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Mouse (Murine) Amphiregulin Protein expressed in Escherichia coli (E. coli) - ABIN2666769
Plowman, Green, McDonald, Neubauer, Disteche, Todaro, Shoyab: The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. in Molecular and cellular biology 1990
Show all 9 references for ABIN2666769
activated alveolar macrophages also exerted a protective effect on the lung tissues by producing high-level amphiregulin in lipopolysaccharide-induced acute lung injury
AREG overexpression in osteoblasts induces a transient high bone mass phenotype in the trabecular compartment of the appendicular skeleton by a growth-related, non-cell autonomous mechanism
AREG-silenced keratinocytes plays an important role in regulation cell proliferation.
Hepatic CD206 (show MRC1 Proteins)-positive macrophages express amphiregulin to promote the immunosuppressive activity of regulatory T cells in HBV infection.
Areg may have a role in classically activated macrophages
After activation with IL-33 (show IL33 Proteins), expression of AREG is a dominant functional signature of gut (show GUSB Proteins)-associated IL-33 (show IL33 Proteins)-dependent group 2 innate lymphoid cells. The frequency and number of AREG-expressing ILC2s increases following intestinal injury.
AR induces hHSC fibrogenic activity via multiple mitogenic signaling pathways, and is upregulated in murine and human NASH, suggesting that AR antagonists may be clinically useful anti-fibrotics in NAFLD.
hormones and/or factors in addition to E that upregulate AREG can promote mammary gland development and have the potential to affect breast cancer risk associated with pubertal mammary gland development
Our data show that AREG is essential for ultraviolet therapy-induced contact hypersensitivity suppression.
Pre-maturation with cAMP modulators in conjunction with EGF (show EGF Proteins)-like peptides during in vitro maturation enhances mouse oocyte developmental competence.
LH and AREG decrease BNP and CNP (show NPPC Proteins) production in granulosa cells and down-regulate NPR2 (show NPRL2 Proteins) expression in cumulus cells, which together decreased oocyte cGMP to levels that permit meiotic resumption.
cloning the complete coding region; comparison of endometrial amphiregulin mRNA expression in Meishan and White composite pigs
These findings demonstrate the posttranslational regulation of Foxp3 (show FOXP3 Proteins) expression by AREG in cancer patients through AREG/EGFR (show EGFR Proteins)/GSK-3beta signaling, which could lead to Foxp3 (show FOXP3 Proteins) protein degradation in Treg cells and a potential therapeutic target for cancer treatment.
blocking soluble amphiregulin with a neutralizing antibody also significantly increased apoptotic cell death of HepG2 cells due to treatment with methyl methanesulfonate, cisplatin, or a recombinant p53 (show TP53 Proteins) adenovirus, suggesting that the function of amphiregulin involved in inhibiting apoptosis may be a common mechanism by which hepatoma cells escape from stimulus-induced apoptosis
Low AREG expression is associated with gastric cancer.
RYR2, PTDSS1 (show PTDSS1 Proteins) and AREG are autism susceptibility genes that are implicated in a Lebanese population-based study of copy number variations in this disease.
High Amphiregulin enhances intercellular adhesion molecule-1 (show ICAM1 Proteins) expression and promotes tumor metastasis in osteosarcoma.
results demonstrate that AREG controls G2/M progression and cytokinesis in keratinocytes via activation of a FoxM1 (show FOXM1 Proteins)-dependent transcriptional program, suggesting new avenues for treatment of epithelial cancer
High expression of amphiregulin is associated with hepatocellular carcinoma.
Findings show the involvement of amphiregulin and semaphorin-3A (show SEMA3A Proteins) in the improvement of skin innervations and penetration of nerve fibers into the epidermis.
Altered AREG expression induced by diverse luteinizing hormone receptor (show LHCGR Proteins) reactivity in granulosa cells may provide a useful marker for oocyte developmental competency
Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf (show RAF1 Proteins)/MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins)/AP-1 (show FOSB Proteins) pathway.
Amphiregulin co-operates with bone morphogenetic protein 15 (show BMP15 Proteins) to increase bovine oocyte developmental competence.
Data suggest that epidermal growth factor receptor (show EGFR Proteins) B [ErbB (show EGFR Proteins)] isoforms and their ligands (epidermal growth factor (show EGF Proteins) [EGF (show EGF Proteins)], amphiregulin [AREG], and neuregulin-1 (show NRG1 Proteins) [NRG1 (show NRG1 Proteins)]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
schwannoma-derived growth factor
, amphiregulin (schwannoma-derived growth factor)
, amphiregulin long form
, colorectum cell-derived growth factor
, Schwannoma-derived growth factor
, amphiregulin B