Browse our MBNL1 (MBNL1) ELISA Kits

Full name:
Muscleblind-Like (Drosophila) ELISA Kits (MBNL1)
On www.antibodies-online.com are 3 Muscleblind-Like (Drosophila) (MBNL1) ELISA Kits from 1 different suppliers available. Additionally we are shipping MBNL1 Antibodies (116) and MBNL1 Proteins (13) and many more products for this protein. A total of 136 MBNL1 products are currently listed.
Synonyms:
EXP, EXP35, EXP40, EXP42, MBNL, MBNL1, mKIAA0428, zgc:153954
list all ELISA KIts Gene Name GeneID UniProt
MBNL1 56758 Q9JKP5
MBNL1 4154 Q9NR56
Rat MBNL1 MBNL1 282635  

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Mouse (Murine) Muscleblind-Like (Drosophila) (MBNL1) interaction partners

  1. our study uncovered a novel, autoregulatory function of MBNL proteins based on their binding to e1 of MBNL1 transcript. This function might facilitate cellular protection from MBNL protein level fluctuations, which might otherwise lead to adverse effects caused by extreme MBNL content.

  2. Data show that Muscleblind-like 1 (Mbnl1) and Muscleblind-Like 3 (Mbnl3) bind skeletal muscle chloride channel CIC-1 (Clc-1) mRNA.

  3. Depletion of Mbnl1 and/or Mbnl2 (show MBNL2 ELISA Kits) reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites

  4. Sense DMPK (show DMPK ELISA Kits) RNA foci clearly co-localize with MBNL1 and MBNL2 (show MBNL2 ELISA Kits) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  5. MBNL1 overexpression promotes transformation of fibroblasts into myofibroblasts.

  6. These data indicate that MBNL1 plays a conserved role in negatively regulating TGFbeta (show TGFB1 ELISA Kits) signaling, and is required for normal valve morphogenesis and homeostasis in vivo.

  7. this study supports a key role for Mbnl1 loss in the initiation of DM1 cardiac disease.

  8. Differential expression of Mbnl1 in development plays a role in alternative splicing of vesicular trafficking genes in postnatal heart development.

  9. Results show that nuclear localization is a major determinant of MBNL1 function. It promotes the nuclear retention of repeat-containing transcripts, which results in repression of aberrant protein expression from the expanded repeats.

  10. depletion of Mbnl proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events.

Human Muscleblind-Like (Drosophila) (MBNL1) interaction partners

  1. RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2

  2. Our work suggests that DM1 (show DMPK ELISA Kits) patients are at risk for Fuchs' endothelial corneal dystrophy (FECD (show COL8a2 ELISA Kits)). DMPK (show DMPK ELISA Kits) mutations contribute to the genetic burden of FECD (show COL8a2 ELISA Kits) but are uncommon. We establish a connection between two repeat expansion disorders converging upon RNA-MBNL1 foci and FECD (show COL8a2 ELISA Kits).

  3. Binding of the MBNL zinc fingers to cardiac troponin T (show TNNT2 ELISA Kits) pre-mRNA is specific and relatively simple, unlike the complex multiple dimer-trimer stoichiometries postulated in some previous studies.

  4. Heterozygous missense mutations and one in-frame deletion in MBNL1 were identified in 3 myotonic dystrophy patients.

  5. Nuclear retention of full-length HTT (show HTT ELISA Kits) RNA is mediated by splicing factors MBNL1 and U2AF65 (show U2AF59 ELISA Kits)

  6. muscleblind-like 1 (MBNL1) is a robust suppressor of multiorgan breast cancer metastasis. It binds the 3' untranslated regions of DBNL (show DBNL ELISA Kits) and TACC1 (show TACC1 ELISA Kits) -two genes that are implicated as metastasis suppressors.

  7. Sense DMPK (show DMPK ELISA Kits) RNA foci clearly co-localize with MBNL1 and MBNL2 (show MBNL2 ELISA Kits) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  8. abnormal splicing of DMD (show DMD ELISA Kits) exon 78 found in dystrophic muscles of DM1 (show DMPK ELISA Kits) patients is due to the functional loss of MBNL1 and leads to the re-expression of an embryonic dystrophin (show DMD ELISA Kits) in place of the adult isoform.

  9. Reduced RBFOX1 (show A2BP1 ELISA Kits) activity in myotonic dystrophy type 1 tissues may amplify several of the splicing alterations caused by the deficiency in MBNL1.

  10. MBNL1 binds with C allelic pre-miR (show MLXIP ELISA Kits)-1307 leading to low expression of miR (show MLXIP ELISA Kits)-1307-3p in colorectal cancer.

MBNL1 Antigen Profile

Antigen Summary

Involved in pre-mRNA alternative splicing regulation. Binds to CUG triplet repeat in RNA (By similarity).

Alternative names and synonyms associated with MBNL1

  • muscleblind-like (Drosophila) (MBNL1) Elisa Kit
  • muscleblind-like (Drosophila) (mbnl1) Elisa Kit
  • muscleblind-like 1 (Drosophila) (Mbnl1) Elisa Kit
  • muscleblind-like splicing regulator 1 (MBNL1) Elisa Kit
  • muscleblind-like splicing regulator 1 (Mbnl1) Elisa Kit
  • EXP Elisa Kit
  • EXP35 Elisa Kit
  • EXP40 Elisa Kit
  • EXP42 Elisa Kit
  • MBNL Elisa Kit
  • MBNL1 Elisa Kit
  • mKIAA0428 Elisa Kit
  • zgc:153954 Elisa Kit

Protein level used designations for MBNL1

muscleblind-like , muscleblind-like (Drosophila) , muscleblind-like protein 1 , muscleblind-like 1 , triplet-expansion RNA-binding protein

GENE ID SPECIES
100218825 Taeniopygia guttata
100559321 Anolis carolinensis
100583541 Nomascus leucogenys
767696 Danio rerio
425033 Gallus gallus
56758 Mus musculus
4154 Homo sapiens
477116 Canis lupus familiaris
781653 Bos taurus
282635 Rattus norvegicus
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