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Browse our EZH2 Proteins (EZH2)

Full name:
Enhancer of Zeste Homolog 2 (Drosophila) Proteins (EZH2)
On are 8 Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) Proteins from 6 different suppliers available. Additionally we are shipping EZH2 Antibodies (220) and EZH2 Kits (27) and many more products for this protein. A total of 267 EZH2 products are currently listed.
Enx-1, ENX1, Enx1h, eya2, EZH1, ezh2, EZH2b, im:7149338, KMT6, KMT6A, mKIAA4065, olezh2, WVS, WVS2, xez, zgc:136376, zgc:152758
list all proteins Gene Name GeneID UniProt
EZH2 2146 Q15910
EZH2 14056 Q61188
Rat EZH2 EZH2 312299  

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EZH2 Proteins (EZH2) by Origin

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Top referenced EZH2 Proteins

  1. Human EZH2 Protein expressed in Wheat germ - ABIN1353283 : Guil, Soler, Portela, Carrère, Fonalleras, Gómez, Villanueva, Esteller: Intronic RNAs mediate EZH2 regulation of epigenetic targets. in Nature structural & molecular biology 2012 (PubMed)

More Proteins for EZH2 Interaction Partners

Xenopus laevis Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) interaction partners

  1. Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.

Human Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) interaction partners

  1. High EZH2 expression was significantly associated with different types of breast cancer.

  2. Data indicate that microRNA miR (show MLXIP Proteins)-26a regulated epithelial-mesenchymal transition (EMT (show ITK Proteins)) by targeting enhancer of zeste homolog 2 (EZH2).

  3. EZH2 overexpression is associated aggressive pathologic features including high nuclear grade, high proliferative index, and positivity of HER2 (show ERBB2 Proteins) of breast carcinoma.

  4. Ectopic expression of EZH2 inhibited the transcriptional activities of miR (show MLXIP Proteins)-101-1 promoter. Subsequent analyses revealed that miR (show MLXIP Proteins)-101-1 directly represses the expression of EZH2, and miR (show MLXIP Proteins)-101-1 and EZH2 form a reciprocal negative feedback loop.

  5. Data show that long non-coding RNA MALAT1 may be a crucial RNA cofactor of Polycomb (show CBX2 Proteins) protein enhancer of zeste homolog 2 (EZH2) and that may provide a new avenue for development new strategies for treatment of castration-resistant prostate cancer (CRPC).

  6. Data show a mutual suppression regulation between chromodomain helicase DNA binding protein 5 (CHD5) and enhancer of zeste homolog 2 (EZH2, which may provide new insights into their potential therapeutic significance for hepatocellular carcinoma (HCC (show FAM126A Proteins)).

  7. Data show that increased polycomb (show CBX2 Proteins) repressive complex 2 EZH2 and/or polycomb (show CBX2 Proteins) repressive complex 1 BMI1 (show BMI1 Proteins) expression repress the expression of microRNA miR (show MLXIP Proteins)-200 family members.

  8. Fluid shear stress decreases the expression of the Polycomb (show CBX2 Proteins) methyltransferase EZH2.

  9. study provides evidence that epigenetic regulation of Reelin (show RELN Proteins) by Ezh2 maintains appropriate Reelin (show RELN Proteins) expression pattern to fulfill proper orientation of migrating neurons

  10. Data show that basal-like subgroup was enriched for aggressive tumors and somatic mutations in trithorax (show MLLT1 Proteins)-group genes and it overexpressed polycomb (show CBX2 Proteins) genes EZH2 and CBX2 (show CBX2 Proteins).

Mouse (Murine) Enhancer of Zeste Homolog 2 (Drosophila) (EZH2) interaction partners

  1. Data indicate increased natural killer (NK) lineage cells in Ezh2 (enhancer of zeste homolog 2)-deficient mice.

  2. Ezh2 cooperates with let-7 microRNAs in silencing the fetal gene signature in BM HSPCs and restricts their transformation.

  3. Conditional deletion of Ezh2 in the developing midbrain resulted in decreased neural progenitor proliferation, which is associated with derepression of cell cycle inhibitors and negative regulation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  4. The dichotomous function of EZH2 in regulating differentiation and senescence in effector and regulatory T cells helps to explain the apparent existing contradictions in literature.

  5. Modulation of Polycomb repressive complexes by either Ezh2 overexpression or Eed deletion enhances KRAS-driven adenomagenesis and inflammation

  6. Study used Ezh2 conditional knockout mice to clarify the role of histone H3K27me3 modification in the retina

  7. The presence of EZH2 is required to control progressive differentiation of milk secreting epithelium during pregnancy.

  8. These results clearly demonstrated an essential role of Ezh1 (show EZH1 Proteins) in the pathogenesis of hematopoietic malignancies induced by Ezh2 insufficiency, and highlighted the differential functions of Ezh1 (show EZH1 Proteins) and Ezh2 in hematopoiesis.

  9. Results show that EZH2 promotes mammary stem and luminal progenitor cell expansion, metastasis and inhibits ER-positive cellular differentiation.

  10. The study characterized the binding position of Ezh2 and menin (show MEN1 Proteins) at all annotated genes in embryonic stem cells and B and T lymphocytes.

EZH2 Protein Profile

Protein Summary

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.

Alternative names and synonyms associated with EZH2

  • enhancer of zeste homolog 2 (Drosophila) (EZH2)
  • enhancer of zeste homolog 2 (ezh2)
  • enhancer of zeste homolog 2 (ezh2-a)
  • enhancer of zeste homolog 2 (Drosophila) (Ezh2)
  • enhancer of zeste homolog 2 (Drosophila) (ezh2)
  • Enx-1 protein
  • ENX1 protein
  • Enx1h protein
  • eya2 protein
  • EZH1 protein
  • ezh2 protein
  • EZH2b protein
  • im:7149338 protein
  • KMT6 protein
  • KMT6A protein
  • mKIAA4065 protein
  • olezh2 protein
  • WVS protein
  • WVS2 protein
  • xez protein
  • zgc:136376 protein
  • zgc:152758 protein

Protein level used designations for EZH2

enhancer of zeste 2 , enhancer of zeste homolog 2 (Drosophila) , Polycomb protein EZH2 , histone-lysine N-methyltransferase EZH2 , histone-lysine N-methyltransferase EZH2-like , Enhancer of zeste homolog 2-A , Polycomb protein EZH2-A , lysine N-methyltransferase 6 , enhancer of zeste homolog 2 , eyes absent homolog 2

745437 Pan troglodytes
100051290 Equus caballus
550047 Xenopus (Silurana) tropicalis
709075 Macaca mulatta
100125823 Oryzias latipes
100394758 Callithrix jacchus
100447447 Pongo abelii
100540374 Meleagris gallopavo
100580962 Nomascus leucogenys
399174 Xenopus laevis
2146 Homo sapiens
14056 Mus musculus
420784 Gallus gallus
475511 Canis lupus familiaris
100625497 Sus scrofa
509106 Bos taurus
312299 Rattus norvegicus
768133 Danio rerio
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