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Human EZH2 Protein expressed in Wheat germ - ABIN1353283
Guil, Soler, Portela, Carrère, Fonalleras, Gómez, Villanueva, Esteller: Intronic RNAs mediate EZH2 regulation of epigenetic targets. in Nature structural & molecular biology 2012
Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.
EZH2 overexpression is associated aggressive pathologic features including high nuclear grade, high proliferative index, and positivity of HER2 (show ERBB2 Proteins) of breast carcinoma.
Ectopic expression of EZH2 inhibited the transcriptional activities of miR (show MLXIP Proteins)-101-1 promoter. Subsequent analyses revealed that miR (show MLXIP Proteins)-101-1 directly represses the expression of EZH2, and miR (show MLXIP Proteins)-101-1 and EZH2 form a reciprocal negative feedback loop.
Data show that long non-coding RNA MALAT1 may be a crucial RNA cofactor of Polycomb (show CBX2 Proteins) protein enhancer of zeste homolog 2 (EZH2) and that may provide a new avenue for development new strategies for treatment of castration-resistant prostate cancer (CRPC).
Data show a mutual suppression regulation between chromodomain helicase DNA binding protein 5 (CHD5) and enhancer of zeste homolog 2 (EZH2, which may provide new insights into their potential therapeutic significance for hepatocellular carcinoma (HCC (show FAM126A Proteins)).
Data show that increased polycomb (show CBX2 Proteins) repressive complex 2 EZH2 and/or polycomb (show CBX2 Proteins) repressive complex 1 BMI1 (show BMI1 Proteins) expression repress the expression of microRNA miR (show MLXIP Proteins)-200 family members.
Fluid shear stress decreases the expression of the Polycomb (show CBX2 Proteins) methyltransferase EZH2.
study provides evidence that epigenetic regulation of Reelin (show RELN Proteins) by Ezh2 maintains appropriate Reelin (show RELN Proteins) expression pattern to fulfill proper orientation of migrating neurons
Data show that basal-like subgroup was enriched for aggressive tumors and somatic mutations in trithorax (show MLLT1 Proteins)-group genes and it overexpressed polycomb (show CBX2 Proteins) genes EZH2 and CBX2 (show CBX2 Proteins).
The miR (show MLXIP Proteins)-335 expression was inversely correlated with Sox4 expression in the identical clinical specimens, but it was not related to the prognosis. Sox4/Ezh2 axis was closely associated with the prognosis in pancreatic cancer patients
EZH2 is highly expressed in pituitary adenomas, positively associated with Ki-67 (show MKI67 Proteins) expression, and associated with proliferation.
Data indicate increased natural killer (NK) lineage cells in Ezh2 (enhancer of zeste homolog 2)-deficient mice.
Ezh2 cooperates with let-7 microRNAs in silencing the fetal gene signature in BM HSPCs and restricts their transformation.
Conditional deletion of Ezh2 in the developing midbrain resulted in decreased neural progenitor proliferation, which is associated with derepression of cell cycle inhibitors and negative regulation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
The dichotomous function of EZH2 in regulating differentiation and senescence in effector and regulatory T cells helps to explain the apparent existing contradictions in literature.
Modulation of Polycomb repressive complexes by either Ezh2 overexpression or Eed deletion enhances KRAS-driven adenomagenesis and inflammation
Study used Ezh2 conditional knockout mice to clarify the role of histone H3K27me3 modification in the retina
The presence of EZH2 is required to control progressive differentiation of milk secreting epithelium during pregnancy.
These results clearly demonstrated an essential role of Ezh1 (show EZH1 Proteins) in the pathogenesis of hematopoietic malignancies induced by Ezh2 insufficiency, and highlighted the differential functions of Ezh1 (show EZH1 Proteins) and Ezh2 in hematopoiesis.
Results show that EZH2 promotes mammary stem and luminal progenitor cell expansion, metastasis and inhibits ER-positive cellular differentiation.
The study characterized the binding position of Ezh2 and menin (show MEN1 Proteins) at all annotated genes in embryonic stem cells and B and T lymphocytes.
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
enhancer of zeste 2
, enhancer of zeste homolog 2 (Drosophila)
, Polycomb protein EZH2
, histone-lysine N-methyltransferase EZH2
, histone-lysine N-methyltransferase EZH2-like
, Enhancer of zeste homolog 2-A
, Polycomb protein EZH2-A
, lysine N-methyltransferase 6
, enhancer of zeste homolog 2
, eyes absent homolog 2