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Human NPM1 Protein expressed in Wheat germ - ABIN1312882
Xu, Fang, Dhar, St Clair, Kasarskis, St Clair: The role of a single-stranded nucleotide loop in transcriptional regulation of the human sod2 gene. in The Journal of biological chemistry 2007
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Our results indicate that CD4 (show CD4 Proteins) expression and older age are adverse prognostic factors in wild-type NPM1, FLT3 (show FLT3 Proteins)-ITD-negative CN-AML (show RUNX1 Proteins).
NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (show CASP2 Proteins) activation cascade.
Data indicate that NPM-ALK was distributed in equal amounts between the cytoplasm and the nucleus.
The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers. [review]
revealed that the localization of fluorescently labeled NPM is affected by the interaction between various forms of the protein
value of mutated NPM1 in AML (show RUNX1 Proteins) in risk assessment and evaluating prognosis
NPM1 downregulation by P-STAT5 (show STAT5A Proteins) is mediated by impairing the BRCA1-BARD1 (show BARD1 Proteins) ubiquitin ligase, which controls the stability of NPM1. In turn, decreased NPM1 levels led to suppression of p53 (show TP53 Proteins) expression, resulting in enhanced cell survival.
These results suggest that the p38 (show CRK Proteins)/NPM/PP2A (show PPP2R4 Proteins) complex acts as a dynamic sensor, allowing endothelial cells to react rapidly to acute oxidative stress.
Nucleophosmin-anaplastic lymphoma kinase serves as the founding member of the ALK fusion protein family, and its role in malignant cell transformation is by far the best characterized and, thus, is the main focus of this review. [review]
Data suggest that C11orf98 microprotein, NPM1, and nucleolin (show NCL Proteins) interact and colocalize in the cell nucleolus. (C11orf98 = chromosome 11 open reading frame 98 protein; NPM1 = nucleophosmin 1)
Results suggest that some polymorphisms in NPM1 are associated with body weight at some ages and may be used as candidates for marker-assisted selection and management in beef cattle breeding programmes.
The NPM1 gene is a candidate gene for growth traits in cattle.
NPM1 (show GJA1 Proteins)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (show CASP2 Proteins) activation cascade.
NPM1 (show GJA1 Proteins) knockdown decreased NF-kappaB (show NFKB1 Proteins)-mediated transcription of selected target genes by decreasing the recruitment of NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) to the gene promoters.
study suggests that although neurons need NPM1 (show GJA1 Proteins) for survival, an increase in its expression beyond physiological levels and its translocation to the cytoplasm leads to death through abortive cell cycle induction.
The levels of B23 expression are directly regulated by EGR1 (show EGR1 Proteins).
IDH2 (show IDH2 Proteins) and NPM1 (show GJA1 Proteins) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Proteins) stem-like cells.
Lrrc34, a novel nucleolar protein (show MCRS1 Proteins), interacts with npm1 (show GJA1 Proteins) and ncl (show NCL Proteins) and has an impact on pluripotent stem cells
a function of NPM1 (show GJA1 Proteins) in the spatial organization of nucleolus-associated heterochromatin through DNA methyltransferase (show DNMT1 Proteins) DNMT3A (show DNMT3A Proteins)
The data presented here support a novel role for NPM1 (show GJA1 Proteins) as a multilevel modulator of the base excision repair pathway.
The mechanism of G-CSF's neuroprotection may be related in part to attenuating neuronal apoptosis by NPM1 (show GJA1 Proteins).
In conclusion, we successfully established xenotransplantation model of human FLT3 (show FLT3 Proteins)-ITD (mut (show MUT Proteins)) /NPM1 (show GJA1 Proteins) (-) CN-AML (show RUNX1 Proteins) in NOD/SCID (show PRKDC Proteins) mice.
NLP is essential for the positioning of centromeres during cell division in Drosophila.
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
, nucleophosmin/nucleoplasmin, 4
, nucleolar protein NO38
, nucleophosmin/nucleoplasmin family, member 1
, nucleolar phosphoprotein B23
, nucleolar protein B23.1
, nucleophosmin 1
, chromatin decondensation protein 1