TGIF1 Protein (His tag)

Catalog No. ABIN2733529

Product Details

Target: TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TGIF1 protein is labelled with His tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human TGIF1 (full length, N-term HIS tag, transcript variant 3) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the N-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))

Alternative Name: Tgif1 (TGIF1 Products)

Synonyms: HPE4 Protein, TGIF Protein, AA959811 Protein, AI462167 Protein, Tgif Protein, Tfig Protein, fa06h05 Protein, fb33g11 Protein, zgc:55852 Protein, wu:fa06h05 Protein, wu:fb33g11 Protein, hpe4 Protein, tgif Protein, tgif1 Protein, TGFB induced factor homeobox 1 Protein, TGFB-induced factor homeobox 1 Protein, TGFB induced factor homeobox 1 S homeolog Protein, TGIF1 Protein, Tgif1 Protein, tgif1 Protein, tgif1.S Protein

Background: The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described.

Molecular Weight: 29.6 kDa

NCBI Accession: NP_775300

Pathways: Retinoic Acid Receptor Signaling Pathway, Chromatin Binding, Tube Formation