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the involvement of TDRD1 genetic polymorphisms in piRNA processing genes in the risk of spermatogenic impairment in a Han Chinese population
ERG (show ERG Proteins) induces epigenetic activation of Tudor domain-containing protein 1 (TDRD1) in ERG (show ERG Proteins) rearrangement-positive prostate cancer.
TDRD1 is the first identified upregulated direct ERG (show ERG Proteins) target gene that is strongly associated with ERG (show ERG Proteins) overexpression in primary prostate cancer
TDRD1 can accommodate different peptides from different proteins, and can therefore act as a scaffold protein (show HOMER1 Proteins) for complex assembly in the piRNA pathway.
Data suggest that the formation of complexes between MILI, MIWI (show PIWIL1 Proteins) and TDRD1/MTR-1 is critical for the integrated subcellular localizations of these proteins, and is presumably essential for spermatogenesis.
isolated Mouse tudor repeat-1 (Mtr-1) which encodes a MYND domain and four copies of the tudor domain. Mtr-1 is expressed in germ-line cells and is most abundant in fetal prospermatogonia and postnatal primary spermatocytes.
targeted mutation in Tudor domain containing 1/mouse tudor repeat 1 (Tdrd1/Mtr-1), a tudor-related gene in mice, leads to male sterility because of postnatal spermatogenic defects
Results suggest that Mili interacts with Tdrd1 in the nuage and chromatoid body, and that this interaction does not contribute to piRNA biogenesis but represents a regulatory mechanism that is critical for spermatogenesis.
Tdrd1 ensures the entry of correct transcripts into the normal piRNA pool.
Tdrd1 is required for efficient Piwi-pathway activity and proper nuage formation. It binds Ziwi & Zili, with sequence specificity in the interaction between Tdrd1 tudor domains & symmetrically dimethylated arginines in Zili.
This gene is similar to a mouse gene that encodes a tudor domain protein. Alternatively spliced transcript variants have been described but their full length sequences have not been determined.
tudor domain containing 1
, tudor domain containing protein 1
, cancer/testis antigen 41.1
, tudor domain-containing protein 1