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Browse our Calreticulin Proteins (CALR)

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Calreticulin Proteins (CALR)
On are 43 Calreticulin (CALR) Proteins from 12 different suppliers available. Additionally we are shipping Calreticulin Antibodies (275) and Calreticulin Kits (46) and many more products for this protein. A total of 384 Calreticulin products are currently listed.
anon-EST:fe3D7, anon-EST:Liang-2.11, anon-EST:Liang-2.17, CALR, Calregulin, cC1qR, CG9429, clone 2.11, clone 2.17, Clr, crc, CRP55, CRT, Dmel\\CG9429, ERp60, eth, HACBP, NV19007, potp, RO, SSA, zgc:85636
list all proteins Gene Name GeneID UniProt
CALR 811 P27797
CALR 12317 P14211
CALR 64202 P18418

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Calreticulin Proteins (CALR) by Origin

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Top referenced Calreticulin Proteins

  1. Human Calreticulin Protein expressed in Escherichia coli (E. coli) - ABIN667783 : Kropp, Garg, Binder: Ovalbumin-derived precursor peptides are transferred sequentially from gp96 and calreticulin to MHC class I in the endoplasmic reticulum. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 2 references for ABIN667783

  2. Human Calreticulin Protein expressed in Human Cells - ABIN2005777 : Andrin, Pinkoski, Burns, Atkinson, Krahenbuhl, Hudig, Fraser, Winkler, Tschopp, Opas, Bleackley, Michalak: Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-cell granules. in Biochemistry 1998 (PubMed)

More Proteins for Calreticulin Interaction Partners

Fruit Fly (Drosophila melanogaster) Calreticulin (CALR) interaction partners

  1. Calreticulin plays a key role in olfactory system function, possibly by establishing its overall sensitivity to odorants.

  2. Calreticulin mediates hypersensitivity to diethylether and resistance to isoflurane in association with low expression of the gene.

  3. These results collectively indicate that calreticulin is the first molecule to be identified as a marker for phagocytosis of apoptotic cells by Drosophila phagocytes

Human Calreticulin (CALR) interaction partners

  1. Data show that the median calreticulin (CALR)mut (show MUT Proteins) allelic burden at diagnosis was significantly higher in primary myelofibrosis (PMF (show PRB1 Proteins)) patients as compared to essential thrombocythemia (ET) case.

  2. Studies indicate that a genetic classification of primary fibrosis (PMF (show PRB1 Proteins)) by calreticulin (CALR) and JAK2V617F (JAK2 (show JAK2 Proteins))mutations carried significant prognostic relevance.

  3. Mutation status of JAK2 (show JAK2 Proteins), CALR, and MPL (show MPL Proteins) in essential thrombocythemia and primary myelofibrosis defines clinical outcome.

  4. we show that the positive charge of the CALR mutant C-terminus is necessary to transform hematopoietic cells by enabling binding between mutant CALR and the thrombopoietin receptor MPL (show MPL Proteins).

  5. CALR is not only a potential diagnostic molecular marker but also adds relevant prognostic information as it is associated with milder clinical and haematological characteristics compared to the JAK2V617F-mutated or 'triple-negative' patients.

  6. The incidence of calreticulin mutations in essential thrombocythemia and primary myelofibrosis was 24.2% and increased to 50.0% in JAK2 (show JAK2 Proteins) V617F-negative cases. Essential thrombocythemia patients carrying calreti mutations were younger, showed lower WBC counts, and experienced less thrombosis than did those carrying the JAK2 (show JAK2 Proteins) V617F mutation, although no differences in other clinical features and prognosis were demonstrated.

  7. Anagrelide proved effective among all molecular subsets, indicating that JAK2 (show JAK2 Proteins)/CALR/MPL (show MPL Proteins) mutational status does not seem to represent a major determinant of choice of cytoreductive treatment among essential thrombocythemia therapies.

  8. This essential role of calreticulin in nucleocytoplasmic communication competency ties its regulatory action with proficiency of cardiac myofibrillogenesis essential for proper cardiac development.

  9. Evaluation of the role of JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) pathway in the oncogenic effect of calreticulin mutants in myeloproliferative neoplasms (review).

  10. Letter: CALR mutations are rare in Chinese Budd-Chiari syndrome patients.

Rabbit Calreticulin (CALR) interaction partners

  1. These findings suggest that protein kinase C is involved in the regulation of CRT function.

Mouse (Murine) Calreticulin (CALR) interaction partners

  1. This essential role of calreticulin in nucleocytoplasmic communication competency ties its regulatory action with proficiency of cardiac myofibrillogenesis essential for proper cardiac development.

