mutations were detected among the remaining 12 patients

  3. The CALR mutation profile in Irish essential thrombocythemia and primary myelofibrosis patients appears similar to that in other European populations.

  4. Fragment analysis is an accurate and sensitive method for the detection of CALR indels. The novel 9 bp deletion is likely a germline variant. Consequence of coexisting JAK2 (show JAK2 Proteins) V617F and CALR mutations requires careful interpretation.

  5. CALR mutations were frequent in Chinese patients with Essential Thrombocythemia , especially in those without JAK2 (show JAK2 Proteins) or MPL (show MPL Proteins) mutations.

  6. Screening for CALR mutations is essential in BCR-ABL (show ABL1 Proteins)-negative myeloproliferative neoplasms since it not only provides valuable diagnostic and prognostic information but also identifies potential treatment targets.

  7. Various calreticulin mutations were found in exon 9. Type 1 mutations, a 52-bp deletion in exon 9, were the most common and were observed in 23 cases. Type 2 mutations, a 5-bp insertion in exon 9, were identified in seven cases.

  8. Thrombocytosis and STAT5 (show STAT5A Proteins) activation in chronic myelogenous leukaemia are not consistently associated with CALR exon 9 or JAK2 (show JAK2 Proteins) V617F mutation.

  9. results suggest that calreticulin can serve as a biomarker of pancreatic cancer stem-like cells and a prognostic factor associated with poorer survival of pancreatic cancer patients

  10. overexpression of calreticulin(CALR) and heat shock 70kDa (show RPS6KB1 Proteins) protein 5 (show CAPS Proteins)(HSPA5 (show HSPA5 Proteins)) was further validated. CONCLUSION: Alltogether, abundant new candidate molecules, especially proteins related to ER-stress, were found to be involved in the pathogenesis of GD

Rabbit Calreticulin (CALR) interaction partners

  1. These findings suggest that protein kinase C is involved in the regulation of CRT function.

Mouse (Murine) Calreticulin (CALR) interaction partners

  1. This essential role of calreticulin in nucleocytoplasmic communication competency ties its regulatory action with proficiency of cardiac myofibrillogenesis essential for proper cardiac development.

  2. Study provides evidence that chronic stress activates calreticulin and might be one of the pathological mechanisms underlying the motor coordination and motor learning dysfunctions seen in social defeat mice.

  3. This study for the first time revealed that increased CRT (show SLC6A8 Proteins) inhibited Fas (show FAS Proteins)/FasL (show FASL Proteins)-mediated neuronal cell apoptosis during the early stage of ischemic stroke, suggesting it to be a potential protector activated soon after ischemia-reperfusion injury

  4. The findings highlight the importance of CALR in female reproduction and demonstrate that compromised CALR function leads to ovarian insufficiency and female infertility.

  5. Calreticulin mediates vascular smooth muscle cell responses to injury through the regulation of collagen deposition and neointima formation.

  6. CALR mutants are sufficient to induce thrombocytosis through MPL (show MPL Proteins) activation.

  7. Thrombopoietin receptor (show MPL Proteins) activation by myeloproliferative neoplasm associated calreticulin mutants.

  8. These studies reveal central roles for ATP and calcium binding as regulators of calreticulin-substrate interactions and as key determinants of PLC (show HSPG2 Proteins) dynamics.

  9. study demonstrates for the first time that LRH-1 (show NR5A2 Proteins) has a CRT (show SLC6A8 Proteins)-dependent NES (show NES Proteins) which is not only required for cytoplasmic trafficking, but also essential for correct protein folding to avoid misfolding-induced aggregation.

  10. Arginylated CRT has a longer half-life than non-arginylated CRT and displays different ubiquitin dependence.

Cow (Bovine) Calreticulin (CALR) interaction partners

  1. the lectin site of CRT is the main target for gentamicin binding

Pig (Porcine) Calreticulin (CALR) interaction partners

  1. Calreticulin is confined to subplasmalemmal vesicles partially overlapping with cortical granule contents. Its exocytosis after the oocyte activation seems to participate in the membrane block to polyspermy in pigs.

  2. Calreticulin was widely expressed in pig tissues and its transcripts were downregulated during maturation, especially at 44 hr, and were undetectable at the blastocyst stage.

Calreticulin (CALR) Protein Profile

Protein Summary

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.

Alternative names and synonyms associated with Calreticulin (CALR)

  • calreticulin (calr)
  • calreticulin (crt)
  • calreticulin (CRT)
  • Calreticulin (Crc)
  • calreticulin (LmjF31.2600)
  • calreticulin (Crc)
  • calreticulin (CALR)
  • calreticulin (Calr)
  • calreticulin (Crt)
  • calreticulin 2, calcium-binding protein (CRT2)
  • calreticulin 3 (CALR3)
  • anon-EST:fe3D7 protein
  • anon-EST:Liang-2.11 protein
  • anon-EST:Liang-2.17 protein
  • CALR protein
  • Calregulin protein
  • cC1qR protein
  • CG9429 protein
  • clone 2.11 protein
  • clone 2.17 protein
  • Clr protein
  • crc protein
  • CRP55 protein
  • CRT protein
  • Dmel\\CG9429 protein
  • ERp60 protein
  • eth protein
  • HACBP protein
  • NV19007 protein
  • potp protein
  • RO protein
  • SSA protein
  • zgc:85636 protein

Protein level used designations for Calreticulin Proteins (CALR)

calreticulin , CG9429-PA , CG9429-PB , Crc-PA , Crc-PB , anon-fast-evolving-3D7 , pot pourri , potpourri , ER-resident chaperone calreticulin , CRP55 , ERp60 , HACBP , Sicca syndrome antigen A (autoantigen Ro; calreticulin) , calregulin , endoplasmic reticulum resident protein 60 , grp60 , CABP3 , CALBP , calcium-binding protein 3 , calrectulin , Endoplasmic reticulum resident protein 60

GENE ID SPECIES
379788 Xenopus laevis
100136202 Oncorhynchus mykiss
100146083 Triticum aestivum
30248 Danio rerio
41166 Drosophila melanogaster
407962 Xenopus (Silurana) tropicalis
5654192 Leishmania major strain Friedlin
100116123 Nasonia vitripennis
100304608 Ictalurus punctatus
811 Homo sapiens
476694 Canis lupus familiaris
100009050 Oryctolagus cuniculus
12317 Mus musculus
64202 Rattus norvegicus
281036 Bos taurus
100381266 Sus scrofa
101104396 Ovis aries
100713922 Cavia porcellus
692629 Bombyx mori
100689096 Cricetulus griseus
5715514 Chlamydomonas reinhardtii
420146 Gallus gallus
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