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These data suggest that certain DCE-MRI parameters correlate with R-ISS and adverse prognostic features of angiogenesis, such as the ratio of Angp-1/Angp-2.
study revealed decreased levels of VEGF (show VEGFA Proteins), ANGPT1, and MMP-9 (show MMP9 Proteins) in the early post-transplant period as compared to the baseline (BC). ANGPT2 (show ANGPT2 Proteins) was decreased after conditioning treatment, but tended to increase from day +7. On day +7, positive correlations between ANGPT1 level as well as MMP-9 (show MMP9 Proteins) and the time to engraftment were observed.
These results indicate that the Angpt-Tie2 (show TEK Proteins) system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 (show TEK Proteins) agonists could be a therapeutic option for glaucoma.
Ang-1 specifically increases circulating Gr1(+ )inflammatory monocytes and increases monocyte/macrophage retention in atherosclerotic plaques, thereby contributing to development of atherosclerosis.
NOX2 (show CYBB Proteins), NOX4 (show NOX4 Proteins), and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 signaling and angiogenic responses in endothelial cells.
ANG-1, ANG-2 (show ANGPT2 Proteins) and TIE-2 (show TEK Proteins) levels were significantly increased in placenta of non-complicated ART pregnancies compared to placentas from spontaneous conception.
study is the first one to report Ang1 capacity to induce MIP-1beta (show CCL4 Proteins) gene expression, protein synthesis and release from neutrophils, and that these effects are mediated by PI3K (show PIK3CA Proteins), p38 MAPK (show MAPK14 Proteins) and MEK (show MAP2K1 Proteins) activation and downstream NF-kappaB (show NFKB1 Proteins) activation
In this study, we found that angiopoietins and Tie receptors were highly expressed in cervical cancer cells. Tie-2 expression in tumor cells predicted poorer prognosis.Our data support that dual inhibition of Ang-1 and Ang-2 may be an alternative target for anti-angiogenic adjuvant therapy in advanced or recurrent cervical squamous cell cancer.
Data show that fibulin-5 (show FBLN5 Proteins) strongly binds to the endothelial cell surface reducing endothelial cell viability and interfering with the signaling pathways of the Ang-1/TIE-2 (show TEK Proteins) receptor axis.
Ang-1 is not a predictive and clinically relevant biomarker in pulmonary hypertension
These data define a role for dysregulation of the Ang (show ANG Proteins)-Tie-2 (show TEK Proteins) axis in the pathogenesis of cerebral malaria.
we demonstrate that targeted Ang-1 overexpression attenuates myofibroblast activation and interstitial collagen I accumulation, inhibits the upregulation of transforming growth factor beta1 and subsequent phosphorylation of Smad 2 (show SMAD2 Proteins)/3, dampens renal inflammation, and stimulates the growth of peritubular capillaries in the obstructed kidney.
Hydroxysafflor yellow A promotes angiogenesis in ischemic hindlimb via the angiopoietin 1/ Tie-2 (show TEK Proteins) signaling pathway.
COMP (show COMP Proteins)-Ang1 can enhance BMP2 (show BMP2 Proteins)-induced cranial bone regeneration with increased pericyte recruitment. Combined delivery of the proteins might be a therapeutic strategy to repair cranial bone damage.
Hematopoietic stem cells regulate the regeneration of their niche by secreting Angpt1.
Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.
Ang-1 strongly enhances skeletal muscle regeneration in response to fiber injury and that this effect is mediated through induction of the myogenesis program in muscle progenitor cells and the angiogenesis program in endothelial cells.
These results suggest that PRP extract prevents endotoxin-induced pulmonary edema mainly through Ang (show ANG Proteins)-Tie2 (show TEK Proteins) signaling, and PRP extract could be a potential therapeutic strategy for sepsis-induced pulmonary edema
E2 increases Ang-1 and enhances capillary density in brain under basal conditions through estrogen receptor-alpha (show ESR1 Proteins), priming the middle cerebral artery territory for survival after experimental focal ischemia
Zebra fish (Danio rerio) morphants showed that mild knock down of Ang-1 produces a small-brained phenotype that could be rescued with Ang-1 mRNA.
Angiopoietin-1 receptor Tie2 (show TEK Proteins) distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.
inhibition of NO production by Ang-1, via phosphorylation of eNOS (show NOS3 Proteins) on Thr (show TRH Proteins)(497) by PKC zeta (show PRKCZ Proteins), is responsible, at least in part, for inhibition of VEGF (show VEGFA Proteins)-stimulated endothelial permeability by Ang-1.
Angiopoietin 1 was predominantly present in the maturing glomeruli.
The expression of ANGPT1 has already been studied during metanephric glomerulogenesis, but it remains to be elucidated during the development of the embryonic mesonephros.
Attenuates H2O2-induced stress-activated protein kinase (show CDK7 Proteins) (SEK)1 (show MAP2K4 Proteins)/JNK (show MAPK8 Proteins) phosphorylation through the PI 3 (show PI3 Proteins)-kinase/Akt (show AKT1 Proteins) pathway and inhibits the apoptosis of vascular endothelial cells induced by oxidative stress.
Estrogen-dependent control of Ang-1 expression plays an important role in stabilizing meningeal microvessel and maintaining healthy microvascular networks.
forward mandibular positioning enhance the expression of Ang1 and Ang2 in condylar cartilage.
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
, angiopoietin 1