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Human EZH2 Protein expressed in Human - ABIN2720645
Pedram Fatemi, Salah-Uddin, Modarresi, Khoury, Wahlestedt, Faghihi: Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen. in Journal of biomolecular screening 2015
Show all 2 references for ABIN2720645
Human EZH2 Protein expressed in Wheat germ - ABIN1353283
Guil, Soler, Portela, Carrère, Fonalleras, Gómez, Villanueva, Esteller: Intronic RNAs mediate EZH2 regulation of epigenetic targets. in Nature structural & molecular biology 2012
Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.
exon-skipping event in Enhancer of Zeste Homologue 2 (EZH2) along with expression changes showed significant down regulation on Day 5 and Day 9 but returned to normal level on Day 13 and Day 17.
Authors investigated the expression and clinical implications of enhancer of Zeste homolog 2 (EZH2) in cervical squamous cell carcinoma (SCC (show CYP11A1 Proteins)) and precancerous lesions. The positive expression rate of EZH2 in SCC (show CYP11A1 Proteins) patients with and without lymph node metastasis was 82.9 and 70.4%.
this work shows that NIPP1 (show PPP1R8 Proteins)/EZH2 expression can be a reliable prognostic factor for hepatocellular carcinoma.
Hyperactivation of EZH2 by mutations or amplification drives epigenetic silencing of genes involved in tumor suppression and immune responses in cancer
These results suggested that miR (show MLXIP Proteins)-98 functioned as a potential tumor suppressor by regulating Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signal pathway through direct suppression of EZH2 expression and might sever as a potential therapeutic target for HCC (show FAM126A Proteins) patients.
EZH2 inhibits the expression of tumor suppressor gene RASSF2A via promoter hypermethylation. Thus, it plays an important role in tumorigenesis.
lncRNA PVT1 may contribute to tumorigenesis of thyroid cancer through recruiting EZH2 and regulating TSHR (show TSHR Proteins) expression.
western blotting results revealed that higher expression of EZH2 was related with lower level of Dicer (show DICER1 Proteins) in HeLa/DDP (show TIMM8A Proteins) cells. Finally, in vivo tumorigenicity experiments results demonstrated that interference with endogenous EZH2 by shRNA specific to EZH2 or inhibition EZH2 by DZNep could significantly increase antitumor effects in nude mice.
Long non-coding RNA SPRY4 (show SPRY4 Proteins)-IT1 (show HAUS3 Proteins) promotes tumor cell proliferation and invasion by activating EZH2 in hepatocellular carcinoma and epigenetically repressing E-cadherin (show CDH1 Proteins) expression.
EZH2 mediated hepatocellular carcinoma aggressiveness and epigenetically silenced CLDN14 (show CLDN14 Proteins).
Genetic inactivation of Ezh2 or Eed (show EED Proteins) cooperates with NRASQ61K in leukemogenesis.
Study demonstrated that redundant EZH2 shifted mesenchymal stem cell lineage commitment to adipocyte, which contributed to the development of osteoporosis.
Data indicate increased natural killer (NK) lineage cells in Ezh2 (enhancer of zeste homolog 2)-deficient mice.
Ezh2 cooperates with let-7 microRNAs in silencing the fetal gene signature in BM HSPCs and restricts their transformation.
Conditional deletion of Ezh2 in the developing midbrain resulted in decreased neural progenitor proliferation, which is associated with derepression of cell cycle inhibitors and negative regulation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
The dichotomous function of EZH2 in regulating differentiation and senescence in effector and regulatory T cells helps to explain the apparent existing contradictions in literature.
Modulation of Polycomb repressive complexes by either Ezh2 overexpression or Eed deletion enhances KRAS-driven adenomagenesis and inflammation
Study used Ezh2 conditional knockout mice to clarify the role of histone H3K27me3 modification in the retina
The presence of EZH2 is required to control progressive differentiation of milk secreting epithelium during pregnancy.
These results clearly demonstrated an essential role of Ezh1 (show EZH1 Proteins) in the pathogenesis of hematopoietic malignancies induced by Ezh2 insufficiency, and highlighted the differential functions of Ezh1 (show EZH1 Proteins) and Ezh2 in hematopoiesis.
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
enhancer of zeste 2
, enhancer of zeste homolog 2 (Drosophila)
, Polycomb protein EZH2
, histone-lysine N-methyltransferase EZH2
, histone-lysine N-methyltransferase EZH2-like
, Enhancer of zeste homolog 2-A
, Polycomb protein EZH2-A
, lysine N-methyltransferase 6
, enhancer of zeste homolog 2
, eyes absent homolog 2