EPH Receptor A10 Protein (EPHA10) (AA 34-565) (His tag)

Catalog No. ABIN7274548

This Recombinant EPH Receptor A10 protein is expressed in HEK-293 Cells.

Quick Overview for EPH Receptor A10 Protein (EPHA10) (AA 34-565) (His tag) (ABIN7274548)

Target: EPH Receptor A10 (EPHA10)

Protein Type: Recombinant

Biological Activity: Active

Origin: Cynomolgus

Source: HEK-293 Cells

Purity: > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC

Product Details

Protein Characteristics: AA 34-565

Purification tag / Conjugate: This EPH Receptor A10 protein is labelled with His tag.

Purpose: Cynomolgus EPHA10 Protein

Sequence: Glu34-Ala565

Characteristics: Recombinant Cynomolgus EPHA10 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu34-Ala565.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1 EU per μg by the LAL method.

Biological Activity Comment: Cynomolgus EPHA10 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,The purity of Cynomolgus EPHA10 is greater than 95% as determined by SEC-HPLC.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1 mg/mL for 500 μg or 1 mg lyophilized powder. Do not mix by vortex or vigorous shaking.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3 months after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: EPH Receptor A10 (EPHA10)

Alternative Name: EPHA10

Background: EphA10 (erythropoietin-producing hepatocellular carcinoma receptor A10) is a catalytically defective receptor protein tyrosine kinase in the ephrin receptor family.EphA10 was elevated and higher in tumor tissues than in normal tissues in some cancer types, including pancreatic cancer.EphA10 silencing reduced the proliferation, migration, and adhesion of MIA PaCa-2 and AsPC-1 pancreatic cancer cells. EphA10 plays a pivotal role in the tumorigenesis of pancreatic epithelial cells and is a novel therapeutic target for pancreatic cancer.

Molecular Weight: 58.56 kDa. Due to glycosylation, the protein migrates to 68-78 kDa based on Bis-Tris PAGE result.

NCBI Accession: XP_045230088

Pathways: RTK Signaling