Browse our CIRBP Proteins (CIRBP)

Full name:
Cold Inducible RNA Binding Protein Proteins (CIRBP)
On are 18 Cold Inducible RNA Binding Protein (CIRBP) Proteins from 8 different suppliers available. Additionally we are shipping CIRBP Antibodies (103) and CIRBP Kits (11) and many more products for this protein. A total of 144 CIRBP products are currently listed.
A18 hnRNP, APBP-1, cirbp, cirbp-a, cirbp-b, cirbp2, Cirp, cirp-1, cirp1, R74941, XCIRP, XCIRP-1, zgc:136559
list all proteins Gene Name GeneID UniProt
CIRBP 1153 Q14011
CIRBP 12696 P60824
CIRBP 81825  

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CIRBP Proteins (CIRBP) by Origin

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Top referenced CIRBP Proteins

  1. Human CIRBP Protein expressed in Escherichia coli (E. coli) - ABIN667435 : Nishiyama, Higashitsuji, Yokoi, Itoh, Danno, Matsuda, Fujita: Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene. in Gene 1998 (PubMed)
    Show all 2 references for 667435

  2. Human CIRBP Protein expressed in HEK-293 Cells - ABIN2714194 : Qiang, Yang, Wu, Zhou, Jacob, Dong, Kuncewitch, Ji, Yang, Wang, Fujita, Nicastro, Coppa, Tracey, Wang: Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis. in Nature medicine 2013 (PubMed)

  3. Human CIRBP Protein expressed in Wheat germ - ABIN1349496 : Mangé, Lacombe, Bascoul-Mollevi, Jarlier, Lamy, Rouanet, Maudelonde, Solassol: Serum autoantibody signature of ductal carcinoma in situ progression to invasive breast cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012 (PubMed)

More Proteins for CIRBP Interaction Partners

Xenopus laevis Cold Inducible RNA Binding Protein (CIRBP) interaction partners

  1. XCIRP is required to maintain the expression of adhesion molecules and cell movement during embryonic development.

  2. Cold-inducible RNA binding protein XCIRP regulates anterior neural development in Xenopus.

Human Cold Inducible RNA Binding Protein (CIRBP) interaction partners

  1. In human abdominal aortic aneurysm (AAA (show APP Proteins)) tissue, Cold-inducible RNA-binding protein (CIRP) exhibited a 5.6-fold and 93% increase in mRNA and protein expression, respectively. In a rat AAA (show APP Proteins) model, CIRP was upregulated significantly in a time-dependent manner in the serum and AAA (show APP Proteins) tissue.

  2. We found out that the link between CIRP and Snail (show SNAI1 Proteins) is mediated by ERK (show EPHB2 Proteins) and p38 (show CRK Proteins) pathways. EMT (show ITK Proteins) is a critical component of carcinoma metastasis and invasion. As demonstrated in this study, the biological role of CIRP in EMT (show ITK Proteins) may explain why CIRP overexpression has been associated with a bad prognosis in cancer patients.

  3. CIRP was expressed in the bronchi of human COPD (show ARCN1 Proteins) patients and was involved in inflammatory factors and MUC5AC expression after cold stimulation through the ERK (show EPHB2 Proteins) and NF-kappaB (show NFKB1 Proteins) pathways

  4. Low CIRP expression is associated with colon Cancer.

  5. this study shows that CIRP expression in bronchial airway epithelial cells of patients with chronic obstructive pulmonary disease is higher than that in healthy person

  6. We generated a transgenic mouse model overexpressing human CIRP in the mammary epithelium to ask if it plays a role in mammary gland development. Effects of CIRP overexpression on mammary gland morphology, cell proliferation, and apoptosis were studied from puberty through pregnancy, lactation and weaning

  7. Increased synovial fluid CIRP concentrations were closely associated with the severity of knee osteoarthritis

  8. hnRNP (show HNRNPC Proteins) A18 can promote tumor growth in in vivo models by coordinating the translation of pro-survival transcripts to support the demands of proliferating cells and increase survival under cellular stress.

