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Human EZH2 Protein expressed in HEK-293 Cells - ABIN2720645
Pedram Fatemi, Salah-Uddin, Modarresi, Khoury, Wahlestedt, Faghihi: Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen. in Journal of biomolecular screening 2015
Show all 2 references for ABIN2720645
Human EZH2 Protein expressed in Wheat germ - ABIN1353283
Guil, Soler, Portela, Carrère, Fonalleras, Gómez, Villanueva, Esteller: Intronic RNAs mediate EZH2 regulation of epigenetic targets. in Nature structural & molecular biology 2012
Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.
EZH2 and ZFX genes do not seem to have an impact on the onset of most parathyroid tumours, both benign and malignant, though further studies on larger cohorts of different ethnicity are needed.
BRD4 (show BRD4 Proteins) positively regulates EZH2 transcription through upregulation of C-MYC (show MYC Proteins), and is a novel promising target for pharmacologic treatment in transcriptional program intervention against this intractable disease.
findings suggest that EZH2 possesses anti-apoptotic activity in gastric tumorigenesis following STAT3 (show STAT3 Proteins) activation
Inhibition of EZH2 (by GSK-343 or EPZ-6438) or inhibition of EHMT2 (show EHMT2 Proteins) (by UNC-0638) in the Th17 primary cell model of HIV latency or resting memory T cells isolated from HIV-1-infected patients receiving highly active antiretroviral therapy, was sufficient to induce the reactivation of latent proviruses.
Data indicate that enhancer of zeste homolog 2 (Drosophila) protein (EZH2) is a direct target of microRNA miR (show MLXIP Proteins)-126 and restoration of EZH2 expression blocks the suppressive roles of miR (show MLXIP Proteins)-126.
the functional association between EZH2 expression and silencing of key tumor suppressor loci , was investigated.
H19 (show NCKAP1 Proteins) inhibited E-cadherin (show CDH1 Proteins) expression and promoted cell invasion of NPC (show NPC1 Proteins) cells via the miR (show MLXIP Proteins)-630/EZH2 pathway
We also showed that knockdown of urothelial carcinoma-associated 1 increased the p21 protein (show NRAS Proteins) expression through regulating enhancer of zeste homolog 2. In addition, bioinformatics analysis and dual-luciferase reporter assays confirmed that miR (show MLXIP Proteins)-495 was a target of urothelial carcinoma-associated 1 in renal cell carcinoma (show MOK Proteins), and urothelial carcinoma-associated 1 promoted cell proliferation by negatively regulating miR (show MLXIP Proteins)-495
EZH2, through a methyltransferase-independent mechanism, promotes the transcriptional activation of the non-canonical NF-kappaB (show NFKB1 Proteins) subunit RelB (show RELB Proteins)
enhancer of zeste homolog 2 (EZH2) accounts for the silence of 11beta-HSD2 (show HSD11B2 Proteins) expression via trimethylation of histone H3 (show HIST3H3 Proteins) lysine 27 at the promoter of the 11beta-HSD2 (show HSD11B2 Proteins) gene.
Menin (show MEN1 Proteins) binds on the promoter of Inhbb (show INHBB Proteins) gene where it favours the recruitment of Ezh2 via an indirect mechanism involving Akt (show AKT1 Proteins)-phosphorylation.
EZH2 directly interacted with and stabilized BubR1 (show BUB1B Proteins), an effect driving EZH2 into the concert of meiosis regulation.
A long noncoding RNA, lnc-beta-Catm, elicits EZH2-dependent beta-catenin (show CTNNB1 Proteins) stabilization and sustains liver cancer stem cells self-renewal.
these results suggest that the inflammatory milieu found in Crohn's disease could lead to or result from deregulation of FOXP3 (show FOXP3 Proteins)/EZH2-enforced T cell gene networks contributing to the underlying intestinal inflammation.
Data show that enhancer of zeste 2 polycomb (show CBX2 Proteins) repressive complex 2 subunit (EZH2-containing PRC2) is required for differentiation of terminal effector CD8 (show CD8A Proteins)+ T cells.
these data suggest that inhibition of Ezh2 promotes paracrine signaling in osteoblasts a
demonstrate that a specific interaction between the polycomb protein EZH2 and RNA made from B2 SINE retrotransposons controls stress-responsive genes in mouse cells. In the heat-shock model, B2 RNA binds stress genes and suppresses their transcription. Upon stress, EZH2 is recruited and triggers cleavage of B2 RNA. B2 degradation in turn upregulates stress genes.
The Ezh2 expression could be clearly seen in outer and inner hair cells, supporting cells, the stria vascularis, and spiral ganglion cells. Ezh2 continued to be expressed in the cochlear epithelium of adult mice.
Genetic inactivation of Ezh2 or Eed (show EED Proteins) cooperates with NRASQ61K in leukemogenesis.
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
enhancer of zeste 2
, enhancer of zeste homolog 2 (Drosophila)
, Polycomb protein EZH2
, histone-lysine N-methyltransferase EZH2
, histone-lysine N-methyltransferase EZH2-like
, Enhancer of zeste homolog 2-A
, Polycomb protein EZH2-A
, lysine N-methyltransferase 6
, enhancer of zeste homolog 2
, eyes absent homolog 2