  2. Study provides evidence that chronic stress activates calreticulin and might be one of the pathological mechanisms underlying the motor coordination and motor learning dysfunctions seen in social defeat mice.

  3. This study for the first time revealed that increased CRT (show SLC6A8 Proteins) inhibited Fas (show FAS Proteins)/FasL (show FASL Proteins)-mediated neuronal cell apoptosis during the early stage of ischemic stroke, suggesting it to be a potential protector activated soon after ischemia-reperfusion injury

  4. The findings highlight the importance of CALR in female reproduction and demonstrate that compromised CALR function leads to ovarian insufficiency and female infertility.

  5. Calreticulin mediates vascular smooth muscle cell responses to injury through the regulation of collagen deposition and neointima formation.

  6. CALR mutants are sufficient to induce thrombocytosis through MPL (show MPL Proteins) activation.

  7. Thrombopoietin receptor (show MPL Proteins) activation by myeloproliferative neoplasm associated calreticulin mutants.

  8. These studies reveal central roles for ATP and calcium binding as regulators of calreticulin-substrate interactions and as key determinants of PLC (show HSPG2 Proteins) dynamics.

  9. study demonstrates for the first time that LRH-1 (show NR5A2 Proteins) has a CRT (show SLC6A8 Proteins)-dependent NES (show NES Proteins) which is not only required for cytoplasmic trafficking, but also essential for correct protein folding to avoid misfolding-induced aggregation.

  10. Arginylated CRT has a longer half-life than non-arginylated CRT and displays different ubiquitin dependence.

Cow (Bovine) Calreticulin (CALR) interaction partners

  1. the lectin site of CRT is the main target for gentamicin binding

Pig (Porcine) Calreticulin (CALR) interaction partners

  1. Calreticulin is confined to subplasmalemmal vesicles partially overlapping with cortical granule contents. Its exocytosis after the oocyte activation seems to participate in the membrane block to polyspermy in pigs.

  2. Calreticulin was widely expressed in pig tissues and its transcripts were downregulated during maturation, especially at 44 hr, and were undetectable at the blastocyst stage.

Calreticulin (CALR) Protein Profile

Protein Summary

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.

Alternative names and synonyms associated with Calreticulin (CALR)

  • calreticulin (calr)
  • calreticulin (crt)
  • calreticulin (CRT)
  • Calreticulin (Crc)
  • calreticulin (LmjF31.2600)
  • calreticulin (Crc)
  • calreticulin (CALR)
  • calreticulin (Calr)
  • calreticulin (Crt)
  • calreticulin 2, calcium-binding protein (CRT2)
  • calreticulin 3 (CALR3)
  • anon-EST:fe3D7 protein
  • anon-EST:Liang-2.11 protein
  • anon-EST:Liang-2.17 protein
  • CALR protein
  • Calregulin protein
  • cC1qR protein
  • CG9429 protein
  • clone 2.11 protein
  • clone 2.17 protein
  • Clr protein
  • crc protein
  • CRP55 protein
  • CRT protein
  • Dmel\\CG9429 protein
  • ERp60 protein
  • eth protein
  • HACBP protein
  • NV19007 protein
  • potp protein
  • RO protein
  • SSA protein
  • zgc:85636 protein

Protein level used designations for Calreticulin Proteins (CALR)

calreticulin , CG9429-PA , CG9429-PB , Crc-PA , Crc-PB , anon-fast-evolving-3D7 , pot pourri , potpourri , ER-resident chaperone calreticulin , CRP55 , ERp60 , HACBP , Sicca syndrome antigen A (autoantigen Ro; calreticulin) , calregulin , endoplasmic reticulum resident protein 60 , grp60 , CABP3 , CALBP , calcium-binding protein 3 , calrectulin , Endoplasmic reticulum resident protein 60

379788 Xenopus laevis
100136202 Oncorhynchus mykiss
100146083 Triticum aestivum
30248 Danio rerio
41166 Drosophila melanogaster
407962 Xenopus (Silurana) tropicalis
5654192 Leishmania major strain Friedlin
100116123 Nasonia vitripennis
100304608 Ictalurus punctatus
811 Homo sapiens
476694 Canis lupus familiaris
100009050 Oryctolagus cuniculus
12317 Mus musculus
64202 Rattus norvegicus
281036 Bos taurus
100381266 Sus scrofa
101104396 Ovis aries
100713922 Cavia porcellus
692629 Bombyx mori
100689096 Cricetulus griseus
5715514 Chlamydomonas reinhardtii
420146 Gallus gallus
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