  9. Clinically, CIRP overexpression is significantly correlated with Cushing's disease recurrence. CIRP appears to play a critical tumorigenesis function in Cushing's disease and its expression might be a useful biomarker for tumor recurrence.

  10. CIRP protein regulates telomerase activity in a temperature-dependent manner by regulating the level of TERT (show TERT Proteins) mRNAs.

Mouse (Murine) Cold Inducible RNA Binding Protein (CIRBP) interaction partners

  1. temperature-dependent accumulation of Cirbp mRNA is controlled primarily by the regulation of splicing efficiency, defined as the fraction of Cirbp pre-mRNA processed into mature mRNA

  2. this paper shows that cold air stimulation induced MUC5AC expression in wild-type mice but not in CIRP-/-) mice.

  3. state. These data collectively suggest that a deficiency in CIRP accelerates the wound healing process

  4. These results can provide new insights into the molecular mechanisms of Cirp function.

  5. Findings suggest that CIRP could exert protective effects against oxidative stress, and that it might be a novel neuroprotective agent

  6. targeting CIRP offers potential therapeutic implications in the treatment of hepatic I/R injury.

  7. Cirp appears to play a critical carcinogenic function and its expression might be a useful biomarker for hepatocellular carcinomas risk prediction.

  8. Cirp promotes the development of intestinal inflammation and colorectal tumors through regulating apoptosis and production of TNFalpha (show TNF Proteins) and IL23 (show IL23A Proteins) in inflammatory cells.

  9. alcohol exposure activates microglia to produce and secrete CIRP

  10. Extracellular CIRP is a detrimental factor in stimulating inflammation to cause neuronal damage in cerebral ischemia

CIRBP Protein Profile

Protein Summary

Cold-inducible mRNA binding protein. Acts cooperatively with elavl1/elrA to stabilize AU-rich element (ARE)-containing mRNAs by binding to themm and inhibiting their deadenylation. Essential for embryonic gastrulation and neural development, acting to maintain the expression of a set of adhesion molecules, and cell movement during embryogenesis. Required for pronephros development (By similarity).

Alternative names and synonyms associated with CIRBP

  • cold inducible RNA binding protein (cirbp)
  • cold-inducible RNA-binding protein (EDI_107320)
  • cold inducible RNA binding protein (CIRBP)
  • hyperosmotic glycine rich protein-like (LOC100194590)
  • cold inducible RNA binding protein (cirbp-a)
  • cold inducible RNA binding protein (Cirbp)
  • A18 hnRNP protein
  • APBP-1 protein
  • cirbp protein
  • cirbp-a protein
  • cirbp-b protein
  • cirbp2 protein
  • Cirp protein
  • cirp-1 protein
  • cirp1 protein
  • R74941 protein
  • XCIRP protein
  • XCIRP-1 protein
  • zgc:136559 protein

Protein level used designations for CIRBP

cold-inducible RNA-binding protein , Glycine-rich RNA-binding protein CIRP , glycine-rich RNA-binding protein CIRP , hyperosmotic glycine rich protein-like , Cold-inducible RNA-binding protein , cold inducible RNA binding protein , Cold-inducible RNA-binding protein-1 , Glycine-rich RNA-binding protein CIRP-A , cold inducible RNA-binding protein , cold-inducible RNA-binding protein 1 , cold-inducible RNA-binding protein A , aggrecan promoter binding protein , A18 hnRNP , glycine-rich RNA binding protein , cold-inducible RNA binding protein

549982 Xenopus (Silurana) tropicalis
5881604 Entamoeba dispar SAW760
100171539 Pongo abelii
100194590 Salmo salar
100305215 Oncorhynchus mykiss
678563 Danio rerio
379761 Xenopus laevis
425789 Gallus gallus
1153 Homo sapiens
476755 Canis lupus familiaris
507120 Bos taurus
12696 Mus musculus
81825 Rattus norvegicus
100522851 Sus scrofa
100689075 Cricetulus griseus
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