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Fgf3 (show FGF3 Proteins) and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish.
Fgf10 and Fgf3 (show FGF3 Proteins) secreted from the forming neurohypophysis exert direct guidance effects on hypothalamic neurosecretory axons.
through the analysis of fgf10(-/-); fgf24(-/-) embryos, the specific role of these two FGF ligands in the induction of the ventral pancreas and in the repression of the hepatic fate was revealed.
fgf10a, which is expressed in the mesenchyme surrounding non-hepatic endodermal cells, negatively impacts the regulative capacity of endodermal tissues.
Functional investigation of a subset of these genes, fgf10a, tgfb2 (show TGFB2 Proteins), pax9 (show PAX9 Proteins), and smad5 (show SMAD5 Proteins) revealed their necessity in zebrafish palatogenesis.
Data show that the Ihha-Fgf10 regulatory interaction is realized through a signaling feedback loop between the Ihha-expressing epithelium and Fgf10-expressing mesenchyme.
These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence.
Positional cloning identifies fgf10 as the gene disrupted in daedalus.
Fgf10 signaling from the adjacent mesenchyme is responsible for refining the boundaries
Fgf10 acts redundantly with Fgf24 in the pancreatic lateral plate mesoderm and they are both required to specify the ventral pancreas.
The present data indicate that non-natural FGFR2 (show FGFR2 Proteins) ligands, such as FGF10 and FGF19 (show FGF19 Proteins), are important factors in the pathophysiology of Aspert syndrome.
data suggest that the strongest signal of association at 5p12 is mediated through coordinated activation of FGF10 and MRPS30 (show MRPS30 Proteins), two candidate genes for breast cancer pathogenesis
Fgf10 signaling has an essential role in the formation of lipofibroblasts during late lung development
Expression of Fibroblast Growth Factor 10 is correlated with poor prognosis in gastric adenocarcinoma.
FGF10 has a role in protecting neuron against oxygen-glucose deprivation injury through inducing heme oxygenase-1 (show HMOX1 Proteins)
Data identify autocrine activation of FGF signaling as an essential mechanism in promoting Pten-deficient skin tumors.
precursor of the hormone Irisin (show FNDC5 Proteins) (FNCD5) were abundantly expressed in all three fat depots, along with fibroblast growth factors (FGF) FGF1 (show FGF1 Proteins), FGF7 (show FGF7 Proteins) and FGF10, whereas, FGF19 (show FGF19 Proteins) and FGF21 (show FGF21 Proteins) were undetectable.
The therapeutic potential of the FGF10 treatment.
FGF10 plays an important role for tumor growth by both paracrine and autocrine manner.
The findings show that immunohistochemistry with FGF10, FGFR2b, or SHH (show SHH Proteins) could be useful in differentiating CCAM (show CEACAM1 Proteins) from type I PPB (show HTN1 Proteins), when a child presents with a focal cystic lung lesion.
reactivating SHH (show SHH Proteins) signaling in mutant lungs rescued the tip dilation phenotype and attenuated FGF signaling. Importantly, the reduced SHH (show SHH Proteins) signaling activity did not appear to be caused by decreased Shh (show SHH Proteins) expression or protein stability; instead, biologically active form of SHH (show SHH Proteins) proteins were reduced in both the Ext1 (show EXT1 Proteins) mutant epithelium and surrounding wild type mesenchymal cells.
that miR (show MLXIP Proteins)-205 in the surface ectoderm functions to ensure robust activation of pathways associated with Fgf10 signaling.
Mesenchymal FGF10 controls the size of the taste bud papillary area, while overall patterning remains unchanged. Results show that FGF signaling negatively affects the extent of canonical Wnt (show WNT2 Proteins) signaling, which is the main activation pathway during fungiform papillae development; however, this effect does not occur at the level of gene transcription.
Sox9 (show SOX9 Proteins) is positively regulated by mesenchymal Fgf10, a process that requires active Erk (show EPHB2 Proteins) signaling during salivary gland development
Fgf10 is expressed in the mesenchyme around developing submucosal glands. All nasal glands require FGF10 for branching morphogenesis. FGF10 is required for gland budding and ductal morphogenesis of the Steno's gland and the maxillary sinus glands.
FGFR2c signaling regulates branching morphogenesis through the activation of FGFR2b signaling via increased FGF10 autocrine. These results provide new insight into the mechanisms by which crosstalk between FGFR2b and FGFR2c results in efficient branching morphogenesis.
Decreased Fgf10 mRNA levels lead to congenital lung defects, which are compatible with postnatal survival, but which compromise the ability of the lungs to cope with sub-lethal hyperoxic injury.
Fgf10 enhances the formation of tissue-engineered small intestine.
Lhx9 (show LHX9 Proteins) expression overlapped markedly with FGF10 expression cells in the limb mesenchyme and was associated with proliferative cells of the progress zone.
Hypoplasia of the salivary glands led to a significant reduction in saliva (show RAG1AP1 Proteins) production in Fgf10 heterozygous adult mice
We found no difference between treatments regarding embryo production, developmental speed, and gene expression. CONCLUSION: In conclusion, the presence of FGF10 during IVM had no effect on embryo production, developmental speed, and gene expression.
The present data suggest a role for FGF10 in the control of fetal folliculogenesis in cattle.
BMP15 (show BMP15 Proteins) and FGF10 stimulate expansion of in cumulus-oocyte complexes by driving glucose metabolism toward hyaluronic acid production and controlling gene expression in the ovulatory cascade.
FGF10 and its receptor FGFR2b are more expressed in subordinate follicles; FGF10 acts as an important regulator of follicular growth in cattle.
These data support a role for FGF10 and fibroblast growth factor receptor 2B in signaling to granulosa cells from theca cells and/or the oocyte.(fibroblast growth factor receptor 2B)
FGF10 mRNA expression did not change during functional luteolysis, whereas FGFR2B mRNA abundance decreased significantly at 2, 4, and 12 hr after PGF2alpha, and returned to pretreatment levels for the period 24-64 hr post-PGF2alpha
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing.
, fibroblast growth factor 10
, keratinocyte growth factor 2
, produced by fibroblasts of urinary bladder lamina propria
, obg-like ATPase 1