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Browse our TGIF1 Proteins (TGIF1)

Full name:
TGFB-Induced Factor Homeobox 1 Proteins (TGIF1)
On www.antibodies-online.com are 12 TGFB-Induced Factor Homeobox 1 (TGIF1) Proteins from 4 different suppliers available. Additionally we are shipping TGIF1 Antibodies (70) and many more products for this protein. A total of 92 TGIF1 products are currently listed.
Synonyms:
AA959811, AI462167, fa06h05, fb33g11, HPE4, Tfig, TGIF, tgif1, wu:fa06h05, wu:fb33g11, zgc:55852
list all proteins Gene Name GeneID UniProt
TGIF1 7050 Q15583
TGIF1 21815 P70284
Rat TGIF1 TGIF1 316742  

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TGIF1 Proteins (TGIF1) by Origin

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More Proteins for TGIF1 Interaction Partners

Zebrafish TGFB-Induced Factor Homeobox 1 (TGIF1) interaction partners

  1. Tgif1 expression and regulation of TGFbeta (show TGFB1 Proteins) signaling are implicated in the function of several types of stem cells, but this is the first demonstration that this regulatory network is necessary for regeneration of neurons.

  2. Tgif is necessary for normal initiation of genes that control RA synthesis and degradation, resulting in defects in RA-dependent central nervous system patterning in Tgif-depleted embryos.

Human TGFB-Induced Factor Homeobox 1 (TGIF1) interaction partners

  1. we suggest that TGIF (show IL10 Proteins) plays an important role in low-dose arsenic-induced malignant transformation of HaCaT cells, which is regulated by c-Src (show SRC Proteins)/EGFR (show EGFR Proteins)/AKT (show AKT1 Proteins)/FOXO3A (show FOXO3 Proteins) pathway and redox signaling.

  2. Corneal fibroblasts demonstrate the expression of TGIF1 and TGIF2 (show TGIF2 Proteins) transcription factors. These transcriptional repressors are critical, at least partially, in mediating the antifibrotic effect of vorinostat in the cornea.

  3. Our results suggested that elevated expression of TGIF (show IL10 Proteins) was involved in lung carcinogenesis.

  4. our study demonstrated the oncogenic role of TGIF1 in NSCLC, and TGIF1 might be a therapeutic target for non-small cell lung cancer .

  5. c-Src (show SRC Proteins)/AKT (show AKT1 Proteins) is the upstream signaling that regulates TGIF (show IL10 Proteins)-induced Nox4 (show NOX4 Proteins) activation and subsequent superoxide production.

  6. TGIF1 has a role as a negative regulator of MLL (show MLL Proteins)-rearranged acute myeloid leukemia (show BCL11A Proteins)

  7. TG-interacting factor transcriptionally induced by AKT (show AKT1 Proteins)/FOXO3A (show FOXO3 Proteins) is a negative regulator that antagonizes arsenic trioxide-induced cancer cell apoptosis.

  8. TG-interacting factor 1 (Tgif1) is an important repressor of SOAT2 (show SOAT2 Proteins) gene expression.

  9. TGIF1 is a relevant candidate gene with potential to contribute in the genesis of high myopia.

  10. Alternative splicing of TGIF1 is deregulated in OSCC, with overexpression of some splicing variants, especially TGIF1v8, which is associated with advanced stages of OSCC.

Mouse (Murine) TGFB-Induced Factor Homeobox 1 (TGIF1) interaction partners

  1. Tgif1 counterbalances the activity of core pluripotency factors, Oct4, Sox2, and Nanog, in mouse embryonic stem cells.

  2. Tgif1 suppresses stem cell self-renewal.

  3. The identification and characterization of the Tgif mutant supports the role of TGFbeta (show TGFB1 Proteins) signalling in the development of chronic OM.

  4. Tgif1 mutation in mouse contributes to Holoprosencephaly pathogenesis due to disruption of the Shh (show SHH Proteins) pathway

  5. TGIF1 plays a role in TNF-alpha (show TNF Proteins)- and radiation-induced inflammation and it could be a target in limiting this event in the vascular compartment

  6. TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) co-repressor TGIF1 plays a role in radiation-induced normal tissue damage by a Smad (show SMAD1 Proteins)-independent mechanism.

  7. Data suggest that in the absence of Tgif1, a persistent increase in TGFbeta (show TGFB1 Proteins) responsive transcription and a reduced ability to deal with hyperoxic stress result in premature senescence in primary MEFs.

  8. mRNA for positive regulators of Fshb (show FSHB Proteins) expression, such as Fos and Jun (show JUN Proteins), were up-regulated at slower pulse frequencies than a number of potential negative regulators, such as the corepressors Skil (show SKIL Proteins), Crem (show CREM Proteins), and Tgif1.

  9. Tgif1 can regulate nuclear receptor complexes, in addition to those containing retinoic acid receptors, but also indicates that there is some specificity to which NR target genes are repressed by Tgif1.

  10. Data show that loss-of-function mutations in both Tgif1 and Tgif2 (show TGIF2 Proteins) result in a failure of gastrulation.

TGIF1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.

Alternative names and synonyms associated with TGIF1

  • TGFB-induced factor homeobox 1 (tgif1)
  • TGFB-induced factor homeobox 1 (TGIF1)
  • TGFB-induced factor homeobox 1 (Tgif1)
  • AA959811 protein
  • AI462167 protein
  • fa06h05 protein
  • fb33g11 protein
  • HPE4 protein
  • Tfig protein
  • TGIF protein
  • tgif1 protein
  • wu:fa06h05 protein
  • wu:fb33g11 protein
  • zgc:55852 protein

Protein level used designations for TGIF1

TG interacting factor , TGFB-induced factor (TALE family homeobox) , avian knotted-related protein , homeobox protein AKR , homeodomain protein AKR , TGFB-induced factor homeobox 1 , TG-interacting homeobox protein , 5'-TG-3'-interacting factor 1 , TALE homeobox TG-interacting factor , homeobox protein TGIF1 , transforming growth factor-beta-induced factor , TALE family homeobox , TG interacting factor 1 , TG-interacting factor

GENE ID SPECIES
321756 Danio rerio
395014 Xenopus (Silurana) tropicalis
396339 Gallus gallus
694580 Macaca mulatta
100303488 Saccoglossus kowalevskii
7050 Homo sapiens
510050 Bos taurus
21815 Mus musculus
316742 Rattus norvegicus
455312 Pan troglodytes
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