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anti-Human Angiopoietin 1 Antibodies:
anti-Mouse (Murine) Angiopoietin 1 Antibodies:
anti-Rat (Rattus) Angiopoietin 1 Antibodies:
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Human Polyclonal Angiopoietin 1 Primary Antibody for IF (p), IHC (p) - ABIN728323
Lv, Fan, Su: Is a swine model of arteriovenous malformation suitable for human extracranial arteriovenous malformation? A preliminary study. in Cardiovascular and interventional radiology 2013
Show all 4 Pubmed References
Mouse (Murine) Polyclonal Angiopoietin 1 Primary Antibody for IHC, WB - ABIN95109
Dallabrida, Ismail, Pravda, Parodi, Dickie, Durand, Lai, Cassiola, Rogers, Rupnick: Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy. in The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
Show all 2 Pubmed References
Human Polyclonal Angiopoietin 1 Primary Antibody for IHC (p), WB - ABIN965551
Suri, Jones, Patan, Bartunkova, Maisonpierre, Davis, Sato, Yancopoulos: Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. in Cell 1997
Show all 3 Pubmed References
Human Polyclonal Angiopoietin 1 Primary Antibody for IHC, IHC (p) - ABIN4280606
Zibert, Wallbrecht, Schön, Mir, Jacobsen, Trochon-Joseph, Bouquet, Villadsen, Cadossi, Skov, Schön: Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine psoriasiform skin lesions. in The Journal of clinical investigation 2011
Chicken Monoclonal Angiopoietin 1 Primary Antibody for IHC (fro), IHC (p) - ABIN259879
Regula, Lundh von Leithner, Foxton, Barathi, Cheung, Bo Tun, Wey, Iwata, Dostalek, Moelleken, Stubenrauch, Nogoceke, Widmer, Strassburger, Koss, Klein, Shima, Hartmann: Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases. in EMBO molecular medicine 2016
These results indicate that the Angpt-Tie2 (show TEK Antibodies) system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 (show TEK Antibodies) agonists could be a therapeutic option for glaucoma.
Ang-1 specifically increases circulating Gr1(+ )inflammatory monocytes and increases monocyte/macrophage retention in atherosclerotic plaques, thereby contributing to development of atherosclerosis.
NOX2 (show CYBB Antibodies), NOX4 (show NOX4 Antibodies), and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 signaling and angiogenic responses in endothelial cells.
ANG-1, ANG-2 (show ANGPT2 Antibodies) and TIE-2 (show TEK Antibodies) levels were significantly increased in placenta of non-complicated ART pregnancies compared to placentas from spontaneous conception.
study is the first one to report Ang1 capacity to induce MIP-1beta (show CCL4 Antibodies) gene expression, protein synthesis and release from neutrophils, and that these effects are mediated by PI3K (show PIK3CA Antibodies), p38 MAPK (show MAPK14 Antibodies) and MEK (show MAP2K1 Antibodies) activation and downstream NF-kappaB (show NFKB1 Antibodies) activation
In this study, we found that angiopoietins and Tie receptors were highly expressed in cervical cancer cells. Tie-2 (show TEK Antibodies) expression in tumor cells predicted poorer prognosis.Our data support that dual inhibition of Ang-1 and Ang-2 (show ANGPT2 Antibodies) may be an alternative target for anti-angiogenic adjuvant therapy in advanced or recurrent cervical squamous cell cancer.
Data show that fibulin-5 (show FBLN5 Antibodies) strongly binds to the endothelial cell surface reducing endothelial cell viability and interfering with the signaling pathways of the Ang-1/TIE-2 (show TEK Antibodies) receptor axis.
Ang-1 is not a predictive and clinically relevant biomarker in pulmonary hypertension
We could therefore conclude that angiogenesis is an important event in the development of common skin warts, and the upregulation of both Ang1 and -2 and their binding receptor Tie2 (show TEK Antibodies) may play a role in the angiogenesis associated with the development of these lesions.
In vitro binding assays with purified components reveal that Tie-integrin recognition is direct, and further demonstrate that the receptor binding domain of the Tie2 ligand (show ANGPT2 Antibodies) Ang-1, but not the receptor binding domain of Ang-2 (show ANGPT2 Antibodies), can independently associate with a5b1 or aVb3. cooperative Tie/integrin interactions selectively stimulate ERK/MAPK (show MAPK1 Antibodies) signaling in the presence of both Ang-1 and fibronectin (show FN1 Antibodies)
we demonstrate that targeted Ang-1 overexpression attenuates myofibroblast activation and interstitial collagen I accumulation, inhibits the upregulation of transforming growth factor beta1 and subsequent phosphorylation of Smad 2 (show SMAD2 Antibodies)/3, dampens renal inflammation, and stimulates the growth of peritubular capillaries in the obstructed kidney.
Hydroxysafflor yellow A promotes angiogenesis in ischemic hindlimb via the angiopoietin 1/ Tie-2 (show TEK Antibodies) signaling pathway.
COMP (show COMP Antibodies)-Ang1 can enhance BMP2 (show BMP2 Antibodies)-induced cranial bone regeneration with increased pericyte recruitment. Combined delivery of the proteins might be a therapeutic strategy to repair cranial bone damage.
Hematopoietic stem cells regulate the regeneration of their niche by secreting Angpt1.
Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.
Ang-1 strongly enhances skeletal muscle regeneration in response to fiber injury and that this effect is mediated through induction of the myogenesis program in muscle progenitor cells and the angiogenesis program in endothelial cells.
These results suggest that PRP extract prevents endotoxin-induced pulmonary edema mainly through Ang (show ANG Antibodies)-Tie2 (show TEK Antibodies) signaling, and PRP extract could be a potential therapeutic strategy for sepsis-induced pulmonary edema
E2 increases Ang-1 and enhances capillary density in brain under basal conditions through estrogen receptor-alpha (show ESR1 Antibodies), priming the middle cerebral artery territory for survival after experimental focal ischemia
The important role of Ang-1 in the activation of mast cells, and a potential therapeutic effect of Ang-1 on anaphylaxis diseases.
Zebra fish (Danio rerio) morphants showed that mild knock down of Ang-1 produces a small-brained phenotype that could be rescued with Ang-1 mRNA.
Angiopoietin-1 receptor Tie2 (show TEK Antibodies) distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.
inhibition of NO production by Ang-1, via phosphorylation of eNOS (show NOS3 Antibodies) on Thr (show TRH Antibodies)(497) by PKC zeta (show PRKCZ Antibodies), is responsible, at least in part, for inhibition of VEGF (show VEGFA Antibodies)-stimulated endothelial permeability by Ang-1.
Angiopoietin 1 was predominantly present in the maturing glomeruli.
The expression of ANGPT1 has already been studied during metanephric glomerulogenesis, but it remains to be elucidated during the development of the embryonic mesonephros.
Attenuates H2O2-induced stress-activated protein kinase (show CDK7 Antibodies) (SEK)1 (show MAP2K4 Antibodies)/JNK (show MAPK8 Antibodies) phosphorylation through the PI 3 (show PI3 Antibodies)-kinase/Akt (show AKT1 Antibodies) pathway and inhibits the apoptosis of vascular endothelial cells induced by oxidative stress.
Estrogen-dependent control of Ang-1 expression plays an important role in stabilizing meningeal microvessel and maintaining healthy microvascular networks.
forward mandibular positioning enhance the expression of Ang1 and Ang2 (show ANGPT2 Antibodies) in condylar cartilage.
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
, angiopoietin 1