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Browse our EZH2 Proteins (EZH2)

Full name:
Enhancer of Zeste Homolog 2 (Drosophila) Proteins (EZH2)
On are 8 Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) Proteins from 6 different suppliers available. Additionally we are shipping EZH2 Antibodies (225) and EZH2 Kits (22) and many more products for this protein. A total of 267 EZH2 products are currently listed.
Enx-1, ENX1, Enx1h, eya2, EZH1, ezh2, EZH2b, im:7149338, KMT6, KMT6A, mKIAA4065, olezh2, WVS, WVS2, xez, zgc:136376, zgc:152758
list all proteins Gene Name GeneID UniProt
EZH2 2146 Q15910
EZH2 14056 Q61188
Rat EZH2 EZH2 312299  

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EZH2 Proteins (EZH2) by Origin

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Top referenced EZH2 Proteins

  1. Human EZH2 Protein expressed in HEK-293 Cells - ABIN2720645 : Pedram Fatemi, Salah-Uddin, Modarresi, Khoury, Wahlestedt, Faghihi: Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen. in Journal of biomolecular screening 2015 (PubMed)
    Show all 2 references for ABIN2720645

  2. Human EZH2 Protein expressed in Wheat germ - ABIN1353283 : Guil, Soler, Portela, Carrère, Fonalleras, Gómez, Villanueva, Esteller: Intronic RNAs mediate EZH2 regulation of epigenetic targets. in Nature structural & molecular biology 2012 (PubMed)

More Proteins for EZH2 Interaction Partners

Xenopus laevis Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) interaction partners

  1. Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.

Human Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) interaction partners

  1. EZH2 and ZFX genes do not seem to have an impact on the onset of most parathyroid tumours, both benign and malignant, though further studies on larger cohorts of different ethnicity are needed.

  2. BRD4 (show BRD4 Proteins) positively regulates EZH2 transcription through upregulation of C-MYC (show MYC Proteins), and is a novel promising target for pharmacologic treatment in transcriptional program intervention against this intractable disease.

  3. findings suggest that EZH2 possesses anti-apoptotic activity in gastric tumorigenesis following STAT3 (show STAT3 Proteins) activation

  4. Inhibition of EZH2 (by GSK-343 or EPZ-6438) or inhibition of EHMT2 (show EHMT2 Proteins) (by UNC-0638) in the Th17 primary cell model of HIV latency or resting memory T cells isolated from HIV-1-infected patients receiving highly active antiretroviral therapy, was sufficient to induce the reactivation of latent proviruses.

  5. Data indicate that enhancer of zeste homolog 2 (Drosophila) protein (EZH2) is a direct target of microRNA miR (show MLXIP Proteins)-126 and restoration of EZH2 expression blocks the suppressive roles of miR (show MLXIP Proteins)-126.

  6. the functional association between EZH2 expression and silencing of key tumor suppressor loci , was investigated.

  7. H19 (show NCKAP1 Proteins) inhibited E-cadherin (show CDH1 Proteins) expression and promoted cell invasion of NPC (show NPC1 Proteins) cells via the miR (show MLXIP Proteins)-630/EZH2 pathway

  8. We also showed that knockdown of urothelial carcinoma-associated 1 increased the p21 protein (show NRAS Proteins) expression through regulating enhancer of zeste homolog 2. In addition, bioinformatics analysis and dual-luciferase reporter assays confirmed that miR (show MLXIP Proteins)-495 was a target of urothelial carcinoma-associated 1 in renal cell carcinoma (show MOK Proteins), and urothelial carcinoma-associated 1 promoted cell proliferation by negatively regulating miR (show MLXIP Proteins)-495

  9. EZH2, through a methyltransferase-independent mechanism, promotes the transcriptional activation of the non-canonical NF-kappaB (show NFKB1 Proteins) subunit RelB (show RELB Proteins)

  10. enhancer of zeste homolog 2 (EZH2) accounts for the silence of 11beta-HSD2 (show HSD11B2 Proteins) expression via trimethylation of histone H3 (show HIST3H3 Proteins) lysine 27 at the promoter of the 11beta-HSD2 (show HSD11B2 Proteins) gene.

