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secretion of IL-13 (show IL13 Proteins) and amphiregulin suggests Intrahepatic Innate lymphoid cells may be recruited to promote resolution and repair and thereby they may contribute to ongoing fibrogenesis in liver disease.
EGF (show EGF Proteins)-AREG interplay in airway basal cell stem/progenitor cells is one of the mechanisms that mediates the interconnected pathogenesis of all major smoking-induced lesions in the human airway epithelium.
AREG expression may be useful for identifying CRTC1-MAML2-positive mucoepidermoid carcinomas and as a marker for favorable prognosis.
Amphiregulin enhances VEGF-A (show VEGFA Proteins) production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR (show MLXIP Proteins)-206 via FAK (show PTK2 Proteins)/c-Src (show SRC Proteins)/PKCdelta (show PKCd Proteins) pathway.
Amphiregulin plays an important role in lung neoplasm resistance to amrubicinol
EREG (show EREG Proteins) and AREG are strongly regulated by methylation, and their expression is associated with CIMP status and primary tumour site.
These findings demonstrate the posttranslational regulation of Foxp3 (show FOXP3 Proteins) expression by AREG in cancer patients through AREG/EGFR (show EGFR Proteins)/GSK-3beta signaling, which could lead to Foxp3 (show FOXP3 Proteins) protein degradation in Treg cells and a potential therapeutic target for cancer treatment.
blocking soluble amphiregulin with a neutralizing antibody also significantly increased apoptotic cell death of HepG2 cells due to treatment with methyl methanesulfonate, cisplatin, or a recombinant p53 (show TP53 Proteins) adenovirus, suggesting that the function of amphiregulin involved in inhibiting apoptosis may be a common mechanism by which hepatoma cells escape from stimulus-induced apoptosis
Low AREG expression is associated with gastric cancer.
RYR2, PTDSS1 (show PTDSS1 Proteins) and AREG are autism susceptibility genes that are implicated in a Lebanese population-based study of copy number variations in this disease.
activated alveolar macrophages also exerted a protective effect on the lung tissues by producing high-level amphiregulin in lipopolysaccharide-induced acute lung injury
AREG overexpression in osteoblasts induces a transient high bone mass phenotype in the trabecular compartment of the appendicular skeleton by a growth-related, non-cell autonomous mechanism
AREG-silenced keratinocytes plays an important role in regulation cell proliferation.
Hepatic CD206 (show MRC1 Proteins)-positive macrophages express amphiregulin to promote the immunosuppressive activity of regulatory T cells in HBV infection.
Areg may have a role in classically activated macrophages
After activation with IL-33 (show IL33 Proteins), expression of AREG is a dominant functional signature of gut (show GUSB Proteins)-associated IL-33 (show IL33 Proteins)-dependent group 2 innate lymphoid cells. The frequency and number of AREG-expressing ILC2s increases following intestinal injury.
AR induces hHSC fibrogenic activity via multiple mitogenic signaling pathways, and is upregulated in murine and human NASH, suggesting that AR antagonists may be clinically useful anti-fibrotics in NAFLD.
hormones and/or factors in addition to E that upregulate AREG can promote mammary gland development and have the potential to affect breast cancer risk associated with pubertal mammary gland development
Our data show that AREG is essential for ultraviolet therapy-induced contact hypersensitivity suppression.
Pre-maturation with cAMP modulators in conjunction with EGF (show EGF Proteins)-like peptides during in vitro maturation enhances mouse oocyte developmental competence.
LH and AREG decrease BNP and CNP (show NPPC Proteins) production in granulosa cells and down-regulate NPR2 (show NPRL2 Proteins) expression in cumulus cells, which together decreased oocyte cGMP to levels that permit meiotic resumption.
cloning the complete coding region; comparison of endometrial amphiregulin mRNA expression in Meishan and White composite pigs
Amphiregulin co-operates with bone morphogenetic protein 15 (show BMP15 Proteins) to increase bovine oocyte developmental competence.
Data suggest that epidermal growth factor receptor (show EGFR Proteins) B [ErbB (show EGFR Proteins)] isoforms and their ligands (epidermal growth factor (show EGF Proteins) [EGF (show EGF Proteins)], amphiregulin [AREG], and neuregulin-1 (show NRG1 Proteins) [NRG1 (show NRG1 Proteins)]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.
colorectum cell-derived growth factor
, schwannoma-derived growth factor
, amphiregulin (schwannoma-derived growth factor)
, amphiregulin long form
, amphiregulin B
, Schwannoma-derived growth factor