Browse our CLP1 Proteins (CLP1)

Full name:
Cleavage and Polyadenylation Factor I Subunit 1 Proteins (CLP1)
On are 9 Cleavage and Polyadenylation Factor I Subunit 1 (CLP1) Proteins from 4 different suppliers available. Additionally we are shipping CLP1 Antibodies (49) and many more products for this protein. A total of 64 CLP1 products are currently listed.
AI462438, hClp1, Heab, MLL2, RGD1307679
list all proteins Gene Name GeneID UniProt
CLP1 10978 Q92989
CLP1 311166 Q5PQL4
CLP1 98985 Q99LI9

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CLP1 Proteins (CLP1) by Origin

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More Proteins for CLP1 Interaction Partners

Human Cleavage and Polyadenylation Factor I Subunit 1 (CLP1) interaction partners

  1. Study reports the identification of a human CLP1 (show HEXIM1 Proteins) mutation that impairs tRNA splicing in vitro and causes a neurological syndrome involving both the central nervous system (CNS) and peripheral nervous system (PNS).

  2. Data link tRNA maturation to neuronal development and neurodegeneration through defective CLP1 (show HEXIM1 Proteins) function in humans.

  3. the kinase hClp1 phosphorylates and licenses synthetic siRNAs to become assembled into RISC for subsequent target RNA cleavage

  4. Expression of hClp1 in budding yeast can complement conditional and lethal mutations in the essential 5'-OH RNA kinase module of yeast or plant tRNA ligases.

  5. HEAB is a pre-mRNA 3'-end processing factor, which bridges two other pre-mRNA processing (show PRPF39 Proteins) factors (CF Im and CPSF (show CPSF3 Proteins)) and is involved in cleavage of the pre-mRNA. It can be UV-crosslinked to GTP (show AK3 Proteins).

Mouse (Murine) Cleavage and Polyadenylation Factor I Subunit 1 (CLP1) interaction partners

  1. loss of CLP1 (show CNNM1 Proteins) activity results in accumulation of a novel set of small RNA fragments derived from aberrant processing of tyrosine pre-transfer RNA; these tRNA fragments sensitize cells to oxidative-stress-induced (show SQSTM1 Proteins) p53 (show TP53 Proteins) activation and p53 (show TP53 Proteins)-dependent cell death

  2. associates with MyoD (show MYOD1 Proteins) and HDAC (show HDAC3 Proteins) to restore skeletal muscle cell regeneration

  3. regulation of the CLP-1 (show CNNM1 Proteins) levels is critical to cellular adaptation of the survival program that protects cardiomyocytes against stress

CLP1 Protein Profile

Protein Summary

Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing\; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA- induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity).

Alternative names and synonyms associated with CLP1

  • cleavage and polyadenylation factor I subunit 1 (CLP1)
  • cleavage and polyadenylation factor I subunit 1 (Clp1)
  • CLP1, cleavage and polyadenylation factor I subunit (Clp1)
  • CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae) (CLP1)
  • lysine (K)-specific methyltransferase 2D (KMT2D)
  • AI462438 protein
  • hClp1 protein
  • Heab protein
  • MLL2 protein
  • RGD1307679 protein

Protein level used designations for CLP1

ATP/GTP-binding protein , CLP1, cleavage and polyadenylation factor I subunit, homolog , homolog of yeast CFIA subunit Clp1p , polyadenylation factor Clp1 , polynucleotide kinase Clp1 , polyribonucleotide 5'-hydroxyl-kinase Clp1 , pre-mRNA cleavage complex II protein Clp1 , myeloid/lymphoid or mixed-lineage leukemia 2

10978 Homo sapiens
311166 Rattus norvegicus
98985 Mus musculus
506507 Bos taurus
423131 Gallus gallus
506805 Bos taurus
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