You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our EZH2 Proteins (EZH2)

Full name:
Enhancer of Zeste Homolog 2 (Drosophila) Proteins (EZH2)
On are 8 Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) Proteins from 6 different suppliers available. Additionally we are shipping EZH2 Antibodies (225) and EZH2 Kits (19) and many more products for this protein. A total of 264 EZH2 products are currently listed.
Enx-1, ENX1, Enx1h, eya2, EZH1, ezh2, EZH2b, im:7149338, KMT6, KMT6A, mKIAA4065, olezh2, WVS, WVS2, xez, zgc:136376, zgc:152758
list all proteins Gene Name GeneID UniProt
EZH2 2146 Q15910
EZH2 14056 Q61188
Rat EZH2 EZH2 312299  

Show all synonyms

EZH2 Proteins (EZH2) by Origin

Select your origin of interest

Top referenced EZH2 Proteins

  1. Human EZH2 Protein expressed in Human - ABIN2720645 : Pedram Fatemi, Salah-Uddin, Modarresi, Khoury, Wahlestedt, Faghihi: Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen. in Journal of biomolecular screening 2015 (PubMed)
    Show all 2 references for ABIN2720645

  2. Human EZH2 Protein expressed in Wheat germ - ABIN1353283 : Guil, Soler, Portela, Carrère, Fonalleras, Gómez, Villanueva, Esteller: Intronic RNAs mediate EZH2 regulation of epigenetic targets. in Nature structural & molecular biology 2012 (PubMed)

More Proteins for EZH2 Interaction Partners

Xenopus laevis Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) interaction partners

  1. Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.

Human Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) interaction partners

  1. exon-skipping event in Enhancer of Zeste Homologue 2 (EZH2) along with expression changes showed significant down regulation on Day 5 and Day 9 but returned to normal level on Day 13 and Day 17.

  2. Authors investigated the expression and clinical implications of enhancer of Zeste homolog 2 (EZH2) in cervical squamous cell carcinoma (SCC (show CYP11A1 Proteins)) and precancerous lesions. The positive expression rate of EZH2 in SCC (show CYP11A1 Proteins) patients with and without lymph node metastasis was 82.9 and 70.4%.

  3. this work shows that NIPP1 (show PPP1R8 Proteins)/EZH2 expression can be a reliable prognostic factor for hepatocellular carcinoma.

  4. Hyperactivation of EZH2 by mutations or amplification drives epigenetic silencing of genes involved in tumor suppression and immune responses in cancer

  5. These results suggested that miR (show MLXIP Proteins)-98 functioned as a potential tumor suppressor by regulating Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signal pathway through direct suppression of EZH2 expression and might sever as a potential therapeutic target for HCC (show FAM126A Proteins) patients.

  6. EZH2 inhibits the expression of tumor suppressor gene RASSF2A via promoter hypermethylation. Thus, it plays an important role in tumorigenesis.

  7. lncRNA PVT1 may contribute to tumorigenesis of thyroid cancer through recruiting EZH2 and regulating TSHR (show TSHR Proteins) expression.

  8. western blotting results revealed that higher expression of EZH2 was related with lower level of Dicer (show DICER1 Proteins) in HeLa/DDP (show TIMM8A Proteins) cells. Finally, in vivo tumorigenicity experiments results demonstrated that interference with endogenous EZH2 by shRNA specific to EZH2 or inhibition EZH2 by DZNep could significantly increase antitumor effects in nude mice.

  9. Long non-coding RNA SPRY4 (show SPRY4 Proteins)-IT1 (show HAUS3 Proteins) promotes tumor cell proliferation and invasion by activating EZH2 in hepatocellular carcinoma and epigenetically repressing E-cadherin (show CDH1 Proteins) expression.

  10. EZH2 mediated hepatocellular carcinoma aggressiveness and epigenetically silenced CLDN14 (show CLDN14 Proteins).

Mouse (Murine) Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) interaction partners

  1. Genetic inactivation of Ezh2 or Eed (show EED Proteins) cooperates with NRASQ61K in leukemogenesis.

  2. Study demonstrated that redundant EZH2 shifted mesenchymal stem cell lineage commitment to adipocyte, which contributed to the development of osteoporosis.

  3. Data indicate increased natural killer (NK) lineage cells in Ezh2 (enhancer of zeste homolog 2)-deficient mice.

  4. Ezh2 cooperates with let-7 microRNAs in silencing the fetal gene signature in BM HSPCs and restricts their transformation.

  5. Conditional deletion of Ezh2 in the developing midbrain resulted in decreased neural progenitor proliferation, which is associated with derepression of cell cycle inhibitors and negative regulation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  6. The dichotomous function of EZH2 in regulating differentiation and senescence in effector and regulatory T cells helps to explain the apparent existing contradictions in literature.

  7. Modulation of Polycomb repressive complexes by either Ezh2 overexpression or Eed deletion enhances KRAS-driven adenomagenesis and inflammation

  8. Study used Ezh2 conditional knockout mice to clarify the role of histone H3K27me3 modification in the retina

  9. The presence of EZH2 is required to control progressive differentiation of milk secreting epithelium during pregnancy.

  10. These results clearly demonstrated an essential role of Ezh1 (show EZH1 Proteins) in the pathogenesis of hematopoietic malignancies induced by Ezh2 insufficiency, and highlighted the differential functions of Ezh1 (show EZH1 Proteins) and Ezh2 in hematopoiesis.

EZH2 Protein Profile

Protein Summary

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.

Alternative names and synonyms associated with EZH2

  • enhancer of zeste homolog 2 (Drosophila) (EZH2)
  • enhancer of zeste homolog 2 (ezh2)
  • enhancer of zeste homolog 2 (ezh2-a)
  • enhancer of zeste homolog 2 (Drosophila) (Ezh2)
  • enhancer of zeste homolog 2 (Drosophila) (ezh2)
  • Enx-1 protein
  • ENX1 protein
  • Enx1h protein
  • eya2 protein
  • EZH1 protein
  • ezh2 protein
  • EZH2b protein
  • im:7149338 protein
  • KMT6 protein
  • KMT6A protein
  • mKIAA4065 protein
  • olezh2 protein
  • WVS protein
  • WVS2 protein
  • xez protein
  • zgc:136376 protein
  • zgc:152758 protein

Protein level used designations for EZH2

enhancer of zeste 2 , enhancer of zeste homolog 2 (Drosophila) , Polycomb protein EZH2 , histone-lysine N-methyltransferase EZH2 , histone-lysine N-methyltransferase EZH2-like , Enhancer of zeste homolog 2-A , Polycomb protein EZH2-A , lysine N-methyltransferase 6 , enhancer of zeste homolog 2 , eyes absent homolog 2

745437 Pan troglodytes
100051290 Equus caballus
550047 Xenopus (Silurana) tropicalis
709075 Macaca mulatta
100125823 Oryzias latipes
100394758 Callithrix jacchus
100447447 Pongo abelii
100540374 Meleagris gallopavo
100580962 Nomascus leucogenys
399174 Xenopus laevis
2146 Homo sapiens
14056 Mus musculus
420784 Gallus gallus
475511 Canis lupus familiaris
100625497 Sus scrofa
509106 Bos taurus
312299 Rattus norvegicus
768133 Danio rerio
Selected quality suppliers for EZH2 Proteins (EZH2)
Did you look for something else?