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Browse our EZH2 Proteins (EZH2)

Full name:
Enhancer of Zeste Homolog 2 (Drosophila) Proteins (EZH2)
On are 8 Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) Proteins from 6 different suppliers available. Additionally we are shipping EZH2 Antibodies (228) and EZH2 Kits (21) and many more products for this protein. A total of 269 EZH2 products are currently listed.
Enx-1, ENX1, Enx1h, eya2, EZH1, ezh2, EZH2b, im:7149338, KMT6, KMT6A, mKIAA4065, olezh2, WVS, WVS2, xez, zgc:136376, zgc:152758
list all proteins Gene Name GeneID UniProt
EZH2 2146 Q15910
EZH2 14056 Q61188
Rat EZH2 EZH2 312299  

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EZH2 Proteins (EZH2) by Origin

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Top referenced EZH2 Proteins

  1. Human EZH2 Protein expressed in Human - ABIN2720645 : Pedram Fatemi, Salah-Uddin, Modarresi, Khoury, Wahlestedt, Faghihi: Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen. in Journal of biomolecular screening 2015 (PubMed)
    Show all 2 references for ABIN2720645

  2. Human EZH2 Protein expressed in Wheat germ - ABIN1353283 : Guil, Soler, Portela, Carrère, Fonalleras, Gómez, Villanueva, Esteller: Intronic RNAs mediate EZH2 regulation of epigenetic targets. in Nature structural & molecular biology 2012 (PubMed)

More Proteins for EZH2 Interaction Partners

Xenopus laevis Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) interaction partners

  1. Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.

Human Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) interaction partners

  1. the activated CDK5 (show CDK5 Proteins) kinase is involved in the EZH2 phosphorylation that is required for FBW7 (show FBXW7 Proteins)-mediated degradation.

  2. This perspective describes recent findings in pathogenic role of EZH2 in hematological malignancies. [review]

  3. EZH2 expression in NSCLC and adenocarcinoma may have a role in significantly poorer survival

  4. High EZH2 expression is associated with prostate cancer.

  5. These evidences suggest that EZH2 and EZH1 (show EZH1 Proteins) are important in the counter-balancing mechanisms controlling proliferation/resting of lymphoid cells. The disruption of the balanced EZH2/EZH1 ratio may play important roles in the pathogenesis of lymphomas

  6. Melatonin inhibits tumorigenicity of glioblastoma stem-like cells via the AKT (show AKT1 Proteins)-EZH2-STAT3 (show STAT3 Proteins) signaling axis.

  7. Data indicate that NFIB (show NFIB Proteins) protein increases EZH2 protein expression downstream of BRN2 (show POU3F2 Proteins) protein, which further decreases MITF (show MITF Proteins) protein levels.

  8. nuclear expression in a majority of the lymphoblasts from bone marrow clot (show TXNDC17 Proteins) preparations of each of the study cases for both silent mating type information regulation 2 homolog 1 (SIRT1 (show SIRT1 Proteins)), an NAD+ histone deacetylase (show HDAC1 Proteins) and enhancer of Zeste homolog 2 (EZH2), a histone methyltransferase.

  9. The results of Trans-well and cell scratch tests showed that when ANCR (show ube3a Proteins) expression was decreased, the invasion and migration abilities of SW620 cells significantly declined. In conclusion, these results suggest that lncRNA-ANCR (show ube3a Proteins) could influence the invasion and migration of CRC (show CALR Proteins) cells by specifically binding to EZH2.

  10. exon-skipping event in Enhancer of Zeste Homologue 2 (EZH2) along with expression changes showed significant down regulation on Day 5 and Day 9 but returned to normal level on Day 13 and Day 17.

Mouse (Murine) Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) interaction partners

  1. The Ezh2 expression could be clearly seen in outer and inner hair cells, supporting cells, the stria vascularis, and spiral ganglion cells. Ezh2 continued to be expressed in the cochlear epithelium of adult mice.

  2. Genetic inactivation of Ezh2 or Eed (show EED Proteins) cooperates with NRASQ61K in leukemogenesis.

  3. Study demonstrated that redundant EZH2 shifted mesenchymal stem cell lineage commitment to adipocyte, which contributed to the development of osteoporosis.

  4. Data indicate increased natural killer (NK) lineage cells in Ezh2 (enhancer of zeste homolog 2)-deficient mice.

  5. Ezh2 cooperates with let-7 microRNAs in silencing the fetal gene signature in BM HSPCs and restricts their transformation.

  6. Conditional deletion of Ezh2 in the developing midbrain resulted in decreased neural progenitor proliferation, which is associated with derepression of cell cycle inhibitors and negative regulation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  7. The dichotomous function of EZH2 in regulating differentiation and senescence in effector and regulatory T cells helps to explain the apparent existing contradictions in literature.

  8. Modulation of Polycomb repressive complexes by either Ezh2 overexpression or Eed deletion enhances KRAS-driven adenomagenesis and inflammation

  9. Study used Ezh2 conditional knockout mice to clarify the role of histone H3K27me3 modification in the retina

  10. The presence of EZH2 is required to control progressive differentiation of milk secreting epithelium during pregnancy.

EZH2 Protein Profile

Protein Summary

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.

Alternative names and synonyms associated with EZH2

  • enhancer of zeste homolog 2 (Drosophila) (EZH2)
  • enhancer of zeste homolog 2 (ezh2)
  • enhancer of zeste homolog 2 (ezh2-a)
  • enhancer of zeste homolog 2 (Drosophila) (Ezh2)
  • enhancer of zeste homolog 2 (Drosophila) (ezh2)
  • Enx-1 protein
  • ENX1 protein
  • Enx1h protein
  • eya2 protein
  • EZH1 protein
  • ezh2 protein
  • EZH2b protein
  • im:7149338 protein
  • KMT6 protein
  • KMT6A protein
  • mKIAA4065 protein
  • olezh2 protein
  • WVS protein
  • WVS2 protein
  • xez protein
  • zgc:136376 protein
  • zgc:152758 protein

Protein level used designations for EZH2

enhancer of zeste 2 , enhancer of zeste homolog 2 (Drosophila) , Polycomb protein EZH2 , histone-lysine N-methyltransferase EZH2 , histone-lysine N-methyltransferase EZH2-like , Enhancer of zeste homolog 2-A , Polycomb protein EZH2-A , lysine N-methyltransferase 6 , enhancer of zeste homolog 2 , eyes absent homolog 2

745437 Pan troglodytes
100051290 Equus caballus
550047 Xenopus (Silurana) tropicalis
709075 Macaca mulatta
100125823 Oryzias latipes
100394758 Callithrix jacchus
100447447 Pongo abelii
100540374 Meleagris gallopavo
100580962 Nomascus leucogenys
399174 Xenopus laevis
2146 Homo sapiens
14056 Mus musculus
420784 Gallus gallus
475511 Canis lupus familiaris
100625497 Sus scrofa
509106 Bos taurus
312299 Rattus norvegicus
768133 Danio rerio
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