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Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers
Therefore, the idea was conceived that the overexpression of EphA10 in prostate cancers might have a potential as a target for prostate cancer therapy, and formed the basis for the studies reported here.
EphA10 expression at both the gene and protein level in clinical breast cancer tissues is significantly associated with lymph node metastasis as well as stage progression.
EPHA10 does not interact with EPHB6 (show EPHB6 Proteins) in breast neoplasms
CLL B-cells showed a more heterogeneous Eph (show EPHA1 Proteins)/EFN profile, specially EFNA4 (show EFNA4 Proteins), EphB6 (show EPHB6 Proteins) and EphA10.
Ephrin A10 is significantly increased in hippocampus following epileptogenesis.
Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005
, ephrin type-A receptor 10