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Human Angiopoietin 1 Protein expressed in Escherichia coli (E. coli) - ABIN667576
Kopczyńska, Makarewicz, Biedka, Kaczmarczyk, Kardymowicz, Tyrakowski: Plasma concentration of angiopoietin-1, angiopoietin-2 and Tie-2 in cervical cancer. in European journal of gynaecological oncology 2010
Show all 2 references for ABIN667576
Zebra fish (Danio rerio) morphants showed that mild knock down of Ang-1 produces a small-brained phenotype that could be rescued with Ang-1 mRNA.
Hydroxysafflor yellow A promotes angiogenesis in ischemic hindlimb via the angiopoietin 1/ (show TEK Proteins) Tie-2 signaling pathway.
COMP (show COMP Proteins)-Ang1 can enhance BMP2 (show BMP2 Proteins)-induced cranial bone regeneration with increased pericyte recruitment. Combined delivery of the proteins might be a therapeutic strategy to repair cranial bone damage.
Hematopoietic stem cells regulate the regeneration of their niche by secreting Angpt1.
Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.
Ang-1 strongly enhances skeletal muscle regeneration in response to fiber injury and that this effect is mediated through induction of the myogenesis program in muscle progenitor cells and the angiogenesis program in endothelial cells.
These results suggest that PRP extract prevents endotoxin-induced pulmonary edema mainly through Ang (show ANG Proteins)-Tie2 (show TEK Proteins) signaling, and PRP extract could be a potential therapeutic strategy for sepsis-induced pulmonary edema
E2 increases Ang-1 and enhances capillary density in brain under basal conditions through estrogen receptor-alpha (show ESR1 Proteins), priming the middle cerebral artery territory for survival after experimental focal ischemia
The important role of Ang-1 in the activation of mast cells, and a potential therapeutic effect of Ang-1 on anaphylaxis diseases.
findings report that Ang-1 induces arteriolar vasodilation via release of NO, suggesting that Ang-1 is an important regulator of microvascular tone.
Sonic hedgehog secreted by neurons regulates ang-1 and ang-2 expression in neighboring fibroblasts.
Ang-1 is not a predictive and clinically relevant biomarker in pulmonary hypertension
We could therefore conclude that angiogenesis is an important event in the development of common skin warts, and the upregulation of both Ang1 and -2 and their binding receptor Tie2 (show TEK Proteins) may play a role in the angiogenesis associated with the development of these lesions.
In vitro binding assays with purified components reveal that Tie-integrin recognition is direct, and further demonstrate that the receptor binding domain of the Tie2 ligand (show ANGPT2 Proteins) Ang-1, but not the receptor binding domain of Ang-2 (show ANGPT2 Proteins), can independently associate with a5b1 or aVb3. cooperative Tie/integrin interactions selectively stimulate ERK/MAPK (show MAPK1 Proteins) signaling in the presence of both Ang-1 and fibronectin (show FN1 Proteins)
Results uncovered ZO-1 (show TJP1 Proteins) as part of a signaling node activated by VEGF (show VEGFA Proteins), but not Ang-1, that specifically modulates endothelial cells proliferation during angiogenesis.
there was no immunohistochemical evidence for apoptosis or autophagy. Quantitative staining showed similar expression levels of the angiogenesis regulators VEGF-A (show VEGFA Proteins), VEGF-receptor 2 and Angpt1 (p = 0.11), but Angpt2 (show ANGPT2 Proteins) was significantly lower in CKD children (p = 0.01).
Ang-1 and -2 levels and the Ang-2 (show ANGPT2 Proteins)/Ang-1 ratio may be promising indicators of disease activity in hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli.
l-thyroxine increased Ang1 expression and induces bone formation, differentiation, and mineralization in U2OS and MG63 cell lines.
Hydroxysafflor yellow A promotes angiogenesis in HUVEC cells via the angiopoietin 1/ Tie-2 (show TEK Proteins) signaling pathway.
We conclude that aging shifts the balance of the Ang1/Ang2 network favouring a quiescent state. Activation of endothelial cells in aging might be necessary to enhance wound healing capacities.
Plasma Ang-1 levels were diminished in Behcet's disease patients, especially in patients with vascular involvement.
Angiopoietin 1 was predominantly present in the maturing glomeruli.
The expression of ANGPT1 has already been studied during metanephric glomerulogenesis, but it remains to be elucidated during the development of the embryonic mesonephros.
Attenuates H2O2-induced stress-activated protein kinase (show CDK7 Proteins) (SEK)1 (show MAP2K4 Proteins)/JNK (show MAPK8 Proteins) phosphorylation through the PI 3 (show PI3 Proteins)-kinase/Akt (show AKT1 Proteins) pathway and inhibits the apoptosis of vascular endothelial cells induced by oxidative stress.
Estrogen-dependent control of Ang-1 expression plays an important role in stabilizing meningeal microvessel and maintaining healthy microvascular networks.
Angiopoietin-1 receptor Tie2 (show TEK Proteins) distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.
inhibition of NO production by Ang-1, via phosphorylation of eNOS (show NOS3 Proteins) on Thr (show TRH Proteins)(497) by PKC zeta (show PRKCZ Proteins), is responsible, at least in part, for inhibition of VEGF (show VEGFA Proteins)-stimulated endothelial permeability by Ang-1.
Involved in the conversion of lanosterol to cholesterol.
, angiopoietin 1
, C-14 sterol reductase
, another new gene 1 protein
, delta(14)-sterol reductase
, putative sterol reductase SR-1
, sterol C14-reductase