Mouse (Murine) Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) interaction partners

  1. the functional association between EZH2 expression and silencing of key tumor suppressor loci , was investigated.

  2. Menin (show MEN1 Proteins) binds on the promoter of Inhbb (show INHBB Proteins) gene where it favours the recruitment of Ezh2 via an indirect mechanism involving Akt (show AKT1 Proteins)-phosphorylation.

  3. EZH2 directly interacted with and stabilized BubR1 (show BUB1B Proteins), an effect driving EZH2 into the concert of meiosis regulation.

  4. A long noncoding RNA, lnc-beta-Catm, elicits EZH2-dependent beta-catenin (show CTNNB1 Proteins) stabilization and sustains liver cancer stem cells self-renewal.

  5. these results suggest that the inflammatory milieu found in Crohn's disease could lead to or result from deregulation of FOXP3 (show FOXP3 Proteins)/EZH2-enforced T cell gene networks contributing to the underlying intestinal inflammation.

  6. Data show that enhancer of zeste 2 polycomb (show CBX2 Proteins) repressive complex 2 subunit (EZH2-containing PRC2) is required for differentiation of terminal effector CD8 (show CD8A Proteins)+ T cells.

  7. these data suggest that inhibition of Ezh2 promotes paracrine signaling in osteoblasts a

  8. demonstrate that a specific interaction between the polycomb protein EZH2 and RNA made from B2 SINE retrotransposons controls stress-responsive genes in mouse cells. In the heat-shock model, B2 RNA binds stress genes and suppresses their transcription. Upon stress, EZH2 is recruited and triggers cleavage of B2 RNA. B2 degradation in turn upregulates stress genes.

  9. The Ezh2 expression could be clearly seen in outer and inner hair cells, supporting cells, the stria vascularis, and spiral ganglion cells. Ezh2 continued to be expressed in the cochlear epithelium of adult mice.

  10. Genetic inactivation of Ezh2 or Eed (show EED Proteins) cooperates with NRASQ61K in leukemogenesis.

EZH2 Protein Profile

Protein Summary

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.

Alternative names and synonyms associated with EZH2

  • enhancer of zeste homolog 2 (Drosophila) (EZH2)
  • enhancer of zeste homolog 2 (ezh2)
  • enhancer of zeste homolog 2 (ezh2-a)
  • enhancer of zeste homolog 2 (Drosophila) (Ezh2)
  • enhancer of zeste homolog 2 (Drosophila) (ezh2)
  • Enx-1 protein
  • ENX1 protein
  • Enx1h protein
  • eya2 protein
  • EZH1 protein
  • ezh2 protein
  • EZH2b protein
  • im:7149338 protein
  • KMT6 protein
  • KMT6A protein
  • mKIAA4065 protein
  • olezh2 protein
  • WVS protein
  • WVS2 protein
  • xez protein
  • zgc:136376 protein
  • zgc:152758 protein

Protein level used designations for EZH2

enhancer of zeste 2 , enhancer of zeste homolog 2 (Drosophila) , Polycomb protein EZH2 , histone-lysine N-methyltransferase EZH2 , histone-lysine N-methyltransferase EZH2-like , Enhancer of zeste homolog 2-A , Polycomb protein EZH2-A , lysine N-methyltransferase 6 , enhancer of zeste homolog 2 , eyes absent homolog 2

745437 Pan troglodytes
100051290 Equus caballus
550047 Xenopus (Silurana) tropicalis
709075 Macaca mulatta
100125823 Oryzias latipes
100394758 Callithrix jacchus
100447447 Pongo abelii
100540374 Meleagris gallopavo
100580962 Nomascus leucogenys
399174 Xenopus laevis
2146 Homo sapiens
14056 Mus musculus
420784 Gallus gallus
475511 Canis lupus familiaris
100625497 Sus scrofa
509106 Bos taurus
312299 Rattus norvegicus
768133 Danio rerio
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